https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean change in body weight from baseline to week 104 was −15.2%” @SociedadSeedo @EASOobesity @sociedadSEEN @NovoNordiskES https://t.co/JtWtaqSC33
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.
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Oct 2022 – Oct 2025Where it's discussed
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What people are saying
Several discussions point out critical aspects of the STEP 5 trial, such as the average weight loss of 15.2% and the fact that the treatment isn't a 'cure.' Posts mention how while many achieved significant results, users caution about potential weight regain after treatment. Phrases like 'not a cure' and 'significant weight loss' reflect a serious tone, indicating that while there’s excitement about the treatment's potential, there's also a need for realistic expectations regarding its effectiveness.
Many discussions express a positive sentiment toward the findings of the STEP 5 trial, indicating general support for the efficacy of semaglutide in weight loss treatment.
The topic has generated notable curiosity, as participants seek to understand the implications of the research on obesity treatment.
While many users reference their personal experiences, there is clear engagement with the scientific details discussed, such as weight loss percentages and side effects.
The publication is perceived to have a significant influence on the obesity treatment landscape, with references to the importance of sustainability in weight loss results.
Abstract in brief
- The STEP 5 trial evaluated the effectiveness and safety of a weekly injection of semaglutide 2.4 mg compared to a placebo for treating obesity in adults without diabetes, focusing on long-term results.
- Participants in the semaglutide group lost an average of 15.2% of their body weight over 104 weeks, significantly more than the 2.6% weight loss in the placebo group, with 77.1% of the semaglutide group achieving a ≥5% weight loss compared to 34.4% in the placebo group.
- While the treatment resulted in significant weight loss, gastrointestinal side effects were more common in the semaglutide group (82
Top posts
Most liked on X and BlueskyWe just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. We have to strive for this. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/e4jqp9xiFS
Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @NatureMedicine
Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to week 104 was −15.2% in the semaglutide group (n = 152) versus −2.6% with placebo (n = 152), treatment difference of −12.6 % https://t.co/eI0m2zvP8m
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m2zMSam
On semaglutide, for example (the most popular GLP-1), people's weight loss peaks at about 18%, and then levels off. Someone who weighs (for example) 350 lbs, and then loses 18% of their weight, will weigh about 290 lbs. So it's weight loss, but not a "cure" for being fat. 2/2
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Eu acompanho alguns canais de divulgação científica e principalmente sobre alimentação e endocrinologia e eu gosto muito da Kamarada Luna, queria mais divulgadores abertamente de esquerda/marxistas youtu.be/egF6hPqPMjY?...
On semaglutide, for example (the most popular GLP-1), people's weight loss peaks at about 18%, and then levels off. Someone who weighs (for example) 350 lbs, and then loses 18% of their weight, will weigh about 290 lbs. So it's weight loss, but not a "cure" for being fat. 2/2
Where did I say ANYTHING about six pack abs? Or about studies showing weight regains while staying on these drugs? Btu since you ask, semaglutide trials have shown small weight gains beginning after the 16th month. Such as this study published in "Nature." www.nature.com/articles/s41...
@EricsElectrons @MakisMD @ABDanielleSmith My charts with data from CDC WONDER (https://t.co/WhygyP1CiX). A rise in deaths with cancer at the end of '20 (first shots), mid '21 (highest weekly shots), and EOY '21 (boosters). Also supported by studies showing mechanistic links to cancer, such as https://t.co/i45LkQCmfv https://t.co/N8tw5I171l
@vbbernard @DrPatSoonShiong Almost but not quite. What started at the end of 2020 and reached maximum uptake mid 2021? Hint: it's corroborated by mechanistic link to cancer: https://t.co/A5o06n3prc Data from CDC WONDER, and is replicated in other highly vaccinated countries too. https://t.co/TumTJscmc7
@Jikkyleaks This is a 2 year RCT which had 1 death in the semaglutide group and none in the placebo: https://t.co/A5o06n3prc They claimed the death wasn't due to the drug. I don't necessarily believe them, but there was significant weight loss and obesity itself is a killer long-term.
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/CpQ25ZlaB3
@doctorValenti @fjavesc Semaglutide STEP trials
☢️¡OJO! ¿Sirve REALMENTE OZEMPIC para BAJAR DE PESO? https://t.co/8NQBMe6NH5
Source: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial: https://t.co/7kAzCQTdOG: https://t.co/7kAzCQTdOG
@RogerSeheult I read "Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial", truly for someone else & came away thinking... does this really say what numerous stories & even the authors say? I've lost about 100 lbs thru https://t.co/EQhpT3Jnvn
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/2rHqrT1taa
@DrNadolsky @dutchyankee2 @MichaelAlbertMD Step 5 showing results closer to tirze? https://t.co/6UxStFLA6t
@JamesMMiller2 @GreenValley_Guy @MattZeitlin Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/EcoUIHSYkB https://t.co/cvCXlFiZk0
@Kindke @DanielJDrucker Sorry it didn't work for you. In the trial above, 25% of ppl lost <5% of body wt. This includes the 13% who discontinued though. Together implies that 87% of ppl find it sustainable, and of those, it causes clinically significant wt loss in ~6 out of 7. https://t.co/CjDM3yTQIt
RT @NeilFlochMD: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m…
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/XQMi1tqK4Q
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
RT @NeilFlochMD: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m…
RT @NeilFlochMD: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m…
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/eI0m2zMSam
Open Access UCL Research: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial - UCL Discovery https://t.co/Z1apXe5wk1
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…
RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…
RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/xBboe8unTZ
Top story: Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/wWgnjOhRzL, see more https://t.co/W6TOkmO9Sl
RT @seanwharton: We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. W…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @NeilFlochMD: Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to…
Two-year effects of #semaglutide in adults with #overweight or #obesity: The mean change in body weight from baseline to week 104 was −15.2% in the semaglutide group (n = 152) versus −2.6% with placebo (n = 152), treatment difference of −12.6 % https://t.co/eI0m2zvP8m
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/bPnjzYrp32
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @seanwharton: We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. W…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/BKYaGNlRBT
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
We just published this paper. Sustained 15% weight loss to 2 years. #Weightloss without sustainability is not worth it. We have to strive for this. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine https://t.co/e4jqp9xiFS
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial | Nature Medicine STEP5はnature medicineからか https://t.co/RA8KYhe0Xv
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
RT @CristobMorales: https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean cha…
https://t.co/PLCtcH7Pyk Two-year effects of semaglutide in adults with overweight or obesity: the #STEP5trial “mean change in body weight from baseline to week 104 was −15.2%” @SociedadSeedo @EASOobesity @sociedadSEEN @NovoNordiskES https://t.co/JtWtaqSC33
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
RT @NatureRevEndo: Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @Nat…
Two-year effects of #semaglutide in adults with overweight or obesity: the STEP 5 trial https://t.co/MiVIZqatf6 via @NatureMedicine