Cell Rep November 2022 PMID 36417879

Calreticulin mutations affect its chaperone function and perturb the glycoproteome.

Patrick M Schürch, Liliana Malinovska, Mohammad Hleihil, Marco Losa, Mara C Hofstetter, Mattheus H E Wildschut, Veronika Lysenko, Asvin K K Lakkaraju, Christina A Maat, Dietmar Benke, Adriano Aguzzi, Bernd Wollscheid, Paola Picotti, Alexandre P A Theocharides

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Mentions

Peak: 7 in Nov 2022

across 2 sources since Nov 2022

Extended reach

196,676

potential audience

Total likes

Video views

206

Mentions per month

Nov 2022 – Jun 2023

Where it's discussed

X / Twitter7 posts
YouTube2 videos

AI synopsis

What people are saying

The discussions reflect keen interest, with many users highlighting the role of CALR mutations in disrupting protein folding and their connection to myeloproliferative diseases, using words like 'affect,' 'perturb,' and 'disrupt.' The tone suggests appreciation of the research's importance, though with some comments indicating curiosity about broader applications, contributing to the moderate impact and engagement scores.

AgreementModerate agreement

The majority of discussions acknowledge the significance of the research findings, indicating general support for its conclusions.

InterestHigh interest

Participants show a high level of interest, often emphasizing the relevance of CALR mutations in disease mechanisms.

EngagementModerate engagement

Discussions include references to how the mutations affect protein function and disease implications, reflecting a moderate depth of engagement.

ImpactModerate impact

Users recognize that these findings could influence future research or therapeutics, but the discussions remain somewhat preliminary.

Abstract in brief

CALR is a chaperone protein that helps other proteins achieve their proper structure and is retained in the endoplasmic reticulum; mutations in CALR are linked to myeloproliferative neoplasms (MPNs).
Research using mass spectrometry shows that CALR mutations affect the structure and levels of glycoproteins in affected cells, with homozygous mutations causing more significant changes than heterozygous ones.
The study demonstrates that the loss of function in mutated CALR disrupts glycoprotein integrity, leading to misfolded proteins like myeloperoxidase (MPO) in cells with homozygous CALR mutations.

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All mentions

Impact of Calreticulin Mutations on Myeloproliferative Neoplasms

Calreticulin mutations in MPN patients affect protein folding and glycoprotein levels, with homozygous mutations causing more significant disruptions, potentially leading to misfolded proteins like MPO.

Informative · May 31, 2023 141 views

Impact of Calreticulin Mutations on Protein Folding and Glycoproteome Disruption

Calreticulin mutation affects chaperone functions and perturbs the glycoproteome. Research using mass spectrometry reveals how mutations impair glycoprotein structure and levels, especially in homozygous cases…

Informative · Jun 1, 2023 65 views

Dr. Shashank Joshi

@AskDrShashank · X

RT @CellReports: Calreticulin mutations affect its chaperone function and perturb the glycoproteome https://t.co/IkTB1IwzX5

Nov 28, 2022 · 1 share · 32,512 followers View post →

Cell Reports

@CellReports · X

Calreticulin mutations affect its chaperone function and perturb the glycoproteome https://t.co/IkTB1IwzX5

Nov 28, 2022 · 7 likes · 1 share · 142,278 followers View post →

M.Safa Karagoez

@mskaragoez · X

RT @cell_club: Calreticulin mutations affect its chaperone function and perturb the glycoproteome https://t.co/A87RjzXiKl

Nov 22, 2022 · 2 shares · 1,992 followers View post →

@ayanosatoh · X

RT @cell_club: Calreticulin mutations affect its chaperone function and perturb the glycoproteome https://t.co/A87RjzXiKl

Nov 22, 2022 · 2 shares · 628 followers View post →

Cell Biology J-Club

@cell_club · X

Calreticulin mutations affect its chaperone function and perturb the glycoproteome https://t.co/A87RjzXiKl

Nov 22, 2022 · 6 likes · 2 shares · 6,169 followers View post →

Manish Chamoli

@manish_chamoli · X

RT @ShorterLab: Calreticulin mutations affect its chaperone function and perturb the glycoproteome: https://t.co/FBM3rvhmMq

Nov 22, 2022 · 1 share · 773 followers View post →

ShorterLab

@ShorterLab · X

Calreticulin mutations affect its chaperone function and perturb the glycoproteome: https://t.co/FBM3rvhmMq

Nov 22, 2022 · 6 likes · 1 share · 12,099 followers View post →