CPT Pharmacometrics Syst Pharmacol May 2023 PMID 36456539

Mechanistic modeling of drug products applied to the skin: A workshop summary report.

Eleftheria Tsakalozou, Khondoker Alam, Priyanka Ghosh, Jessica Spires, Sebastian Polak, Lanyan Fang, Srinivasa Sammeta, Ping Zhao, Sumit Arora, Sam G Raney

Mentions

2
Peak: 1 in Jun 2023
across 2 sources since Jun 2023

Extended reach

691
potential audience

Total likes

4

Video views

53

Mentions per month

Jun 2023 – Aug 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions express a moderate consensus on the value of mechanistic modeling in improving drug development, with posts mentioning workshops on various drug forms like ophthalmic and nasal products, and emphasizing the potential for advancing generic skin treatments. The tone reflects cautious optimism, highlighting the significance of these methods for future pharmaceutical innovations.

AgreementModerate agreement

Many discussions acknowledge the value of the workshop and modeling techniques, showing moderate agreement about the importance of this approach.

InterestModerate interest

Posts demonstrate a general interest in the topic, especially regarding how modeling can help develop skin drugs, but some show limited enthusiasm.

EngagementNeutral engagement

Most comments remain at a surface level, referencing the workshop topics broadly without deep dives into technical details.

ImpactModerate impact

Participants believe the research and modeling approaches discussed could positively influence the development and approval of dermatological drugs, indicating a recognized but not overwhelming impact.

Abstract in brief

  • The development of generic topical skin drugs is challenging because measuring how much of the active ingredient reaches the target area in the skin is difficult, and there is often no clear link between skin and blood drug levels.
  • The FDA has initiated research programs aimed at improving access to affordable and effective dermatological generics by using modeling and simulation techniques to find new ways to demonstrate drug bioequivalence.
  • This report highlights insights from a 2021 FDA workshop that discussed how mechanistic modeling can help in the development and regulatory approval process of generic skin medications.]

Top posts

Most liked on X and Bluesky
Rosa for QSP
@RosaQSP · X

Mechanistic Modeling workshop reports: Ophthalmic, nasal, injectable, and implant generic drug products https://t.co/2ATKNqn3Xs Drug products applied to the skin https://t.co/IRt28uWNLi Generic orally inhaled drug products https://t.co/1qmFU4Uk7U

Jun 4, 2023 · 2 likes · 1 share · 637 followers View post →

All mentions

Rosa for QSP
@RosaQSP · X

Mechanistic Modeling workshop reports: Ophthalmic, nasal, injectable, and implant generic drug products https://t.co/2ATKNqn3Xs Drug products applied to the skin https://t.co/IRt28uWNLi Generic orally inhaled drug products https://t.co/1qmFU4Uk7U

Jun 4, 2023 · 2 likes · 1 share · 637 followers View post →