BMC Med November 2022 PMID 36372869

Optimal target of LDL cholesterol level for statin treatment: challenges to monotonic relationship with cardiovascular events.

Masashi Sakuma, Satoshi Iimuro, Tomohiro Shinozaki, Takeshi Kimura, Yoshihisa Nakagawa, Yukio Ozaki, Hiroshi Iwata, Katsumi Miyauchi, Hiroyuki Daida, Satoru Suwa, Ichiro Sakuma, Yosuke Nishihata, Yasushi Saito, Hisao Ogawa, Masunori Matsuzaki

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Mentions

Peak: 3 in Nov 2022

across 2 sources since Nov 2022

Extended reach

26,935

potential audience

Total likes

Video views

546

Mentions per month

Nov 2022 – Jun 2024

Where it's discussed

X / Twitter4 posts
YouTube2 videos

AI synopsis

What people are saying

The discussions highlight an understanding of the research's focus on LDL-C thresholds, with posts mentioning terms like 'threshold' and 'secondary prevention,' showing analytical engagement. The tone is factual, emphasizing clinical implications, which underscores a moderate level of impact and interest in adjusting treatment approaches based on new evidence.

AgreementModerate agreement

Most discussions agree with the idea that there is a threshold LDL-C level (around 70 mg/dL) beyond which lowering LDL-C offers limited additional benefits, reflecting acceptance of the study's findings.

InterestModerate interest

Posts show moderate interest, focusing on the specific LDL-C threshold and implications for treatment, rather than general enthusiasm.

EngagementHigh engagement

Discussions are detailed, with users referencing the concept of a cutoff point and its relevance to secondary prevention, indicating deep involvement.

ImpactModerate impact

The conversations suggest a recognition of the clinical significance of the threshold, potentially influencing treatment strategies and guidelines.

Abstract in brief

Aggressive statin therapy is effective for preventing coronary artery disease (CAD), but the debate continues about how low low-density lipoprotein cholesterol (LDL-C) levels should go for optimal results.
Analysis of data from the REAL-CAD study involving over 11,000 patients indicated that a threshold LDL-C level of 70 mg/dl may exist, below which the risk of cardiovascular events does not further decrease.
This study's findings suggest that lowering LDL-C levels can reduce cardiovascular risk up to 70 mg/dl, but lowering it further does not provide additional benefits.

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All mentions

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M.Hatta

@Nothing_FD · X

https://t.co/X4XqAE7vWc

Jul 28, 2023 · 416 followers View post →

後藤礼司 Reiji Goto MD, PhD

@dr_reiji7 · X

RT @Office_j: 「CV死亡」の発生率最小は「70-<100mg/dL」、発生リスクなら「50-<100mg/dL」。 https://t.co/i99VzMN8ZX

Nov 15, 2022 · 1 share · 11,866 followers View post →

宇津貴史 /Utsu, Takashi

@Office_j · X

「CV死亡」の発生率最小は「70-<100mg/dL」、発生リスクなら「50-<100mg/dL」。 https://t.co/i99VzMN8ZX

Nov 15, 2022 · 6 likes · 1 share · 4,912 followers View post →

BMC Medicine

@BMCMedicine · X

Nov 14, 2022 · 2 likes · 9,191 followers View post →