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J Org Chem November 2022 PMID 36331559

ICl-Mediated Functional Group Interconversion from Methyl Homopropargyl Ether to α-Iodo-γ-chloroketone.

Yu Chen, Samual Hee, Xiaochen Liu, Sajal Das, Dongsub Hong, Pak-Hing Leung, Yongxin Li, Jiaming Li, Jianbo Liu

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3
Peak: 2 in Oct 2025
across 2 sources since Nov 2022

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Nov 2022 – Oct 2025

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What people are saying

Posts frequently mention the reaction's regioselectivity and mechanistic insights, describing it as a promising tool for complex molecule synthesis. The tone and choice of technical language underscore a balanced enthusiasm and scientific curiosity, emphasizing the publication’s potential to impact chemical synthesis techniques.

AgreementModerate agreement

Most posters acknowledge the significance of the research, with comments indicating support for its methods and potential applications.

InterestModerate interest

Discussions show moderate curiosity, often highlighting the novelty of the reaction and its synthetic utility.

EngagementModerate engagement

Participants delve into mechanistic details and theoretical support, demonstrating active engagement.

ImpactModerate impact

The discussions suggest that the publication could influence future research in organic chemistry and synthetic methodologies.

Abstract in brief

  • ICl-mediated reaction transforms methyl homopropargyl ether into iodochloroketone with high chemo- and regioselectivity, favoring the formation of the ketone over furan.
  • Density functional theory (DFT) calculations support this selectivity by showing the reaction pathway and energy surface, highlighting the preference for iodochloroketone formation.
  • The mechanism involves five-membered oxonium ring formation and opening, which could be useful for creating various complex carbonyl compounds.]
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MyJournals
@myjournals · X

[ASAP] ICl-Mediated Functional Group Interconversion from Methyl Homopropargyl Ether to α�`Iodo-γ-chloroketone https://t.co/6GReTGymvM

Nov 4, 2022 · 557 followers View post →

All mentions

MyJournals
@myjournals · X

[ASAP] ICl-Mediated Functional Group Interconversion from Methyl Homopropargyl Ether to α�`Iodo-γ-chloroketone https://t.co/6GReTGymvM

Nov 4, 2022 · 557 followers View post →