FEBS Lett February 2023 PMID 36203246

Abiogenesis through gradual evolution of autocatalysis into template-based replication.

Polina Pavlinova, Camille N Lambert, Christophe Malaterre, Philippe Nghe

Mentions

39
Peak: 7 in Aug 2024
across 4 sources since Oct 2022

Extended reach

64,726
potential audience

Total likes

58

Video views

122

Mentions per month

Oct 2022 – Oct 2025

Where it's discussed

  • X / Twitter31 posts
  • Facebook4 posts
  • News3 articles
  • YouTube1 videos

AI synopsis

What people are saying

Overall, the discussion reflects a skeptical tone, with several posts challenging the scientific validity of the publication by calling it 'theoretic' and highlighting the lack of concrete examples, such as in 'everything is theoretical with no plausible examples of early earth abiogenesis.' The tone ranges from dismissive to mildly engaged, as seen in comments questioning the science and references to biological concepts, but with limited depth or consensus on the significance.

AgreementLow agreement

Most discussions question the scientific validity or practical relevance of the publication, indicating a tendency towards disagreement.

InterestNeutral interest

The range of responses suggests mixed or moderate interest, with some engagement but also skepticism or indifference.

EngagementModerate engagement

While some comments actively critique or analyze concepts, others dismiss or dismissively reference the work without deep discussion.

ImpactLow impact

The discussions seem to have limited influence on broader scientific or philosophical debates, often focusing on skepticism or trivial criticisms.

Abstract in brief

  • The article explores how life might have originated from non-living matter through the gradual evolution of chemical systems, focusing on RNA's role in this process under the RNA world hypothesis, which suggests RNA molecules existed before DNA and proteins.
  • It highlights the importance of identifying ribozymes that can self-replicate, a key step for RNA-based evolution, but notes that such a self-replicating ribozyme has not yet been discovered; instead, scientists are investigating autocatalytic RNA systems that involve multiple RNA molecules.
  • The article proposes a gradual pathway where simple autocatalytic RNA systems evolve over time into more complex replication mechanisms, enabling properties like variation, heredity, and reproduction essential for Darwinian evolution to emerge.]

Top posts

Most liked on X and Bluesky
LeRaptorSauvage
@RaptorSauvage · X

la Biochimie avec le modèle de l’Abiogenèse. Voir ceci : -https://t.co/ikpjIzTQ97 -https://t.co/TmFDfOi7Rk -https://t.co/ufSOUlnoG6 Au passage, on est capable de créer des organismes synthétique comme des levures eucaryotes. (https://t.co/1zEUQty3jA)

Aug 6, 2024 · 22 likes · 4 shares · 1,335 followers View post →
jojo ton cauchemar
@manisanmonkey · X

D'ailleurs pour les curieux sur le sujet : https://t.co/m68anvVZy1 Bientôt il va nous dire que l'on a des preuves géologiques du déluge et que l'on a retrouvé l'arche de Noé

Aug 6, 2024 · 10 likes · 1 share · 117 followers View post →
Astrobiology
@astrobiology · X

Abiogenesis through gradual evolution of autocatalysis into template-based replication https://t.co/YobDbj9PDz #astrobiology

Oct 10, 2022 · 3 likes · 2 shares · 35,777 followers View post →
Tezcatlipoca
@1Quetzalcoatl1 · X

@SavedByGrace300 @HarryNockz @AiG Falsely passed off as science? So scientific papers aren't actual science? https://t.co/7WaswTCuiO

Sep 27, 2025 · 2 likes · 2,917 followers View post →
CIRST
@leCIRST · X

Publication | Abiogenesis through gradual evolution of autocatalysis into template-based replication... Quand la philosophie

Mar 6, 2023 · 2 likes · 1 share · 1,775 followers View post →
Eddie Tellez
@Mesocortical · X

@WardenCringe @FrankGr67034658 @Lilith_Atheist This is embarrassing for you: https://t.co/F0whKaZOvb https://t.co/sPDhpfKqj2 https://t.co/SQeZ0ewPgq Still no rebuttal besides nuh uh?

Jan 2, 2025 · 2 likes · 78 followers View post →

All mentions

Whale-Oil-Beef-Hooked
@steiner289 · X

@DorsetCouple @Thedon9994 @AiG https://t.co/XLQCIw6r8G https://t.co/t6zMjHkG6t https://t.co/rhl3IyFFsx https://t.co/D21meufjBx The problem is that you need cell parts to replicate RNA, but you can't make cell parts without a cell. It's a circular problem.

Oct 17, 2025 · 14 followers View post →
Tezcatlipoca
@1Quetzalcoatl1 · X

@SavedByGrace300 @HarryNockz @AiG Falsely passed off as science? So scientific papers aren't actual science? https://t.co/7WaswTCuiO

Sep 27, 2025 · 2 likes · 2,917 followers View post →
Sevthecruel
@SevAkbal · X

@elordendelser @Jeremy_Antuam @elsiervo__ https://t.co/2EKdxBgkzC Spontaneous network formation among cooperative RNA replicators: https://t.co/t6dcpl3oHu.. esting ideas in prebiotic analogue conditions: https://t.co/dZpdpjh26J Self-sustained replication of an RNA enzyme: https://t.co/BJeqR3vPIQ.. "Lo siento"

Aug 27, 2025 · 119 followers View post →
Eddie Tellez
@Mesocortical · X

@JWS846893322695 @iamAtheistGirl Here's a review paper that discusses various mechanisms by which self-replicating RNA molecules can engage in chemical evolution, which can lead to the emergence of novel functions - https://t.co/HGM1T15XjU

Apr 1, 2025 · 78 followers View post →
♘ᴅᴀʀᴋ∜Ω
@Ve2ge · X

@lele14441 https://t.co/VynLwmsnGR

Feb 3, 2025 · 1 like · 640 followers View post →
A- void
@Avoid1691987 · X

@REPENTAVOIDHELL @butthisisshort @Lilith_Atheist as a matter of fact... https://t.co/jBDpdVhrEB it is apparently well understood matter. https://t.co/7zF74bToSo https://t.co/G3Nh63gRog https://t.co/qBZqqO3VDN https://t.co/qIVhyIZKbg that enough proof? 3 primary sources and 2 popscience magazines.

Jan 4, 2025 · 1 like · 169 followers View post →
Sidetracked
@SDAFS56788141 · X

@Mesocortical @WardenCringe @FrankGr67034658 @Lilith_Atheist Last, but least, it isn't even a research paper, but a review article. Everything is theoretical with no plausible examples of early earth abiogenesis. Trifecta of irrelevance. \ https://t.co/rsFgPzk5U8

Jan 2, 2025 · 515 followers View post →
Eddie Tellez
@Mesocortical · X

@WardenCringe @FrankGr67034658 @Lilith_Atheist This is embarrassing for you: https://t.co/F0whKaZOvb https://t.co/sPDhpfKqj2 https://t.co/SQeZ0ewPgq Still no rebuttal besides nuh uh?

Jan 2, 2025 · 2 likes · 78 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@blowave @picksixing @darwintojesus Short RNA strands form spontaneously and autocatalyse the formation of longer strings. https://t.co/U3RnxZNE5d

Oct 19, 2024 · 2,806 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@YaredScott @picksixing @darwintojesus But these would be extremophiles whose RNA DOES mutate at a high rate: Again, high mutation rates are necessary for RNA World to be feasible in the first place. https://t.co/U3RnxZNE5d

Oct 19, 2024 · 2,806 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@YaredScott @picksixing @darwintojesus But protocells aren't really alive in the first place. They're just phospholipid membranes containing short RNA strands which DO mutate and autocatalyse, in harsh conditions indeed. https://t.co/U3RnxZNE5d We don't know what features the true Last Universal Common Ancestor had,

Oct 19, 2024 · 2,806 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@hojadi @darwintojesus You believe a god of some gap lives in THIS gap you fucking cretin. https://t.co/2N0UWSgYGt

Oct 14, 2024 · 2,806 followers View post →
Daytime Pub Smell
@DaytimePubSmell · X

@SDAFS56788141 @darwintojesus It is the diagram of all the required steps. Almost all of the steps happen straightforwardly via the mechanisms in the bottom right. The remaining gaps might require some supernatural catalyst or other, but they're very odd Gaps for Gods. https://t.co/2N0UWSgYGt

Oct 13, 2024 · 2,806 followers View post →
Ævie (Comms Open)
@Automata_Eve · X

@REPENTAVOIDHELL https://t.co/z0sr1kBP5B

Sep 21, 2024 · 2 likes · 56 followers View post →
Adam
@Adamleclement · X

RT @LeRaptorWild: la Biochimie avec le modèle de l’Abiogenèse. Voir ceci : -https://t.co/ikpjIzTQ97 -https://t.co/TmFDfOi7Rk -https://t.co/…

Aug 8, 2024 · 4 shares · 559 followers View post →
Antarès
@Antars50408936 · X

RT @LeRaptorWild: la Biochimie avec le modèle de l’Abiogenèse. Voir ceci : -https://t.co/ikpjIzTQ97 -https://t.co/TmFDfOi7Rk -https://t.co/…

Aug 8, 2024 · 4 shares · 605 followers View post →
Adam
@Adamleclement · X

RT @allahkt1: D'ailleurs pour les curieux sur le sujet : https://t.co/m68anvVZy1 Bientôt il va nous dire que l'on a des preuves géologique…

Aug 7, 2024 · 1 share · 559 followers View post →
aymart jean
@aymartjean · X

RT @LeRaptorWild: la Biochimie avec le modèle de l’Abiogenèse. Voir ceci : -https://t.co/ikpjIzTQ97 -https://t.co/TmFDfOi7Rk -https://t.co/…

Aug 7, 2024 · 4 shares · 345 followers View post →
jaune d'œuf apostat 3
@apostatsapiens3 · X

RT @LeRaptorWild: la Biochimie avec le modèle de l’Abiogenèse. Voir ceci : -https://t.co/ikpjIzTQ97 -https://t.co/TmFDfOi7Rk -https://t.co/…

Aug 7, 2024 · 4 shares · 1,760 followers View post →
LeRaptorSauvage
@RaptorSauvage · X

la Biochimie avec le modèle de l’Abiogenèse. Voir ceci : -https://t.co/ikpjIzTQ97 -https://t.co/TmFDfOi7Rk -https://t.co/ufSOUlnoG6 Au passage, on est capable de créer des organismes synthétique comme des levures eucaryotes. (https://t.co/1zEUQty3jA)

Aug 6, 2024 · 22 likes · 4 shares · 1,335 followers View post →
jojo ton cauchemar
@manisanmonkey · X

D'ailleurs pour les curieux sur le sujet : https://t.co/m68anvVZy1 Bientôt il va nous dire que l'on a des preuves géologiques du déluge et que l'on a retrouvé l'arche de Noé

Aug 6, 2024 · 10 likes · 1 share · 117 followers View post →
Jesse Mazer
@Lasermazer · X

@MikaelKrauze That's what you said earlier but I also asked whether the sequence of nucleotides in a self-replicating strand of RNA is code, & if not which of the proposed steps in the paper at https://t.co/puZ6dSGiwt would qualify--absent a general def the notion of "code" seems fuzzy to me

Mar 21, 2024 · 150 followers View post →
Jesse Mazer
@Lasermazer · X

@MikaelKrauze There's a paper at https://t.co/puZ6dSGiwt with ideas about autocat. sets leading to RNA, and steps bt. simple self-replication and template-based replication (see figure 7)...speculative, but do you think a prior impossible since you can't naturally go from non-code to code?

Feb 6, 2024 · 150 followers View post →
Iron-Charioteer
@MDH_UAR · X

@ShaneRosengren @autocorrect2_0 https://t.co/EwLHlVhJdR

Aug 31, 2023 · 587 followers View post →
Denning
@nanonauto · X

@Disciple4Lif @KamalaHarris https://t.co/w8nX93Yx9g

Aug 21, 2023 · 706 followers View post →
Denning
@nanonauto · X

@Disciple4Lif @KamalaHarris https://t.co/w8nX93Yx9g

Aug 21, 2023 · 706 followers View post →
AmigaNuts - Baloney detection kit equipped!
@AmigaNuts · X

@ChrisLouw10 @KellyPearsall3 @DontMakeWaves @JohnPiper 12/34 … https://t.co/Pq4HIRlUSR Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World https://t.co/9TNOa5hTBN , …

Mar 17, 2023 · 351 followers View post →
AmigaNuts - Baloney detection kit equipped!
@AmigaNuts · X

@ChrisLouw10 @KellyPearsall3 @DontMakeWaves @JohnPiper 11/34 … "Where does the preponderance of evidence point?" question in support of the abiogenesis scientific hypothesis: Abiogenesis through gradual evolution of autocatalysis into template-based replication https://t.co/fV1Faev2hn , …

Mar 17, 2023 · 351 followers View post →
Rachel Kongo
@KongoRachel · X

RT @leCIRST: Publication | Abiogenesis through gradual evolution of autocatalysis into template-based replication... Quand la philosophie

Mar 7, 2023 · 1 share · 34 followers View post →
CIRST
@leCIRST · X

Publication | Abiogenesis through gradual evolution of autocatalysis into template-based replication... Quand la philosophie

Mar 6, 2023 · 2 likes · 1 share · 1,775 followers View post →
Astrobiology
@astrobiology · X

Abiogenesis through gradual evolution of autocatalysis into template-based replication https://t.co/YobDbj9PDz #astrobiology

Oct 10, 2022 · 3 likes · 2 shares · 35,777 followers View post →
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