December 2022 PMID 36454969

Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies.

Diane Chan, Ho-Jun Suk, Brennan L Jackson, Noah P Milman, Danielle Stark, Elizabeth B Klerman, Erin Kitchener, Vanesa S Fernandez Avalos, Gabrielle de Weck, Arit Banerjee, Sara D Beach, Joel Blanchard, Colton Stearns, Aaron D Boes, Brandt Uitermarkt

Mentions

49
Peak: 6 in Jan 2023
across 5 sources since Dec 2022

Extended reach

123,141
potential audience

Total likes

84

Video views

1,242

Mentions per month

Dec 2022 – Feb 2025

Where it's discussed

  • News22 articles
  • X / Twitter18 posts
  • Blogs6 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect positive reception and curiosity about the article, with comments like 'Very exciting' and mentions of related work at MIT, along with references to specific brain regions impacted by the stimulation, all of which show a genuine interest and belief in the potential impact of gamma frequency sensory stimulation in Alzheimer’s treatment.

AgreementModerate agreement

Most discussions express support and enthusiasm for the findings, referencing the safety and potential benefits, indicating a generally positive stance.

InterestHigh interest

The discussions demonstrate high interest through mentions of detailed studies, related work at MIT, and calls for further research, showing curiosity and engagement.

EngagementModerate engagement

Participants reference specific neuroscience concepts and clinical outcomes, indicating a moderate level of deep engagement with the research details.

ImpactModerate impact

The discussions highlight perceived significance of the research, with references to potential effects on treatment and future studies, suggesting a recognition of its importance.

Abstract in brief

  • Non-invasive Gamma ENtrainment Using Sensory stimulation (GENUS) at 40Hz has been shown to reduce Alzheimer’s disease pathology, prevent brain atrophy, and improve behavior in mouse models.
  • Two clinical studies evaluated GENUS: a Phase 1 study confirmed its safety and feasibility in cognitively normal volunteers and mild AD patients, while a Phase 2A pilot study tested chronic daily stimulation in patients with mild AD, finding it well-tolerated and effective.
  • After 3 months of daily GENUS, patients demonstrated less brain atrophy, improved brain connectivity, better memory performance, and enhanced daily activity rhythms compared to the placebo group.

Top posts

Most liked on X and Bluesky
Erin C. Sanders, MSN, WHNP (She/Her)
@ErinSandersNP · X

@chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV

Apr 17, 2023 · 9 likes · 2 shares · 18,601 followers View post →
UI Stead Family Department of Pediatrics
@UIowaPeds · X

Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publication considering Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients. https://t.co/rFpmenXNlt

Jan 27, 2023 · 5 likes · 3 shares · 1,292 followers View post →
yin_yang_tuning
@yin_yang_tuning · X

研究論文(画像

Feb 10, 2025 · 5 likes · 115 followers View post →
Agingdoc
@agingdoc1 · X

Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies Diane Chan, @eboyden3, @DrLiHueiTsai https://t.co/kNKLf1gBLi https://t.co/4RTkcbmiAZ

Mar 15, 2024 · 4 likes · 2 shares · 41,794 followers View post →
David Jones
@DavidJonesBrain · X

https://t.co/SWe3BjxeNC

Dec 6, 2022 · 2 likes · 1,630 followers View post →
Researching the Brain
@Brain_Database · X

"After 3 months of daily stimulation, the group receiving 40Hz stimulation showed (i) lesser hippocampal atrophy, (ii) increased functional connectivity in the default mode network as well as with the medial visual network" #Alzheimer #stimulation https://t.co/ptU0vfRjpR

Dec 9, 2022 · 1 like · 1,038 followers View post →

All mentions

yin_yang_tuning
@yin_yang_tuning · X

研究論文(画像

Feb 10, 2025 · 5 likes · 115 followers View post →
Tinu Abayomi-Paul aka Empress of Twerk. NO DMs
@Tinu · X

RT @ErinSandersNP: @chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV

Jun 26, 2024 · 2 shares · 50,372 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies…

Mar 16, 2024 · 2 shares · 132 followers View post →
Agingdoc
@agingdoc1 · X

Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia patients: Results of feasibility and pilot studies Diane Chan, @eboyden3, @DrLiHueiTsai https://t.co/kNKLf1gBLi https://t.co/4RTkcbmiAZ

Mar 15, 2024 · 4 likes · 2 shares · 41,794 followers View post →
Dave Blake
@blakestah.bsky.social · Bluesky

For folks really interested in the impact on humans see the paper doi.org/10.1371/journal.pone.0278412 And when evaluating prospective treatments, look for changes in MMSE (higher is better), MoCA (higher), ADAS-Cog (lower), or CDR-sob (lower). In this case, the changes in Table 4.

Mar 11, 2024 · 1 like · 1 share View post →
STIGMABASE
@stigmabase · X

{Fighting Stigma} Brain stimulation with 40 Hz heterochromatic flicker extended beyond red, green, and blue: This study also ... Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies. https://t.co/2okaBn2w0O

Jan 25, 2024 · 1,122 followers View post →
Christopher A. Szpryngel, PhD
@szp_per · X

Here is one study (12/2022) involving Cognito Therapeutics, one of the companies mentioned in the WSJ article. More on their site...https://t.co/2T3jWjCl26 https://t.co/hQBqkFrTSc https://t.co/a3YIIRXVdv

Aug 18, 2023 · 34 followers View post →
Daya G.✨
@4evrstardancer · X

RT @ErinSandersNP: @chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV

Apr 17, 2023 · 2 shares · 4,147 followers View post →
Erin C. Sanders, MSN, WHNP (She/Her)
@ErinSandersNP · X

@chydorina @PaulRKeeble @Omnipemf Reminds me of the work from Dr. Li Tsai at MIT in Alzheimer’s https://t.co/ICOJKPr9yV

Apr 17, 2023 · 9 likes · 2 shares · 18,601 followers View post →
Scott Fedler
@thesfedler · X

RT @UIowaPeds: Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publ…

Jan 27, 2023 · 3 shares · 142 followers View post →
Liberty Taeger
@libertytaeger · X

RT @UIowaPeds: Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publ…

Jan 27, 2023 · 3 shares · 51 followers View post →
University of Iowa Pediatric Neurology
@uiowapedsneuro · X

RT @UIowaPeds: Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publ…

Jan 27, 2023 · 3 shares · 524 followers View post →
UI Stead Family Department of Pediatrics
@UIowaPeds · X

Our division director of Child Neurology, Aaron Boes, MD, PhD (@boeslab), collaborated with multiple colleagues on this publication considering Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients. https://t.co/rFpmenXNlt

Jan 27, 2023 · 5 likes · 3 shares · 1,292 followers View post →
august smorgasborg
@mobert_roses · X

https://t.co/NI2vggAi6A

Jan 9, 2023 · 1 like · 173 followers View post →
新天地なおちゃん
@callfield · X

https://t.co/8Vd3cIajoV

Jan 1, 2023 · 135 followers View post →
Researching the Brain
@Brain_Database · X

"After 3 months of daily stimulation, the group receiving 40Hz stimulation showed (i) lesser hippocampal atrophy, (ii) increased functional connectivity in the default mode network as well as with the medial visual network" #Alzheimer #stimulation https://t.co/ptU0vfRjpR

Dec 9, 2022 · 1 like · 1,038 followers View post →
Raya Shu | RNA nerd
@raya_shu · X

Very exciting. Looking fwd to seeing further studies. https://t.co/1GhWcf6Rb3

Dec 7, 2022 · 118 followers View post →
David Jones
@DavidJonesBrain · X

https://t.co/SWe3BjxeNC

Dec 6, 2022 · 2 likes · 1,630 followers View post →
Molec Path
@MolecPath · X

"... 40Hz GENUS was safe and effectively induced entrainment in both cortical regions and other cortical and subcortical structures such as the hippocampus, amygdala, insula, and gyrus rectus." https://t.co/sszSv01t5d https://t.co/PFkjpTo1XK

Dec 2, 2022 · 433 followers View post →