@chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV
Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies.
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Dec 2022 – Feb 2025Where it's discussed
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AI synopsis
What people are saying
The discussions reflect positive reception and curiosity about the article, with comments like 'Very exciting' and mentions of related work at MIT, along with references to specific brain regions impacted by the stimulation, all of which show a genuine interest and belief in the potential impact of gamma frequency sensory stimulation in Alzheimer’s treatment.
Most discussions express support and enthusiasm for the findings, referencing the safety and potential benefits, indicating a generally positive stance.
The discussions demonstrate high interest through mentions of detailed studies, related work at MIT, and calls for further research, showing curiosity and engagement.
Participants reference specific neuroscience concepts and clinical outcomes, indicating a moderate level of deep engagement with the research details.
The discussions highlight perceived significance of the research, with references to potential effects on treatment and future studies, suggesting a recognition of its importance.
Abstract in brief
- Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz has been shown to reduce Alzheimer’s disease pathology, prevent brain atrophy, and improve behavior in mouse models.
- Two clinical studies evaluated GENUS: a Phase 1 study confirmed its safety and feasibility in cognitively normal volunteers and mild AD patients, while a Phase 2A pilot study tested chronic daily stimulation in patients with mild AD, finding it well-tolerated and effective.
- After 3 months of daily GENUS, patients demonstrated less brain atrophy, improved brain connectivity, better memory performance, and enhanced daily activity rhythms compared to the placebo group.
Top posts
Most liked on X and BlueskyOur division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publication considering Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients. https://t.co/rFpmenXNlt
研究論文(画像
Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies Diane Chan, @eboyden3, @DrLiHueiTsai https://t.co/kNKLf1gBLi https://t.co/4RTkcbmiAZ
https://t.co/SWe3BjxeNC
"After 3 months of daily stimulation, the group receiving 40Hz stimulation showed (i) lesser hippocampal atrophy, (ii) increased functional connectivity in the default mode network as well as with the medial visual network" #Alzheimer #stimulation https://t.co/ptU0vfRjpR
All mentions
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研究論文(画像
RT @ErinSandersNP: @chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV
RT @agingdoc1: Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies…
Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies Diane Chan, @eboyden3, @DrLiHueiTsai https://t.co/kNKLf1gBLi https://t.co/4RTkcbmiAZ
For folks really interested in the impact on humans see the paper doi.org/10.1371/journal.pone.0278412 And when evaluating prospective treatments, look for changes in MMSE (higher is better), MoCA (higher), ADAS-Cog (lower), or CDR-sob (lower). In this case, the changes in Table 4.
{Fighting Stigma} Brain stimulation with 40 Hz heterochromatic flicker extended beyond red, green, and blue: This study also ... Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies. https://t.co/2okaBn2w0O
Here is one study (12/2022) involving Cognito Therapeutics, one of the companies mentioned in the WSJ article. More on their site...https://t.co/2T3jWjCl26 https://t.co/hQBqkFrTSc https://t.co/a3YIIRXVdv
RT @ErinSandersNP: @chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV
@chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV
RT @UIowaPeds: Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publ…
RT @UIowaPeds: Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publ…
RT @UIowaPeds: Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publ…
Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publication considering Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients. https://t.co/rFpmenXNlt
https://t.co/NI2vggAi6A
https://t.co/8Vd3cIajoV
"After 3 months of daily stimulation, the group receiving 40Hz stimulation showed (i) lesser hippocampal atrophy, (ii) increased functional connectivity in the default mode network as well as with the medial visual network" #Alzheimer #stimulation https://t.co/ptU0vfRjpR
Very exciting. Looking fwd to seeing further studies. https://t.co/1GhWcf6Rb3
https://t.co/SWe3BjxeNC
"... 40Hz GENUS was safe and effectively induced entrainment in both cortical regions and other cortical and subcortical structures such as the hippocampus, amygdala, insula, and gyrus rectus." https://t.co/sszSv01t5d https://t.co/PFkjpTo1XK