Nat Med October 2022 PMID 36216945

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.

W Timothy Garvey, Rachel L Batterham, Meena Bhatta, Silvio Buscemi, Louise N Christensen, Juan P Frias, Esteban Jódar, Kristian Kandler, Georgia Rigas, Thomas A Wadden, Sean Wharton

Mentions

275
Peak: 47 in Oct 2022
across 6 sources since Oct 2022

Extended reach

948,681
potential audience

Total likes

1,095

Video views

76,254

Mentions per month

Oct 2022 – Oct 2025

Where it's discussed

  • News188 articles
  • X / Twitter65 posts
  • Blogs15 articles
  • Bluesky3 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Several discussions point out critical aspects of the STEP 5 trial, such as the average weight loss of 15.2% and the fact that the treatment isn't a 'cure.' Posts mention how while many achieved significant results, users caution about potential weight regain after treatment. Phrases like 'not a cure' and 'significant weight loss' reflect a serious tone, indicating that while there’s excitement about the treatment's potential, there's also a need for realistic expectations regarding its effectiveness.

AgreementModerate agreement

Many discussions express a positive sentiment toward the findings of the STEP 5 trial, indicating general support for the efficacy of semaglutide in weight loss treatment.

InterestHigh interest

The topic has generated notable curiosity, as participants seek to understand the implications of the research on obesity treatment.

EngagementModerate engagement

While many users reference their personal experiences, there is clear engagement with the scientific details discussed, such as weight loss percentages and side effects.

ImpactHigh impact

The publication is perceived to have a significant influence on the obesity treatment landscape, with references to the importance of sustainability in weight loss results.

Abstract in brief

  • The STEP 5 trial evaluated the effectiveness and safety of a weekly injection of semaglutide 2.4 mg compared to a placebo for treating obesity in adults without diabetes, focusing on long-term results.
  • Participants in the semaglutide group lost an average of 15.2% of their body weight over 104 weeks, significantly more than the 2.6% weight loss in the placebo group, with 77.1% of the semaglutide group achieving a ≥5% weight loss compared to 34.4% in the placebo group.
  • While the treatment resulted in significant weight loss, gastrointestinal side effects were more common in the semaglutide group (82

Top posts

Most liked on X and Bluesky
Cristobal Morales
@CristobMorales · X

https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean change in body weight from baseline to week 104 was −15.2%” @SociedadSeedo @EASOobesity @sociedadSEEN @NovoNordiskES https://t.co/JtWtaqSC33

Oct 10, 2022 · 46 likes · 27 shares · 17,083 followers View post →
sean wharton
@seanwharton · X

We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. We have to strive for this. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/e4jqp9xiFS

Oct 11, 2022 · 24 likes · 3 shares · 2,857 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @NatureMedicine

Oct 10, 2022 · 22 likes · 8 shares · 35,519 followers View post →
Neil Floch MD
@NeilFlochMD · X

Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to week 104 was −15.2% in the semaglutide group (n = 152) versus −2.6% with placebo (n = 152), treatment difference of −12.6 % https://t.co/eI0m2zvP8m

Oct 11, 2022 · 13 likes · 4 shares · 130,123 followers View post →
Neil Floch MD
@NeilFlochMD · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m2zMSam

Nov 27, 2022 · 11 likes · 3 shares · 130,123 followers View post →
Barry Deutsch
@barrydeutsch.bsky.social · Bluesky

On semaglutide, for example (the most popular GLP-1), people's weight loss peaks at about 18%, and then levels off. Someone who weighs (for example) 350 lbs, and then loses 18% of their weight, will weigh about 290 lbs. So it's weight loss, but not a "cure" for being fat. 2/2

Jan 26, 2025 · 4 likes View post →

All mentions

Does Ozempic Effectively Aid Weight Loss?

Are you considering using Ozempic for weight loss? This video explores its effects, including significant weight loss observed in long-term studies. We discuss concerns about rebound weight gain after discontinuation…

Infarmate · Feb 15, 2023 75,585 views
Web diva Diná Toledo de A Viagem
@leianesonfire.bsky.social · Bluesky

Eu acompanho alguns canais de divulgação científica e principalmente sobre alimentação e endocrinologia e eu gosto muito da Kamarada Luna, queria mais divulgadores abertamente de esquerda/marxistas youtu.be/egF6hPqPMjY?...

Oct 17, 2025 · 1 like · 1 share View post →
Barry Deutsch
@barrydeutsch.bsky.social · Bluesky

On semaglutide, for example (the most popular GLP-1), people's weight loss peaks at about 18%, and then levels off. Someone who weighs (for example) 350 lbs, and then loses 18% of their weight, will weigh about 290 lbs. So it's weight loss, but not a "cure" for being fat. 2/2

Jan 26, 2025 · 4 likes View post →
Barry Deutsch
@barrydeutsch.bsky.social · Bluesky

Where did I say ANYTHING about six pack abs? Or about studies showing weight regains while staying on these drugs? Btu since you ask, semaglutide trials have shown small weight gains beginning after the 16th month. Such as this study published in "Nature." www.nature.com/articles/s41...

Jan 26, 2025 · 1 share View post →
sharon_welch
@sharonwelchfin · X

@EricsElectrons @MakisMD @ABDanielleSmith My charts with data from CDC WONDER (https://t.co/WhygyP1CiX). A rise in deaths with cancer at the end of '20 (first shots), mid '21 (highest weekly shots), and EOY '21 (boosters). Also supported by studies showing mechanistic links to cancer, such as https://t.co/i45LkQCmfv https://t.co/N8tw5I171l

Dec 9, 2024 · 66 followers View post →
sharon_welch
@sharonwelchfin · X

@vbbernard @DrPatSoonShiong Almost but not quite. What started at the end of 2020 and reached maximum uptake mid 2021? Hint: it's corroborated by mechanistic link to cancer: https://t.co/A5o06n3prc Data from CDC WONDER, and is replicated in other highly vaccinated countries too. https://t.co/TumTJscmc7

Dec 7, 2024 · 66 followers View post →
sharon_welch
@sharonwelchfin · X

@Jikkyleaks This is a 2 year RCT which had 1 death in the semaglutide group and none in the placebo: https://t.co/A5o06n3prc They claimed the death wasn't due to the drug. I don't necessarily believe them, but there was significant weight loss and obesity itself is a killer long-term.

Dec 6, 2024 · 66 followers View post →
Victoire
@VictoireL_au · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/CpQ25ZlaB3

Nov 17, 2024 · 3 followers View post →
CUN Surgery
@cun_surgery · X

@doctorValenti @fjavesc Semaglutide STEP trials

Jul 27, 2024 · 1 like · 89 followers View post →
Lluís Ridao
@lluisridao · X

☢️¡OJO! ¿Sirve REALMENTE OZEMPIC para BAJAR DE PESO? https://t.co/8NQBMe6NH5

Jul 1, 2024 · 710 followers View post →
Josef Murad
@JosefMurad · X

Source: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial: https://t.co/7kAzCQTdOG: https://t.co/7kAzCQTdOG

Feb 2, 2024 · 58 followers View post →
Mr. Anderson
@RazorbackAtty · X

@RogerSeheult I read "Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial", truly for someone else & came away thinking... does this really say what numerous stories & even the authors say? I've lost about 100 lbs thru https://t.co/EQhpT3Jnvn

Oct 24, 2023 · 485 followers View post →
Repositorio ABACUS
@AbacusUE · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/2rHqrT1taa

Jun 1, 2023 · 266 followers View post →
Tellit Likeitis
@Tellit007 · X

@DrNadolsky @dutchyankee2 @MichaelAlbertMD Step 5 showing results closer to tirze? https://t.co/6UxStFLA6t

Apr 27, 2023 · 150 followers View post →
Ryan Radia
@RyanRadia · X

@JamesMMiller2 @GreenValley_Guy @MattZeitlin Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/EcoUIHSYkB https://t.co/cvCXlFiZk0

Feb 27, 2023 · 1 like · 21,389 followers View post →
Stephan J. Guyenet
@sguyenet · X

@Kindke @DanielJDrucker Sorry it didn't work for you. In the trial above, 25% of ppl lost <5% of body wt. This includes the 13% who discontinued though. Together implies that 87% of ppl find it sustainable, and of those, it causes clinically significant wt loss in ~6 out of 7. https://t.co/CjDM3yTQIt

Jan 20, 2023 · 3 likes · 48,905 followers View post →
Kim Eunho
@PeraVich · X

RT @NeilFlochMD: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m…

Dec 5, 2022 · 3 shares · 52 followers View post →
Matt L
@LL41622309 · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/XQMi1tqK4Q

Nov 30, 2022 · 27 followers View post →
N
@NCKAR1999 · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Nov 30, 2022 · 8 shares · 14 followers View post →
Christine Lovato MD
@DrCLovato · X

RT @NeilFlochMD: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m…

Nov 27, 2022 · 3 shares · 2,096 followers View post →
BruceWolffenbuttel
@bhrw · X

RT @NeilFlochMD: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m…

Nov 27, 2022 · 3 shares · 2,736 followers View post →
Neil Floch MD
@NeilFlochMD · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m2zMSam

Nov 27, 2022 · 11 likes · 3 shares · 130,123 followers View post →
UCL Discovery
@ucl_discovery · X

Open Access UCL Research: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial - UCL Discovery https://t.co/Z1apXe5wk1

Oct 19, 2022 · 2,521 followers View post →
Novo Nordisk US Medical
@novonordiskmed · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Oct 17, 2022 · 8 shares · 745 followers View post →
Tony Martín
@Tonymartincasti · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 12, 2022 · 27 shares · 353 followers View post →
Óscar Baro Pato
@baro_dr · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 12, 2022 · 27 shares · 924 followers View post →
Beatrizvoltas
@Beatrizvoltas1 · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 12, 2022 · 27 shares · 1,019 followers View post →
Semergen Extremadura
@SemergenEx · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 12, 2022 · 27 shares · 1,069 followers View post →
Neil Floch MD
@NeilFlochMD · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Oct 12, 2022 · 8 shares · 130,123 followers View post →
Zaher Toumi MD
@ZaherToumi · X

RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…

Oct 12, 2022 · 4 shares · 7,813 followers View post →
Glenn Loomis, MD
@GlennLoomisMD · X

RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…

Oct 12, 2022 · 4 shares · 650 followers View post →
Neil Floch MD
@NeilFlochMD · X

RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…

Oct 12, 2022 · 4 shares · 130,123 followers View post →
Jose Miguel Alvarez
@michcabodoc · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 119 followers View post →
Jessica Qualls
@jessicahqualls · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/xBboe8unTZ

Oct 11, 2022 · 7 followers View post →
Interasma
@Interasma · X

Top story: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/wWgnjOhRzL, see more https://t.co/W6TOkmO9Sl

Oct 11, 2022 · 1 like · 2,445 followers View post →
Dr Davenport
@DrCDav · X

RT @seanwharton: We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. W…

Oct 11, 2022 · 3 shares · 568 followers View post →
MedPage Endocrinology
@MedPageEndo · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 1,332 followers View post →
Roberto Gutiérrez
@DrRobertoGuti · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 784 followers View post →
Gaming Bot
@precisionmedbot · X

RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…

Oct 11, 2022 · 4 shares · 1,148 followers View post →
Neil Floch MD
@NeilFlochMD · X

Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to week 104 was −15.2% in the semaglutide group (n = 152) versus −2.6% with placebo (n = 152), treatment difference of −12.6 % https://t.co/eI0m2zvP8m

Oct 11, 2022 · 13 likes · 4 shares · 130,123 followers View post →
David Arterburn, MD, MPH
@davearterburn · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/bPnjzYrp32

Oct 11, 2022 · 3 likes · 2,233 followers View post →
Alimentación para la Salud
@alimsalud_mx · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 883 followers View post →
Neil Floch MD
@NeilFlochMD · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 130,123 followers View post →
LUIS GERARDO RODRIGUEZ TORRES
@LUISGER91044166 · X

RT @seanwharton: We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. W…

Oct 11, 2022 · 3 shares · 6 followers View post →
Juanmarcosgg
@juanmarcosgg · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 511 followers View post →
Alberto Dias Filho
@albertodiasf · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/BKYaGNlRBT

Oct 11, 2022 · 236 followers View post →
Juan Carlos Obaya
@jcobaya69 · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 11, 2022 · 27 shares · 858 followers View post →
sean wharton
@seanwharton · X

We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. We have to strive for this. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/e4jqp9xiFS

Oct 11, 2022 · 24 likes · 3 shares · 2,857 followers View post →
Daniela R
@DannyRiosM · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 517 followers View post →
Mauro
@Mauritobarce · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 591 followers View post →
名前
@akkiii0830 · X

Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine STEP5はnature medicineからか https://t.co/RA8KYhe0Xv

Oct 10, 2022 · 245 followers View post →
Manuel Codas, MD, FACP ®
@ManucoMd · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 2,843 followers View post →
Diego Bellido
@DiegoBellido2 · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 8,213 followers View post →
Esteban Jódar Gimeno
@estebanjodar · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Oct 10, 2022 · 8 shares · 4,520 followers View post →
Rene Garcia Macero
@Doc_renegarcia · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 272 followers View post →
Florentino Carral
@florencarral · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 1,043 followers View post →
Kennlly Cardoza
@kjossephcj · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 200 followers View post →
Andreea Ciudin
@AndreeaCiudin1 · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 1,048 followers View post →
BegoC
@BegoC · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 321 followers View post →
Chema Fernandez
@chemachir · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 3,837 followers View post →
The Heart
@ZHeart11768530 · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 32,796 followers View post →
Juan Ignacio Arano
@AranoIgnacio · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 92 followers View post →
Joel Bravo
@joelbravoes · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Oct 10, 2022 · 8 shares · 38 followers View post →
Ed Márquez
@dremarquezr · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 2,855 followers View post →
joana nicolau
@NicolauJoana · X

RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…

Oct 10, 2022 · 27 shares · 426 followers View post →
Cristobal Morales
@CristobMorales · X

https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean change in body weight from baseline to week 104 was −15.2%” @SociedadSeedo @EASOobesity @sociedadSEEN @NovoNordiskES https://t.co/JtWtaqSC33

Oct 10, 2022 · 46 likes · 27 shares · 17,083 followers View post →
Tony Hui
@realTonyHui · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Oct 10, 2022 · 8 shares · 1,291 followers View post →
Inamul Kabir
@kabir_inamul · X

RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…

Oct 10, 2022 · 8 shares · 185 followers View post →
Nature Reviews Endocrinology
@NatureRevEndo · X

Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @NatureMedicine

Oct 10, 2022 · 22 likes · 8 shares · 35,519 followers View post →