Elife November 2022 PMID 36408801

Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality.

Ankit Sabharwal, Mark D Wishman, Roberto Lopez Cervera, MaKayla R Serres, Jennifer L Anderson, Shannon R Holmberg, Bibekananda Kar, Anthony J Treichel, Noriko Ichino, Weibin Liu, Jingchun Yang, Yonghe Ding, Yun Deng, Jean M Lacey, William J Laxen

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Mentions

Peak: 4 in Nov 2022

across 2 sources since Nov 2022

Extended reach

14,424

potential audience

Total likes

Video views

182

Mentions per month

Nov 2022 – Dec 2022

Where it's discussed

X / Twitter4 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions reveal strong support for the importance of the liver in mitochondrial diseases, with phrases like 'critical role' and mentions of genetic therapy promising a breakthrough. The tone emphasizes significance and curiosity, as seen in comments about the rigorous review process and invites to explore the full article, indicating high interest and perceived impact.

AgreementModerate agreement

Most discussions concur that the study highlights the liver's pivotal role in mitochondrial disease, with some explicitly endorsing the findings by mentioning therapeutic implications.

InterestHigh interest

The discussions demonstrate a high level of curiosity about the research, especially regarding genetic therapies and the liver's involvement, indicated by references to the article and detailed comments.

EngagementModerate engagement

Participants show moderate engagement by sharing additional context, like the review process and inviting others to learn more, which goes beyond superficial reactions.

ImpactHigh impact

The debates reflect a belief that this research could influence future treatments and understanding of mitochondrial diseases, emphasizing its significant potential.

Abstract in brief

Mitochondrial disorders exhibit a complex range of symptoms that complicate understanding of these organelles' roles in health and disease, particularly in cases like Leigh Syndrome French Canadian Type (LSFC).
Researchers developed a novel genetic model using zebrafish, which mimics key characteristics of LSFC, including liver dysfunction and metabolic issues, by targeting specific genetic variations.
The study found that liver-specific genetic therapies could effectively reverse the symptoms in the zebrafish model, highlighting the liver's important role in the disease's progression.

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All mentions

Gene Therapy Model Highlights Liver’s Role in Leigh Syndrome

Researchers developed a zebrafish model for Leigh Syndrome French Canadian Type, mimicking key symptoms like liver dysfunction. Using targeted genetic therapy, they repaired mutations and improved metabolic issues…

Labforward · Nov 25, 2022 182 views

Zebrafish Rock!

@ZebrafishRock · X

Dec 22, 2022 · 4 likes · 11,736 followers View post →

Stephen C. Ekker, Ph.D.

@scekker · X

More here: https://t.co/g5OV4EdUPS The eLife review experience was rigorous but also forgiving as we dealt with some technical delays.

Nov 25, 2022 · 4 likes · 2,367 followers View post →

Labforward

@labforward · X

If you're interested in learning more, you can find the full article, published in @eLife

Nov 25, 2022 · 1 like · 136 followers View post →

Helena Paris

@Educators_Link · X

Genetic therapy in a mitochondrial disease model suggests a critical role for liver dysfunction in mortality https://t.co/5QL4shiQax

Nov 21, 2022 · 4 followers View post →