PubHawk
October 2022 PMID 36266389

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine.

Hugo de Luca Corrêa, Artur Temizio Oppelt Raab, Thamires Marra Araújo, Lysleine Alves Deus, Andrea Lucena Reis, Fernando Sousa Honorato, Paolo Lucas Rodrigues-Silva, Rodrigo Vanerson Passos Neves, Henver Simionato Brunetta, Marcelo Alves da Silva Mori, Octávio Luiz Franco, Thiago Dos Santos Rosa

Download social card

Mentions

15
Peak: 8 in Oct 2022
across 4 sources since Oct 2022

Extended reach

170,368
potential audience

Total likes

4,851

Video views

90,726

Mentions per month

Oct 2022 – Jul 2025

Where it's discussed

  • X / Twitter11 posts
  • YouTube2 videos
  • Facebook1 posts
  • Instagram1 posts

AI synopsis

What people are saying

The discussions generally support the notion that Klotho is a promising biomarker affected by exercise, as seen in comments like 'demonstrating Klotho as an emerging exerkine,' and some participants express moderate curiosity about its implications for aging. The tone is mostly informational, with limited deep engagement or debate about methodology or broader impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, with some expressing support for the potential of Klotho as an exercise-induced molecule.

InterestModerate interest

Participants show a moderate level of curiosity, primarily engaging with the relevance of Klotho in aging and exercise effects.

EngagementNeutral engagement

Comments tend to be brief and primarily share the article's main point without deeper analysis or critique.

ImpactModerate impact

The discussions suggest recognition of the study's importance but lack indications of widespread transformative implications or practical applications.

Abstract in brief

  • The systematic review and meta-analysis found that exercise generally increases levels of circulating soluble Klotho, an antiaging protein, across different health conditions and types of training, with the exception of combined aerobic-resistance exercises.
  • The analysis included 12 studies with 621 participants aged 30 to 65, showing a significant boost in Klotho levels after at least 12 weeks of chronic exercise, suggesting it functions as an "exerkine," or exercise-induced signaling molecule.
  • The effects on Klotho depend on factors like the duration, volume, and intensity of training, indicating that different exercise protocols may influence its levels and potential antiaging benefits.
Read the full abstract

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/OjCAYjtwpm @SciReports

Oct 21, 2022 · 5 likes · 3 shares · 43,225 followers View post →
Sarcopenia_papers
@sarc_papers · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/xZCq2PN9oK https://t.co/oINtg2kJfK

Oct 24, 2022 · 2 likes · 1 share · 552 followers View post →
Nick Krontiris
@nick_krontiris · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine (open access) https://t.co/CrlqlT1Ja0

Oct 23, 2022 · 1 like · 19,465 followers View post →
Hidetaka Hamasaki
@hhamasaki78 · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/wIkbrZ8jjv

Oct 21, 2022 · 1 like · 123 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @agingdoc1: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/OjCAYjtwpm @SciReports

Oct 21, 2022 · 3 shares · 6,693 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @sarc_papers: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/xZCq2PN9oK https://t.co/oI…

Oct 24, 2022 · 1 share · 6,693 followers View post →

All mentions

Archangel
@angelorso969 · X

https://t.co/wOAfeIOR4t

Dec 23, 2024 · 212 followers View post →
Hidetaka Hamasaki
@hhamasaki78 · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine | Scientific Reports https://t.co/wIkbrZ8jjv

Jan 27, 2023 · 123 followers View post →
Howard Leonhardt
@howardleonhardt · X

https://t.co/gsMCGf7u1T https://t.co/Huq6KvfBaM

Jan 5, 2023 · 2,004 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @sarc_papers: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/xZCq2PN9oK https://t.co/oI…

Oct 24, 2022 · 1 share · 6,693 followers View post →
Sarcopenia_papers
@sarc_papers · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/xZCq2PN9oK https://t.co/oINtg2kJfK

Oct 24, 2022 · 2 likes · 1 share · 552 followers View post →
Nick Krontiris
@nick_krontiris · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine (open access) https://t.co/CrlqlT1Ja0

Oct 23, 2022 · 1 like · 19,465 followers View post →
Slawomir
@Slawomi18369321 · X

RT @agingdoc1: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/OjCAYjtwpm @SciReports

Oct 21, 2022 · 3 shares · 84 followers View post →
Protein with PE strategy
@cadospharma · X

RT @agingdoc1: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/OjCAYjtwpm @SciReports

Oct 21, 2022 · 3 shares · 420 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @agingdoc1: A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/OjCAYjtwpm @SciReports

Oct 21, 2022 · 3 shares · 6,693 followers View post →
Agingdoc
@agingdoc1 · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/OjCAYjtwpm @SciReports

Oct 21, 2022 · 5 likes · 3 shares · 43,225 followers View post →
Hidetaka Hamasaki
@hhamasaki78 · X

A systematic review and meta-analysis demonstrating Klotho as an emerging exerkine https://t.co/wIkbrZ8jjv

Oct 21, 2022 · 1 like · 123 followers View post →
¿Conocés la proteína Klotho? La llaman la “molécula de la ...
Instagram

... 10.1038/s41598-022-22123-1 Ostojic et al. Klotho stimulation via diet and creatina cerebral. Front Nutr. 2021. https://doi.org/10.3389 ...

Jul 29, 2025 View →
This study compares omnivores vs vegetarians. According to this ...
Facebook

https://doi.org/10.1038/s41598-022-22123-1 “Klotho concentration increased significantly after chronic exercise training (minimum of 12 ...

Jul 15, 2019 View →