December 2022 PMID 36285404

Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men: A Randomized Trial.

Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John Walker, Tim Matheson, Arsheen Ali, Matthew McLaughlin, Jennifer Jain, Justine Arenander, Eric Vittinghoff, Steven Batki

Mentions

70
Peak: 7 in Oct 2022
across 4 sources since Oct 2022

Extended reach

88,432
potential audience

Total likes

34

Video views

23

Mentions per month

Oct 2022 – Feb 2024

Where it's discussed

  • News41 articles
  • X / Twitter19 posts
  • Blogs8 articles
  • YouTube2 videos

AI synopsis

What people are saying

The analysis reveals strong support and high interest in the publication, with posts citing concrete research outcomes like reduced binge-drinking days (IRR=0.74) and emphasizing the potential practice-changing nature of the study, using words like 'really nice' and 'significantly'. The tone and references to clinical implications demonstrate deep engagement and a recognition of the research's meaningful impact.

AgreementModerate agreement

Most posts support the findings and effectiveness of targeted oral naltrexone for alcohol use disorder among sexual and gender minority men.

InterestHigh interest

Discussions show high engagement with the topic, with multiple posts calling the article 'really nice' or emphasizing its potential to change practice.

EngagementHigh engagement

Several discuss specific results, such as reductions in binge-drinking days and craving, indicating deep engagement.

ImpactHigh impact

The posts highlight the significant implications for clinical practice, policy, and future research, reflecting high perceived impact.

Top posts

Most liked on X and Bluesky
Michael Albert, MD
@MichaelAlbertMD · X

I love discussing pharmacology because it’s freaking cool. The art of medicine: killing too many birds with one stone: bupropion-naltrexone stimulates POMC and blocks auto-inhibitory feedback on POMC leading to lower energy homeostasis (weight https://t.co/GMAiMhaP3z

Feb 25, 2023 · 10 likes · 1 share · 15,985 followers View post →
Sandeep Nayak
@sdpnayak · X

Really nice paper, on naltrexone as needed (pre-binge or craving) for mildish alcohol use disorder https://t.co/JZO32uh7Cg

Mar 16, 2023 · 5 likes · 1 share · 2,287 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Dr. Glenn-Milo Santos and @UCSF @SF_DPH colleagues report that among sexual and gender minority individuals with mild - moderate alcohol use disorder, oral naltrexone treatment targeting periods of alcohol craving significantly reduced heavy drinking. https://t.co/Skc6FrGBYh https://t.co/U4mEVuFa7Y

Oct 27, 2022 · 4 likes · 3 shares · 11,471 followers View post →
Addiction Medicine Journal Club
@AddictionMedJC · X

We love the Episode 20 article about targeted naltrexone in sexual and gender minority men. It has changed our practices. Would it change yours? #alcoholusedisorder #naltrexone #bingedrinking #AMJC #addictionmedicine #MedEd https://t.co/BS88wQPImL

Apr 19, 2023 · 4 likes · 1 share · 354 followers View post →
HPTN
@HIVptn · X

HPTN Scholar Dr. Glenn-Milo Santos and @UCSF @SF_DPH colleagues report that among sexual and gender minority individuals with mild-moderate alcohol use disorder, oral naltrexone treatment significantly reduced heavy drinking. https://t.co/bAA6PKf54Q

Oct 31, 2022 · 3 likes · 2 shares · 9,208 followers View post →
Liz Goldberg MD ScM
@LizGoldbergMD · X

Naltrexone RCT 50mg for avg. 2.5 days/wk --> At 6 months , naltrexone ⬇️ no. of drinks/month (IRR=0.69, 95% CI=0.50, 0.97), no. of binge-drinking days (IRR=0.67, 95% CI=0.47, 0.95), and any binge drinking in the past week (IRR=0.79, 95% CI=0.63, 0.99). https://t.co/4IRoMah5IK

Mar 1, 2023 · 3 likes · 2,887 followers View post →

All mentions

Addiction Medicine Journal Club
@AddictionMedJC · X

20. Santos GM, et al. Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men: A Randomized Trial. Am J Psychiatry. 2022 Dec 1;179(12):915-926. Epub 2022 Oct 26. https://t.co/BS88wQPaxd

Apr 24, 2023 · 1 like · 354 followers View post →
Maryland Addiction Consultation Service
@Maryland_MACS · X

RT @AddictionMedJC: We love the Episode 20 article about targeted naltrexone in sexual and gender minority men. It has changed our practice…

Apr 20, 2023 · 1 share · 496 followers View post →
Addiction Medicine Journal Club
@AddictionMedJC · X

We love the Episode 20 article about targeted naltrexone in sexual and gender minority men. It has changed our practices. Would it change yours? #alcoholusedisorder #naltrexone #bingedrinking #AMJC #addictionmedicine #MedEd https://t.co/BS88wQPImL

Apr 19, 2023 · 4 likes · 1 share · 354 followers View post →
Addiction Medicine Journal Club
@AddictionMedJC · X

Episode 20 citation: Santos GM, Et al. Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men: A Randomized Trial. Am J Psychiatry. 2022 Dec 1;179(12):915-926. Epub 2022 Oct 26. https://t.co/BS88wQPImL

Apr 10, 2023 · 1 like · 354 followers View post →
Addiction Medicine Journal Club
@AddictionMedJC · X

The next Addiction Med Journal Club podcast is coming up. Get the article from AmJPsych about #naltrexone and binge-drinking. “Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men.” https://t.co/BS88wQPaxd

Apr 8, 2023 · 2 likes · 354 followers View post →
Josh Woolley MD/PhD
@thebandlab · X

RT @sdpnayak: Really nice paper, on naltrexone as needed (pre-binge or craving) for mildish alcohol use disorder https://t.co/JZO32uh7Cg

Mar 17, 2023 · 1 share · 1,969 followers View post →
Sandeep Nayak
@sdpnayak · X

Really nice paper, on naltrexone as needed (pre-binge or craving) for mildish alcohol use disorder https://t.co/JZO32uh7Cg

Mar 16, 2023 · 5 likes · 1 share · 2,287 followers View post →
NIH Common Fund
@NIH_CommonFund · X

Dr. Glenn-Milo Santos, an Early Independence awardee from our #NIHHighRisk High-Reward Research Program, and @UCSF researchers reports pill that significantly curbs #BingeDrinking by reducing #AlcoholCravings for mild to moderate alcohol use disorder. https://t.co/eIAbwTW7wM https://t.co/wPmdJmcIiU

Mar 6, 2023 · 15,376 followers View post →
Liz Goldberg MD ScM
@LizGoldbergMD · X

Naltrexone RCT 50mg for avg. 2.5 days/wk --> At 6 months , naltrexone ⬇️ no. of drinks/month (IRR=0.69, 95% CI=0.50, 0.97), no. of binge-drinking days (IRR=0.67, 95% CI=0.47, 0.95), and any binge drinking in the past week (IRR=0.79, 95% CI=0.63, 0.99). https://t.co/4IRoMah5IK

Mar 1, 2023 · 3 likes · 2,887 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

I love discussing pharmacology because it’s freaking cool. The art of medicine: killing too many birds with one stone: bupropion-naltrexone stimulates POMC and blocks auto-inhibitory feedback on POMC leading to lower energy homeostasis (weight https://t.co/GMAiMhaP3z

Feb 25, 2023 · 10 likes · 1 share · 15,985 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

I love discussing pharmacology because it’s freaking cool. The art of medicine: killing too many birds with one stone: bupropion-naltrexone blocks auto-inhibitory feedback on POMC leading to lower energy homeostasis (weight reduction). Also, it helps https://t.co/GMAiMhaP3z

Feb 25, 2023 · 15,985 followers View post →
St Thomas Fan
@StThomasStan · X

Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men: A Randomized Trial https://t.co/zrepl7QdKq

Dec 1, 2022 · 6,112 followers View post →
Frank Fuime ⛑️
@Higno_Fuime · X

RT @HIVptn: HPTN Scholar Dr. Glenn-Milo Santos and @UCSF @SF_DPH colleagues report that among sexual and gender minority individuals with m…

Oct 31, 2022 · 2 shares · 1,165 followers View post →
HPTN
@HIVptn · X

HPTN Scholar Dr. Glenn-Milo Santos and @UCSF @SF_DPH colleagues report that among sexual and gender minority individuals with mild-moderate alcohol use disorder, oral naltrexone treatment significantly reduced heavy drinking. https://t.co/bAA6PKf54Q

Oct 31, 2022 · 3 likes · 2 shares · 9,208 followers View post →
NNTonthefly
@NNTonthefly · X

New NNT→Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men: A Randomized Trial https://t.co/v9n0dUvMsU

Oct 30, 2022 · 473 followers View post →
P
@psychopharmacol · X

RCT: Naltrexone was associated with a ↓ of binge-drinking days in sexual and gender minority men with AUD (IRR=0.74; 0.56-0.98; NNT=2), weeks with any binge drinking (0.83; 0.72-0.96; 7), No. of drinks/month (0.69; 0.52-0.91; 6 for 10 drinks), and craving https://t.co/9H96U787So

Oct 27, 2022 · 575 followers View post →
UCSF School of Nursing
@UCSFNurse · X

Professor Glenn-Milo Santos & colleagues from @SF_DPH issue new report demonstrating the effectiveness of oral naltrexone treatment to reduce heavy drinking during periods of alcohol craving. Find out more: https://t.co/EZnxA7lkwv https://t.co/1YKXepLmFF

Oct 27, 2022 · 1 like · 1 share · 2,787 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Dr. Glenn-Milo Santos and @UCSF @SF_DPH colleagues report that among sexual and gender minority individuals with mild - moderate alcohol use disorder, oral naltrexone treatment targeting periods of alcohol craving significantly reduced heavy drinking. https://t.co/Skc6FrGBYh https://t.co/U4mEVuFa7Y

Oct 27, 2022 · 4 likes · 3 shares · 11,471 followers View post →
#Transgender
@Transgender_Sci · X

Targeted Oral Naltrexone for Mild to Moderate Alcohol Use Disorder Among Sexual and Gender Minority Men: A Randomized Trial https://t.co/5HuvvMfQqm #PubMed #Transgender

Oct 26, 2022 · 192 followers View post →