PubHawk
November 2022 PMID 36368306

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor.

Youwen Zhuang, Yue Wang, Bingqing He, Xinheng He, X Edward Zhou, Shimeng Guo, Qidi Rao, Jiaqi Yang, Jinyu Liu, Qingtong Zhou, Xiaoxi Wang, Mingliang Liu, Weiyi Liu, Xiangrui Jiang, Dehua Yang

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Mentions

53
Peak: 34 in Nov 2022
across 5 sources since Nov 2022

Extended reach

807,685
potential audience

Total likes

2,928

Video views

221,310

Mentions per month

Nov 2022 – May 2025

Where it's discussed

  • X / Twitter37 posts
  • News9 articles
  • Facebook4 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussions reflect a strong recognition of the study's importance, with posts calling it 'important' and describing it as a major advancement. Words like 'impressive,' 'giant step,' and 'crucial' indicate both admiration and recognition of the research's potential to influence future drug development and address public health concerns.

AgreementModerate agreement

Many posts explicitly praise the significance of the research, describing it as an 'important paper' or a 'giant step' toward understanding opioid interactions, indicating strong corroboration of its value.

InterestNeutral interest
EngagementNeutral engagement
ImpactNeutral impact

Abstract in brief

  • The study reveals the structures of human opioid receptors bound to morphine and fentanyl, highlighting key differences in how these drugs interact with the receptor, particularly at different regions of the binding pocket.
  • Morphine and fentanyl engage both TM3 and TM67 regions of the receptor, and mutations at the TM67 site can stop arrestin signaling, which is linked to some side effects.
  • The findings suggest that designing drugs to favor interactions with TM3 over TM67 could promote G protein signaling and potentially lead to safer, more targeted pain medications.]
Read the full abstract

Top posts

Most liked on X and Bluesky
mbruchas
@mbruchas · X

Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. https://t.co/E59IcfhMey . . . See also our Preview / @UWPharmacology grad student @czamorano_ in the lab. https://t.co/62SIZyUz1D. @NIDAnews

Nov 10, 2022 · 58 likes · 11 shares · 3,182 followers View post →
Cell
@CellCellPress · X

In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukvT7

Nov 13, 2022 · 52 likes · 11 shares · 263,218 followers View post →
Christophe Stove
@christophestove · X

Just out: impressive paper by Zhuang et al. in #Cell @CellCellPress: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor".

Nov 10, 2022 · 3 likes · 1 share · 1,543 followers View post →
NobuoMaita
@nob_mai · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor: Cell https://t.co/ACR1B1YwPO

Nov 10, 2022 · 3 likes · 1,071 followers View post →
β-arrestin Bot
@ArrestinBot · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/LDO7XxLitk #GPCR #signaling #pharmacology

Nov 12, 2022 · 2 likes · 739 followers View post →
proto.life
@protolifemedia · X

Understanding how they bind to their natural targets is important, the researchers say, because it provides a roadmap for designing better and potentially safer painkillers. 3/ https://t.co/28a2JBqAtr

Nov 18, 2022 · 1 like · 4,813 followers View post →

All mentions

Edelic Center for Ethnobotanical Services
@EC4ES · X

Springfield [OR] K9 finds $50K worth of fentanyl... [seized] a pound of powdered fentanyl... concealed in a children’s toy; little as 10 mg considered a lethal dose… [Image : molecular recognition of morphine and fentanyl by the human μ-opioid receptor.] https://t.co/zsd7p2I5aO https://t.co/9BBuNeSn0x

Dec 11, 2024 · 1,256 followers View post →
Cell
@CellCellPress · X

Yue has also written “Molecular recognition of morphine and fentanyl by the human μ-opioid receptor” https://t.co/T2tc42337Q

Feb 24, 2023 · 263,218 followers View post →
Yue Wang
@echo_Wongg · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Dec 10, 2022 · 11 shares · 5 followers View post →
新天地なおちゃん
@callfield · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/beVY4gcKPt

Nov 29, 2022 · 135 followers View post →
OMG Byte
@omgbyte · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/fWgMO2uJFm

Nov 23, 2022 · 7 followers View post →
proto.life
@protolifemedia · X

Understanding how they bind to their natural targets is important, the researchers say, because it provides a roadmap for designing better and potentially safer painkillers. 3/ https://t.co/28a2JBqAtr

Nov 18, 2022 · 1 like · 4,813 followers View post →
Marta Filizola
@martafilizola · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 17, 2022 · 11 shares · 2,140 followers View post →
Susruta Majumdar
@sushmajumdarlab · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 17, 2022 · 11 shares · 412 followers View post →
Surahit VC
@surahit · X

The @CellCellPress published crystal structure of mu-#opioid receptor with Fentanyl and Morphine. A giant step towards understanding the crisis that comes along with it. #GPCR research community is definitely elated to have it now after years. https://t.co/7EOf0p2KeI

Nov 16, 2022 · 241 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/4QjYUt6tCE https://t.co/C5327C8FL0

Nov 14, 2022 · 24,180 followers View post →
benishii
@benishii_ · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 14, 2022 · 11 shares · 2,604 followers View post →
Christophe Stove
@christophestove · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 14, 2022 · 11 shares · 1,543 followers View post →
Ankit Singla
@In_AnkitSingla · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 14, 2022 · 11 shares · 1,477 followers View post →
Miguel García Knight
@MiguelGarKni · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 14, 2022 · 11 shares · 410 followers View post →
Wesley B. Asher
@WesleyBAsher · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 14, 2022 · 11 shares · 282 followers View post →
Lisa Vlad
@LisaVlad2 · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 14, 2022 · 11 shares · 104 followers View post →
Pepe González
@Pepe_gonzalezm · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 13, 2022 · 11 shares · 266 followers View post →
Ji Zheng, Ph.D.
@smurfclumsy7 · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 13, 2022 · 11 shares · 57 followers View post →
Francesco Puzzo
@cicciopuz · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 13, 2022 · 11 shares · 1,396 followers View post →
Smart Strong Crawler
@LegionHu · X

RT @CellCellPress: In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukv…

Nov 13, 2022 · 11 shares · 503 followers View post →
Cell
@CellCellPress · X

In the latest issue! Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/D9AHUukvT7

Nov 13, 2022 · 52 likes · 11 shares · 263,218 followers View post →
Stef Gallas Puig, Ph.D.
@StefPuig · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 12, 2022 · 11 shares · 577 followers View post →
β-arrestin Bot
@ArrestinBot · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor https://t.co/LDO7XxLitk #GPCR #signaling #pharmacology

Nov 12, 2022 · 2 likes · 739 followers View post →
Terry Hébert
@THebertMcGill · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 11, 2022 · 11 shares · 2,188 followers View post →
Lauren Slosky
@LaurenSlosky · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 11, 2022 · 11 shares · 1,673 followers View post →
Ginevra D'Ottavio
@ginevradottavio · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 11, 2022 · 11 shares · 543 followers View post →
Ray Chou
@RealLeiZhou · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 11, 2022 · 11 shares · 222 followers View post →
Raaj Gowrishankar
@outRaajeous · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 11, 2022 · 11 shares · 650 followers View post →
Amynah Pradhan
@AmynahPradhan · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 10, 2022 · 11 shares · 1,138 followers View post →
NobuoMaita
@nob_mai · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor: Cell https://t.co/ACR1B1YwPO

Nov 10, 2022 · 3 likes · 1,071 followers View post →
Rebecca Seal
@lab_seal · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 10, 2022 · 11 shares · 892 followers View post →
Hugo Tejeda
@NeuroTejeda · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 10, 2022 · 11 shares · 2,076 followers View post →
Xavier F.
@xf_grely · X

RT @christophestove: Just out: impressive paper by Zhuang et al. in #Cell @CellCellPress: "Molecular recognition of morphine and fentanyl b…

Nov 10, 2022 · 1 share · 161 followers View post →
Christophe Stove
@christophestove · X

Just out: impressive paper by Zhuang et al. in #Cell @CellCellPress: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor".

Nov 10, 2022 · 3 likes · 1 share · 1,543 followers View post →
Catalina Zamorano
@czamorano_ · X

RT @mbruchas: Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. h…

Nov 10, 2022 · 11 shares · 58 followers View post →
mbruchas
@mbruchas · X

Important paper alert: "Molecular recognition of morphine and fentanyl by the human μ-opioid receptor" in @CellCellPress. https://t.co/E59IcfhMey . . . See also our Preview / @UWPharmacology grad student @czamorano_ in the lab. https://t.co/62SIZyUz1D. @NIDAnews

Nov 10, 2022 · 58 likes · 11 shares · 3,182 followers View post →
Dennis Kwiatkowski
@KwiatBerlin · X

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor - ScienceDirect https://t.co/QBmcgtovCX

Nov 10, 2022 · 841 followers View post →