Front Endocrinol (Lausanne) October 2022 PMID 36187122

Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials.

Katarzyna Nabrdalik, Karolina Skonieczna-Żydecka, Krzysztof Irlik, Mirela Hendel, Hanna Kwiendacz, Igor Łoniewski, Kornelia Januszkiewicz, Janusz Gumprecht, Gregory Y H Lip

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Mentions

12
Peak: 3 in Sep 2022
across 3 sources since Sep 2022

Extended reach

263,010
potential audience

Total likes

5,700

Video views

249,536

Mentions per month

Sep 2022 – Mar 2025

Where it's discussed

  • X / Twitter6 posts
  • News4 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect recognition of the article's findings on gastrointestinal side effects, with several posts sharing personal experiences or questioning the broader implications, using tone and language that suggest genuine concern and curiosity. For example, one participant mentions that metformin causes diarrhea in 20-30% of patients, demonstrating direct engagement with the subject, while others question its use in treating Long Covid, indicating its impact on ongoing debates.

AgreementModerate agreement

Most discussions acknowledge and support the findings of the publication, citing known side effects like gastrointestinal issues caused by metformin.

InterestModerate interest

Participants show moderate curiosity, with some expressing surprise or skepticism about claims, indicating a sustained but cautious interest.

EngagementModerate engagement

Comments include personal experiences, references to specific side effects, and discussion of the research methodology, showing active involvement.

ImpactModerate impact

The discussions highlight practical implications for treatment and skepticism, indicating the article's influence on perceptions and debates about diabetes management.

Top posts

Most liked on X and Bluesky
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials: Introduction Metformin is the… https://t.co/OzOt4zbCXQ #Endocrinology #Endo

Sep 14, 2022 · 2 likes · 1 share · 5,052 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

"Frontiers | Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials" @LHCH @LivHPartners @LJMU_Health : https://t.co/zXZ1kal9Q9 https://t.co/CzkhtiO4OF

Sep 14, 2022 · 1 like · 1,475 followers View post →
LongestHaul
@LongestHaul · X

@jamesrx1 @roxy_mojo Well I know for a fact it causes diarrhea and GI issues in 20-30% of patients. It is insane to me people are claiming it is a Long Covid Treatment. https://t.co/ieArB8Unw0

Feb 7, 2024 · 1 like · 163 followers View post →
TOMO@北の薬屋®
@kitanokusuriya · X

@nankooochan 追加で見ていても、今は 用量依存的に有害事象が増えるは否定的なものが多い気がしました。 これも、2500mg/dでは消化器系の有害事象が多かったけど、それ以下では変わりない。 1. https://t.co/4cXyiCK176 その他2つも同様 2. https://t.co/Zaf1TGntym 3. https://t.co/IfrfB9bWPt

Mar 7, 2025 · 4,724 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies https://t.co/gUfb8Q8JhV https://t.co/qEJpeXYJbN

Oct 25, 2024 · 1,475 followers View post →
Cordoba Lab (Liver Lab)_UIC Diabetes Center
@Cordoba_Lab · X

RT @FrontEndocrinol: New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A syst…

Sep 14, 2022 · 1 share · 582 followers View post →

All mentions

TOMO@北の薬屋®
@kitanokusuriya · X

@nankooochan 追加で見ていても、今は 用量依存的に有害事象が増えるは否定的なものが多い気がしました。 これも、2500mg/dでは消化器系の有害事象が多かったけど、それ以下では変わりない。 1. https://t.co/4cXyiCK176 その他2つも同様 2. https://t.co/Zaf1TGntym 3. https://t.co/IfrfB9bWPt

Mar 7, 2025 · 4,724 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis with meta-regression of observational studies https://t.co/gUfb8Q8JhV https://t.co/qEJpeXYJbN

Oct 25, 2024 · 1,475 followers View post →
LongestHaul
@LongestHaul · X

@jamesrx1 @roxy_mojo Well I know for a fact it causes diarrhea and GI issues in 20-30% of patients. It is insane to me people are claiming it is a Long Covid Treatment. https://t.co/ieArB8Unw0

Feb 7, 2024 · 1 like · 163 followers View post →
Cordoba Lab (Liver Lab)_UIC Diabetes Center
@Cordoba_Lab · X

RT @FrontEndocrinol: New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A syst…

Sep 14, 2022 · 1 share · 582 followers View post →
Frontiers - Endocrinology
@FrontEndocrinol · X

New Research: Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials: Introduction Metformin is the… https://t.co/OzOt4zbCXQ #Endocrinology #Endo

Sep 14, 2022 · 2 likes · 1 share · 5,052 followers View post →
Liverpool Centre for Cardiovascular Science
@LiverpoolCCS · X

"Frontiers | Gastrointestinal adverse events of metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials" @LHCH @LivHPartners @LJMU_Health : https://t.co/zXZ1kal9Q9 https://t.co/CzkhtiO4OF

Sep 14, 2022 · 1 like · 1,475 followers View post →