Exp Mol Med October 2022 PMID 36224344

Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis.

Yiyang Xu, Guping Mao, Dianbo Long, Zengfa Deng, Ruobin Xin, Ziji Zhang, Ting Xue, Weiming Liao, Jie Xu, Yan Kang

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Peak: 4 in Oct 2022

across 2 sources since Oct 2022

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4,303

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Oct 2022 – Oct 2023

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AI synopsis

What people are saying

The majority of discussions focus on confirming the central role of circCREBBP in cartilage degradation and its potential as a therapeutic target, as evidenced by phrases like 'modulates cartilage degradation' and emphasis on the pathway involved. The tone is factual and analytical, highlighting the importance of the findings without overly emotional language, which suggests moderate interest and engagement with a focus on scientific significance.

AgreementModerate agreement

Most posts acknowledge the accuracy or significance of the research, indicating general agreement with its findings.

InterestNeutral interest

The discussions show a neutral interest level, with the repeated mentions suggesting recognition but limited personal enthusiasm.

EngagementModerate engagement

Posts include mentions of the specific pathway and the implications for cartilage health, reflecting moderate engagement.

ImpactModerate impact

Given the focus on molecular pathways and potential therapeutic targets, the discussions imply that the research could have meaningful biomedical implications.

Abstract in brief

Circular RNA CREBBP influences cartilage breakdown by activating the Smad15 pathway through the TGF2ALK1 axis, contributing to osteoarthritis progression.
Reducing circCREBBP levels enhances cartilage health by promoting extracellular matrix creation and preventing chondrocyte degeneration, while increasing its levels worsens these effects.
In a mouse model, injecting a virus that decreases circCREBBP levels helped relieve osteoarthritis symptoms, highlighting its potential as a therapeutic target.]

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All mentions

Role of Circular RNA CREBBP in Cartilage Degeneration and Osteoarthritis

Circular RNA CREBBP influences cartilage breakdown by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis, contributing to osteoarthritis progression. Reducing circCREBBP levels enhances cartilage health and…

Medicine RTCL TV · Oct 6, 2023 41 views

Jun-Liszt Li

@poppingjun · X

RT @AAVpapers: Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis https://t.…

Oct 13, 2022 · 1 share · 1,021 followers View post →

AAVpapers

@AAVpapers · X

Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis https://t.co/L5fDciGYCm https://t.co/nesKzZIsC1

Oct 13, 2022 · 1 like · 1 share · 147 followers View post →

Phage Papers

@Phage_Papers · X

Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis https://t.co/K7SHv87mwz

Oct 13, 2022 · 646 followers View post →

Adipose Papers

@adipose_papers · X

Circular RNA CREBBP modulates cartilage degradation by activating the Smad1/5 pathway through the TGFβ2/ALK1 axis https://t.co/tDt3gMYTpo https://t.co/yGm0oGM4nC

Oct 13, 2022 · 2,445 followers View post →