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Nat Microbiol November 2022 PMID 36289400

Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice.

Sabine Kienesberger, Amar Cosic, Maksym Kitsera, Sandra Raffl, Marlene Hiesinger, Eva Leitner, Bettina Halwachs, Gregor Gorkiewicz, Ronald A Glabonjat, Georg Raber, Christian Lembacher-Fadum, Rolf Breinbauer, Stefan Schild, Ellen L Zechner

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Mentions

15
Peak: 9 in Nov 2022
across 3 sources since Oct 2022

Extended reach

78,867
potential audience

Total likes

20

Video views

366

Mentions per month

Oct 2022 – Nov 2022

Where it's discussed

  • X / Twitter11 posts
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall digital discussions demonstrate high interest through shares of video summaries and mentions of the paper’s role in microbiome destabilization, with words like 'impact' and 'promotes' reflecting a focus on implications for health. The tone indicates that participants view the findings as socially and scientifically relevant, emphasizing the importance of understanding bacterial toxins in gut health and antibiotic resistance.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, emphasizing the role of tilimycin in promoting genetic changes and resistance.

InterestHigh interest

The posts actively engage with the topic, sharing summaries, videos, and references, showing high curiosity about the research implications.

EngagementModerate engagement

Participants reference specific aspects of the study, including its effects on gut microbiota and antibiotic resistance, indicating a moderate level of detailed engagement.

ImpactModerate impact

The emphasis on how this research could influence microbiome understanding and antibiotic strategies suggests a perception of meaningful impact.

Abstract in brief

  • Klebsiella spp. produce tilimycin, a DNA-alkylating enterotoxin, which harms the intestinal lining and promotes genetic instability during antibiotic treatment.
  • Analysis of mouse fecal samples reveals that tilimycin reduces gut microbial diversity and alters ecosystem composition, increasing the mutation rates in opportunistic pathogens like Klebsiella pneumoniae and Escherichia coli.
  • This study concludes that the presence of tilimycin can worsen antibiotic resistance issues and destabilize the gut microbiota.
Read the full abstract

Top posts

Most liked on X and Bluesky
Nature Microbiology
@NatureMicrobiol · X

ICYMI: Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice. By Sabine Kienesberger, Ellen Zechner & colleagues. @bienchen222 @UniGraz #klebsiella #microbiome https://t.co/1iV1LVWMgZ

Oct 27, 2022 · 11 likes · 5 shares · 74,135 followers View post →
Sabine Kienesberger-Feist
@bienchen222 · X

Check out our new video summary on how #toxigenic bacteria impact other #microbes in the #intestine published with @springerNature in @NatureMicrobiol #genotoxin #klebsiella #microbiome https://t.co/dZSUOvRUdk

Nov 1, 2022 · 3 likes · 2 shares · 30 followers View post →
Sabine Kienesberger-Feist
@bienchen222 · X

https://t.co/e82z1rsgyL #klebsiella #genotoxin #microbiome https://t.co/OSpdwSFBG0

Nov 13, 2022 · 2 likes · 1 share · 30 followers View post →
kihyun lee
@KihyunMicrobiol · X

Kienesberger, S., Cosic, A., Kitsera, M. et al. Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice. Nat Microbiol 7, 1834–1848 (2022). https://t.co/kKRmRrbzk3 ... Bad oxytoca! Bad!

Nov 3, 2022 · 1 like · 195 followers View post →
Ann Gregory, PhD
@gregory_annc · X

RT @NatureMicrobiol: ICYMI: Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in m…

Oct 27, 2022 · 5 shares · 1,596 followers View post →
Europe PMC articles
@EuropePMC · X

New from #FWFOpenAccess https://t.co/JueIRUaBQb Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice.

Oct 31, 2022 · 1,554 followers View post →

All mentions

KSt-M
@KStM14804959 · X

RT @bienchen222: https://t.co/e82z1rsgyL #klebsiella #genotoxin #microbiome https://t.co/OSpdwSFBG0

Nov 14, 2022 · 1 share · 2 followers View post →
Sabine Kienesberger-Feist
@bienchen222 · X

https://t.co/e82z1rsgyL #klebsiella #genotoxin #microbiome https://t.co/OSpdwSFBG0

Nov 13, 2022 · 2 likes · 1 share · 30 followers View post →
Katrin Schilcher
@SchilcherKatrin · X

RT @NatureMicrobiol: ICYMI: Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in m…

Nov 13, 2022 · 5 shares · 212 followers View post →
VirusesOfSuperbugs
@PhageVSuperbug · X

RT @bienchen222: Check out our new video summary on how #toxigenic bacteria impact other #microbes in the #intestine published with @spring…

Nov 5, 2022 · 2 shares · 687 followers View post →
kihyun lee
@KihyunMicrobiol · X

Kienesberger, S., Cosic, A., Kitsera, M. et al. Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice. Nat Microbiol 7, 1834–1848 (2022). https://t.co/kKRmRrbzk3 ... Bad oxytoca! Bad!

Nov 3, 2022 · 1 like · 195 followers View post →
KSt-M
@KStM14804959 · X

RT @bienchen222: Check out our new video summary on how #toxigenic bacteria impact other #microbes in the #intestine published with @spring…

Nov 1, 2022 · 2 shares · 2 followers View post →
Sabine Kienesberger-Feist
@bienchen222 · X

Check out our new video summary on how #toxigenic bacteria impact other #microbes in the #intestine published with @springerNature in @NatureMicrobiol #genotoxin #klebsiella #microbiome https://t.co/dZSUOvRUdk

Nov 1, 2022 · 3 likes · 2 shares · 30 followers View post →
Europe PMC articles
@EuropePMC · X

New from #FWFOpenAccess https://t.co/JueIRUaBQb Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice.

Oct 31, 2022 · 1,554 followers View post →
Ann Gregory, PhD
@gregory_annc · X

RT @NatureMicrobiol: ICYMI: Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in m…

Oct 27, 2022 · 5 shares · 1,596 followers View post →
KSt-M
@KStM14804959 · X

RT @NatureMicrobiol: ICYMI: Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in m…

Oct 27, 2022 · 5 shares · 2 followers View post →
Nature Microbiology
@NatureMicrobiol · X

ICYMI: Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice. By Sabine Kienesberger, Ellen Zechner & colleagues. @bienchen222 @UniGraz #klebsiella #microbiome https://t.co/1iV1LVWMgZ

Oct 27, 2022 · 11 likes · 5 shares · 74,135 followers View post →