Elife December 2022 PMID 36453722

Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology.

Elizabeth A Bearce, Zoe H Irons, Johnathan R O'Hara-Smith, Colin J Kuhns, Sophie I Fisher, William E Crow, Daniel T Grimes

Download social card

Mentions

35
Peak: 12 in Feb 2023
across 4 sources since Aug 2022

Extended reach

1,831,826
potential audience

Total likes

83

Video views

80

Mentions per month

Aug 2022 – May 2023

Where it's discussed

  • X / Twitter28 posts
  • YouTube3 videos
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

Several discussions highlight the importance of the peptides Urp1 and Urp2, with phrases like 'beautifully executed' and 'helps us understand cues' reflecting admiration and curiosity. Words such as 'control' and 'may provide insight' reveal how participants see the study's potential impact on medical research, conveying both respect and anticipation for future implications.

AgreementModerate agreement

Most posts express support and appreciation for the study, describing it as 'beautifully executed' and emphasizing its relevance to understanding scoliosis.

InterestHigh interest

Posts demonstrate high curiosity, especially when connecting the research to broader topics like spine deformities and potential medical implications.

EngagementHigh engagement

Participants actively discuss the significance of the peptides and their role in spine morphology, with some referencing potential applications or implications, indicating deep engagement.

ImpactModerate impact

There is a perception that this research could significantly influence understanding of spinal conditions and inspire further studies, though some posts remain optimistic without definitive claims.

Abstract in brief

  • The study found that two peptides, Urp1 and Urp2, are crucial for maintaining proper spine shape in zebrafish, and losing them causes spinal curves similar to human conditions like scoliosis.
  • These peptides are produced by neurons in the spinal cord, and their absence leads to curvature specifically in the tail region during adolescence; mutations in their receptor, Uts2r3, cause similar effects.
  • The research also showed that the physical breakdown of the Reissner fiber, a structure in the spinal canal, relates to curve formation in some mutants, but not in Urp-deficient zebrafish, indicating a different, independent mechanism for spine curvature.]

Top posts

Most liked on X and Bluesky
eLife - the journal
@eLife · X

“This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd https://t.co/f30ay8BDh8

Feb 6, 2023 · 24 likes · 2 shares · 171,686 followers View post →
Daniel T Grimes
@DanTGrimes · X

Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish spine. This helps us understand cues underlying spine shape and may provide insight into spinal curvatures like #scoliosis. https://t.co/GpjL0cCHcU

Dec 1, 2022 · 22 likes · 6 shares · 1,348 followers View post →
Phys.org
@physorg_com · X

Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 3, 2023 · 15 likes · 5 shares · 1,023,925 followers View post →
eLife - the journal
@eLife · X

“This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd https://t.co/g2wAUIUPPS

Feb 11, 2023 · 13 likes · 2 shares · 171,686 followers View post →
Zebrafish Rock!
@ZebrafishRock · X

Publications (8 of 20) @uribelabrice (ENS/migration) https://t.co/HrcbooYSDY @DanTGrimes (Urotensin II-related peptides/Spine morphology/Scoliosis) https://t.co/hUAgiOVt6W @MokalledLab @vishnums007 (Myostatin/Spinal cord regeneration) https://t.co/d0JAvHGmbF 13/53

Dec 22, 2022 · 6 likes · 11,727 followers View post →
bioRxiv
@biorxivpreprint · X

#PeerReview from @ReviewCommons of

Sep 30, 2022 · 1 like · 1 share · 136,899 followers View post →

All mentions

Usha Kiran Sahoo || ଉଷା କିରଣ ସାହୁ
@ushakiransahoo1 · X

RT @eLife: “This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd…

Mar 11, 2023 · 2 shares · 130 followers View post →
Streisinger
@bstreisinger · X

Dec 2022 Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology https://t.co/IRTxODepAf #AIS #CSF #Idiopathicscoliosis #cerebrospinalfluid https://t.co/1qrQkrBaSo

Mar 1, 2023 · 113 followers View post →
BioDynaMo
@BioDynaMo_org · X

RT @eLife: “This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd…

Feb 13, 2023 · 2 shares · 161 followers View post →
eLife - the journal
@eLife · X

“This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd https://t.co/g2wAUIUPPS

Feb 11, 2023 · 13 likes · 2 shares · 171,686 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @physorg_com: Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 10, 2023 · 5 shares · 1,786 followers View post →
Daniel T Grimes
@DanTGrimes · X

RT @eLife: “This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd…

Feb 7, 2023 · 2 shares · 1,348 followers View post →
Bryson Ricamona
@brysontbr · X

RT @eLife: “This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd…

Feb 7, 2023 · 2 shares · 97 followers View post →
eLife - the journal
@eLife · X

“This is a beautifully executed study on the role of Urp signaling in spine morphogenesis in zebrafish.” https://t.co/IJCkyFsMSd https://t.co/f30ay8BDh8

Feb 6, 2023 · 24 likes · 2 shares · 171,686 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology | eLife https://t.co/7aeU8kN7LZ

Feb 3, 2023 · 2,569 followers View post →
seandy
@sheesashiworld · X

RT @physorg_com: Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 3, 2023 · 5 shares · 317 followers View post →
Shapley Fürskyn
@shiva137 · X

RT @physorg_com: Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 3, 2023 · 5 shares · 217 followers View post →
Mr. Cauthers
@MrCauthers · X

RT @physorg_com: Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 3, 2023 · 5 shares · 128 followers View post →
Phys.org Biology
@physorg_biology · X

RT @physorg_com: Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 3, 2023 · 5 shares · 8,223 followers View post →
Phys.org
@physorg_com · X

Zebrafish research helps reveal the origins of scoliosis @elife https://t.co/EZW6OTbS87 https://t.co/zXM0pYq8p3

Feb 3, 2023 · 15 likes · 5 shares · 1,023,925 followers View post →
zebrafishdevpapers
@zebrafishdev · X

Urotensin II-related peptides, Urp1 and Urp2, control zebrafish spine morphology https://t.co/kab2M8LfU2

Jan 12, 2023 · 34 followers View post →
Zebrafish Rock!
@ZebrafishRock · X

Publications (8 of 20) @uribelabrice (ENS/migration) https://t.co/HrcbooYSDY @DanTGrimes (Urotensin II-related peptides/Spine morphology/Scoliosis) https://t.co/hUAgiOVt6W @MokalledLab @vishnums007 (Myostatin/Spinal cord regeneration) https://t.co/d0JAvHGmbF 13/53

Dec 22, 2022 · 6 likes · 11,727 followers View post →
Dr. Damanpreet Singh
@damanz1984 · X

RT @DanTGrimes: Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish…

Dec 2, 2022 · 6 shares · 30 followers View post →
Amy Robbins
@ZfishAmy · X

RT @DanTGrimes: Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish…

Dec 2, 2022 · 6 shares · 252 followers View post →
Patrick Finn Horve
@PatrickHorve · X

RT @DanTGrimes: Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish…

Dec 1, 2022 · 6 shares · 1,232 followers View post →
Louis Prahl
@lsprahl · X

RT @DanTGrimes: Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish…

Dec 1, 2022 · 6 shares · 1,286 followers View post →
Inyoung Jeong (Jung)
@InyoungJeong2 · X

RT @DanTGrimes: Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish…

Dec 1, 2022 · 6 shares · 315 followers View post →
Zebrafish Rock!
@ZebrafishRock · X

RT @DanTGrimes: Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish…

Dec 1, 2022 · 6 shares · 11,727 followers View post →
Daniel T Grimes
@DanTGrimes · X

Our latest paper is out today in @eLife. We show that Urotensin II-related peptides control the morphology of the zebrafish spine. This helps us understand cues underlying spine shape and may provide insight into spinal curvatures like #scoliosis. https://t.co/GpjL0cCHcU

Dec 1, 2022 · 22 likes · 6 shares · 1,348 followers View post →
Review Commons
@ReviewCommons · X

"Urotensin II-Related Peptides, Urp1 and Urp2, Control #Zebrafish Spine Morphology" #RefereedPreprint Elizabeth Bearce, @DanTGrimes et al @uoregon https://t.co/S6lmlTgMXE https://t.co/GhJhUycrL6

Oct 28, 2022 · 5,271 followers View post →
Review Commons
@ReviewCommons · X

RT @biorxivpreprint: #PeerReview from @ReviewCommons of

Oct 1, 2022 · 1 share · 5,271 followers View post →
bioRxiv
@biorxivpreprint · X

#PeerReview from @ReviewCommons of

Sep 30, 2022 · 1 like · 1 share · 136,899 followers View post →
bioRxiv
@biorxivpreprint · X

#PeerReview from @ReviewCommons of

Sep 30, 2022 · 136,899 followers View post →
bioRxiv
@biorxivpreprint · X

Urotensin II-Related Peptides, Urp1 and Urp2, Control Zebrafish Spine Morphology https://t.co/AAOB5tuS1y #bioRxiv

Aug 15, 2022 · 136,899 followers View post →