Bovine milk with variant β-casein types on immunological mediated intestinal changes and gut health of mice.

Abstract in brief

• The study investigated how different types of bovine milk casein, especially A2-type, affect gut health and immune responses in mice, finding that A2 milk improved intestinal structure and modulated gut microbiota without increasing inflammation.
• Consumption of A2-type casein milk led to increased levels of certain immune markers (IgG and IgE) and changes in gut microbial diversity, particularly an increase in Proteobacteria, which was linked to gut health benefits.
• The results also showed a connection between gut microbes, immune responses, and short-chain fatty acids like isobutyric acid, suggesting these factors may play a role in the gastrointestinal benefits of A2 casein milk; overall, it suggests potential dietary advantages of A2 milk for gut and immune health.]