December 2022 PMID 36505931

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point.

Brad Screnci, Lewis J Stafford, Trevor Barnes, Kristen Shema, Samantha Gilman, Rebecca Wright, Suzie Al Absi, Tim Phillips, Charles Azuelos, Katherine Slovik, Paige Murphy, Daniel B Harmon, Tom Charpentier, Benjamin J Doranz, Joseph B Rucker

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Mentions

68
Peak: 4 in Jan 2023
across 3 sources since Dec 2022

Extended reach

37,620
potential audience

Total likes

16

Video views

500

Mentions per month

Dec 2022 – Oct 2024

Where it's discussed

  • News60 articles
  • X / Twitter6 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a moderate level of interest and agreement, exemplified by comments referencing previous related papers and emphasizing the relevance of the study's findings, such as concerns about epitope specificity and its therapeutic potential. The tone indicates respect for the research's significance, but the engagement remains relatively surface-level.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, especially the concern about cross-reactivity with Claudin 9, indicating general approval and recognition of the study's significance.

InterestModerate interest

Participants show moderate curiosity, with some referencing previous related research and urging others to read the full article, but few delve deeply into methodological details.

EngagementNeutral engagement

The interactions are somewhat superficial, mainly repeated affirmations or references to related work, rather than in-depth conversations or critiques.

ImpactModerate impact

The discussions highlight the potential implications for targeted cancer therapies, suggesting the research could influence future treatment strategies, but without detailed debate.

Abstract in brief

  • The study focuses on developing highly specific monoclonal antibodies (MAbs) against the cancer-associated protein Claudin 6 (CLDN6), which is similar to the closely related protein CLDN9, making targeted therapy challenging.
  • Researchers successfully isolated rare MAbs that bind tightly to CLDN6 with minimal cross-reactivity to CLDN9 by identifying unique epitopes at the amino acid level, particularly a single contact point involving the carbon atom on CLDN6 residue Q156.
  • The structural analysis revealed that these MAbs distinguish CLDN6 from CLDN9 through steric hindrance at this key atomic contact, offering a promising approach for more precise cancer therapies targeting CLDN6.]

Top posts

Most liked on X and Bluesky
Anirban Maitra
@Aiims1742 · X

Btw, the concern about epitope cross reactivity with the widely expressed Claudin 9 mentioned in the article is real. There was an @iScience_CP paper last year on developing highly specific anti-Claudin 6 antibodies that do not cross react. https://t.co/EEmS0AHBLN

Jan 18, 2023 · 4 likes · 2 shares · 31,485 followers View post →
Context Therapeutics
@Context_Tx · X

Read the full research article here. $CNTX https://t.co/cUb9V9ciCU

Jan 5, 2023 · 1 like · 478 followers View post →
د.عبدالله علي الشرم
@dralsharm · X

RT @Aiims1742: Btw, the concern about epitope cross reactivity with the widely expressed Claudin 9 mentioned in the article is real. There…

Jan 19, 2023 · 2 shares · 3,957 followers View post →
memprotbiophys
@memprot_biophys · X

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point https://t.co/SAyjNm2EGC https://t.co/cMtDIwoipX

Dec 12, 2022 · 674 followers View post →
Vladislav Sergeev
@DrVladSergeev · X

RT @Aiims1742: Btw, the concern about epitope cross reactivity with the widely expressed Claudin 9 mentioned in the article is real. There…

Jan 18, 2023 · 2 shares · 285 followers View post →
Kursad Turksen
@kursadturksen · X

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point https://t.co/O3vY3ObMgQ

Oct 13, 2024 · 230 followers View post →

All mentions

Kursad Turksen
@kursadturksen · X

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point https://t.co/O3vY3ObMgQ

Oct 13, 2024 · 230 followers View post →
د.عبدالله علي الشرم
@dralsharm · X

RT @Aiims1742: Btw, the concern about epitope cross reactivity with the widely expressed Claudin 9 mentioned in the article is real. There…

Jan 19, 2023 · 2 shares · 3,957 followers View post →
Vladislav Sergeev
@DrVladSergeev · X

RT @Aiims1742: Btw, the concern about epitope cross reactivity with the widely expressed Claudin 9 mentioned in the article is real. There…

Jan 18, 2023 · 2 shares · 285 followers View post →
Anirban Maitra
@Aiims1742 · X

Btw, the concern about epitope cross reactivity with the widely expressed Claudin 9 mentioned in the article is real. There was an @iScience_CP paper last year on developing highly specific anti-Claudin 6 antibodies that do not cross react. https://t.co/EEmS0AHBLN

Jan 18, 2023 · 4 likes · 2 shares · 31,485 followers View post →
Context Therapeutics
@Context_Tx · X

Read the full research article here. $CNTX https://t.co/cUb9V9ciCU

Jan 5, 2023 · 1 like · 478 followers View post →
memprotbiophys
@memprot_biophys · X

Antibody specificity against highly conserved membrane protein Claudin 6 driven by single atomic contact point https://t.co/SAyjNm2EGC https://t.co/cMtDIwoipX

Dec 12, 2022 · 674 followers View post →