Exp Hematol February 2023 PMID 36481429

Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells.

Masatoshi Ikeda, Hiroki Kato, Hiroki Shima, Mitsuyo Matsumoto, Eijiro Furukawa, Yan Yan, Ruiqi Liao, Jian Xu, Akihiko Muto, Tohru Fujiwara, Hideo Harigae, Emery H Bresnick, Kazuhiko Igarashi

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Mentions

Peak: 7 in Jan 2024

across 2 sources since Dec 2022

Extended reach

11,758

potential audience

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Video views

279

Mentions per month

Dec 2022 – Jan 2024

Where it's discussed

X / Twitter9 posts
YouTube2 videos

AI synopsis

What people are saying

These discussions express high interest and moderate engagement, noting the study's focus on heme's regulatory role in mitophagy during erythropoiesis. For example, mentions of the findings being 'out in Experimental Hematology' and references to authors highlight engagement with the research’s content and significance, while the tone conveys anticipation of its impact on future research and understanding of red blood cell formation.

AgreementModerate agreement

Most discussions acknowledge the importance of the study, especially highlighting the regulatory role of heme in erythroid cell differentiation.

InterestHigh interest

The posts show strong interest, referencing the study’s findings and emphasizing the significance of heme and mitochondrial clearance.

EngagementModerate engagement

Participants engage with the content by sharing insights, mentioning authors, and discussing broader implications.

ImpactModerate impact

The discussions suggest potential influence on understanding erythropoiesis, though the impact on clinical practice remains speculative.

Abstract in brief

The study explores how mitochondria are initially needed for heme production in erythroblasts but then must be degraded during final red blood cell formation, involving a biphasic process regulated by iron, heme, and the transcription factor GATA1.
Heme promotes the expression of GATA1-regulated genes that are involved in mitophagy, leading to the clearance of mitochondria during erythroid cell differentiation, especially through heme-dependent mechanisms.
The findings suggest that mitochondria play a dual role: first in supporting heme synthesis and later being targeted for degradation via mitophagy, with heme itself acting as a key signal in this regulation.]

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Heme-Driven Regulation of Mitochondria Removal in Red Blood Cell Development

A short digest of the publication by Ikeda and Kato et al in Feb 2023. Heme triggers mitochondrial removal through autophagy during red blood cell differentiation, with mitochondria initially supporting heme synthesis…

Biochem Med Tohoku · Jan 13, 2024 188 views

Heme-Regulated Mitophagy in Red Blood Cell Development.

This video explores how heme triggers mitochondrial removal during erythroid cell differentiation by promoting mitophagy, a critical process for red blood cell maturation, involving iron, heme, and GATA1 regulation.

Biochem Med Tohoku · Jan 13, 2024 92 views

小山内崇（t.osanai）

@osanai_meiji · X

RT @kazuigarashi: YouTube始めました https://t.co/FMNZqMDXar

Jan 17, 2024 · 4 shares · 3,510 followers View post →

Yasushi Tamura

@Tamura_Lab · X

RT @kazuigarashi: YouTube始めました https://t.co/FMNZqMDXar

Jan 17, 2024 · 4 shares · 2,596 followers View post →

TN_biostructchem☆

@BioStructChem · X

RT @kazuigarashi: YouTube始めました https://t.co/FMNZqMDXar

Jan 17, 2024 · 4 shares · 1,932 followers View post →

Atsushi_Tanaka_PhD

@ATP_1976 · X

RT @kazuigarashi: YouTube始めました https://t.co/FMNZqMDXar

Jan 17, 2024 · 4 shares · 576 followers View post →

Kazuhiko Igarashi

@kazuigarashi · X

YouTube始めました https://t.co/FMNZqMDXar

Jan 13, 2024 · 9 likes · 4 shares · 1,114 followers View post →

IronBiologyBot

@IronBiologyBot · X

RT @IronBiologyBot: Heme-dependent induction of mitophagy program during murine erythroid cell differentiation https://t.co/95Jyw1g519 #Iro…

Dec 16, 2022 · 1 share · 288 followers View post →

biochem_tohoku_med

@EpiGrn · X

RT @kazuigarashi: Our findings on the regulatory function of heme from the metabolism-differentiation project is out in Experimental Hemato…

Dec 13, 2022 · 1 share · 14 followers View post →

Kazuhiko Igarashi

@kazuigarashi · X

Dec 13, 2022 · 5 likes · 1 share · 1,114 followers View post →

IronBiologyBot

@IronBiologyBot · X

Heme-dependent induction of mitophagy program during murine erythroid cell differentiation https://t.co/95Jyw1g519 #IronBiology #BioIron #Iron

Dec 9, 2022 · 1 share · 288 followers View post →

Heme-dependent induction of mitophagy program during differentiation of murine erythroid cells.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Heme-Driven Regulation of Mitochondria Removal in Red Blood Cell Development

Heme-Regulated Mitophagy in Red Blood Cell Development.