PubHawk
JAMA December 2022 PMID 36508210

Target Trial Emulation: A Framework for Causal Inference From Observational Data.

Miguel A Hernán, Wei Wang, David E Leaf

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Mentions

159
Peak: 80 in Dec 2022
across 5 sources since Dec 2022

Extended reach

1,510,089
potential audience

Total likes

401

Video views

84

Mentions per month

Dec 2022 – Jun 2025

Where it's discussed

  • X / Twitter148 posts
  • News4 articles
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

In the collected discussions, users mentioned specific applications and limitations of the target trial emulation framework, such as comparing it to randomized controlled trials and discussing its role in improving research quality. Sentiments expressed include confusion over why emulation should be preferred over direct randomization, as seen in the remarks about 'pseudo randomization’ being problematic, which reflects uncertainty and a critical tone toward the framework’s implementation.

AgreementNeither agree nor disagree

The discussions reflect a mix of support and skepticism regarding the emulation of randomized trials, showing that users have divided opinions about the framework's application.

InterestModerate interest

While many participants express curiosity about the publication, some show confusion or skepticism, indicating a moderate interest in the topic.

EngagementModerate engagement

A number of posts reference research methods and implications, suggesting that users are engaging at a decent level, although some remain dismissive.

ImpactModerate impact

There's recognition of the framework's potential influence on observational research, but varying views on its effectiveness limit the overall perception of its impact.

Abstract in brief

  • It introduces a framework called "target trial emulation" that aims to replicate the conditions of a randomized controlled trial using observational data.
  • The approach helps to draw causal inferences by identifying and addressing biases that can occur in non-randomized settings.
  • By structuring the analysis like a clinical trial, researchers can make stronger, more reliable conclusions about treatment effects.
Read the full abstract

Top posts

Most liked on X and Bluesky
JAMA
@JAMA_current · X

Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Observational Data" with JAMA Statistical Editor Roger J. Lewis. https://t.co/cDgr23toHt

May 3, 2024 · 126 likes · 46 shares · 488,717 followers View post →
KRSK
@koro485 · X

JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 94 likes · 18 shares · 19,711 followers View post →
JAMA
@JAMA_current · X

Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the advantages of an RCT, points out the limitations of the method, and provides an example of its use. @DavidLeaf9 https://t.co/pJqp4uOkDA

Dec 30, 2022 · 70 likes · 27 shares · 488,717 followers View post →
David Harrison
@DavidHarrison80 · X

.@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 https://t.co/kOVZVwH55f

Jun 15, 2023 · 35 likes · 6 shares · 445 followers View post →
M. Bolton
@5_utr · X

I don’t understand why anybody would want to try to “emulate” a randomized trial rather than just do a randomize. “Pseudo randomization” etc leads to nowhere good @RWJE_BA https://t.co/bH1HoLdfZ8

Feb 12, 2025 · 12 likes · 5 shares · 2,399 followers View post →
コクランジャパン
@CochraneJapan · X

JAMAよりtarget trial emulationのガイドが出ています。 https://t.co/L9R3u29PmX

Dec 14, 2022 · 11 likes · 12,356 followers View post →

All mentions

DrShahidaDin
@ShahidaDin1 · X

RT @pash22: Target Trial Emulation: A Framework for Causal Inference From Observational Data via @_MiguelHernan et al https://t.co/4AauZ60x…

Feb 24, 2025 · 1 share · 2,049 followers View post →
Ash Paul
@pash22 · X

Target Trial Emulation: A Framework for Causal Inference From Observational Data via @_MiguelHernan et al https://t.co/4AauZ60xeP https://t.co/JsWaSAij7U

Feb 24, 2025 · 5 likes · 1 share · 32,289 followers View post →
Yu Yang Soon
@yysoon01 · X

RT @5_utr: I don’t understand why anybody would want to try to “emulate” a randomized trial rather than just do a randomize. “Pseudo random…

Feb 13, 2025 · 5 shares · 314 followers View post →
Boussageon Rémy
@BoussageonR · X

RT @5_utr: I don’t understand why anybody would want to try to “emulate” a randomized trial rather than just do a randomize. “Pseudo random…

Feb 13, 2025 · 5 shares · 624 followers View post →
Roger Borràs
@RWJE_BA · X

RT @5_utr: I don’t understand why anybody would want to try to “emulate” a randomized trial rather than just do a randomize. “Pseudo random…

Feb 12, 2025 · 5 shares · 968 followers View post →
M. Bolton
@5_utr · X

I don’t understand why anybody would want to try to “emulate” a randomized trial rather than just do a randomize. “Pseudo randomization” etc leads to nowhere good @RWJE_BA https://t.co/bH1HoLdfZ8

Feb 12, 2025 · 12 likes · 5 shares · 2,399 followers View post →
Kenar Jhaveri
@kdjhaveri · X

7) The investigators used a rigorous target trial emulation framework to infer a causal relationship between glucarpidase receipt and kidney recovery. #TargetTrialEmulation https://t.co/aCLDoTJoIJ https://t.co/iI5cCmdn8P

Jan 10, 2025 · 2 likes · 11,721 followers View post →
Jordy Cohen, MD, MSCE
@jordy_bc · X

@hswapnil @FuEdouard @kidney_boy @seanluomdphd The approach addresses major limitations of propensity score matching and raises observational research to a higher bar. Dr. Fu's review

Sep 4, 2024 · 3 likes · 2,946 followers View post →
Drive On NKB
@DriveOnNKB · X

病院薬剤師の皆さん、ホントさ、『薬剤師はRCTできないんだからさ』とかひねくれてないで、宝の山の認識持ちましょう！ Target Trial Emulation for Causal Inference From Observational Data https://t.co/LBwnpgQBTH

Jun 29, 2024 · 130 followers View post →
Ram Bajpai
@RamBajpai16 · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 20, 2024 · 46 shares · 212 followers View post →
R. Mellado-Artigas
@eRReeMe1 · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 19, 2024 · 46 shares · 149 followers View post →
Francisco Escobar A
@franescobar_a · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 19, 2024 · 46 shares · 54 followers View post →
Miquel Porta
@miquelporta · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 19, 2024 · 46 shares · 4,250 followers View post →
うらけん 耳鼻科×疫学勉強中
@iPsTXEzOAhbmkoK · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 291 followers View post →
rafael mello galliez
@RafaelGalliez · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 149 followers View post →
@docbio.bsky.social
@DocBio1509 · X

https://t.co/01I7LQQaAr

May 18, 2024 · 1 like · 459 followers View post →
Munya Dimairo
@mdimairo · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 2,533 followers View post →
Yonemoto N
@nyonenyone · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 1,272 followers View post →
trainspotting_54321
@trainspotting_5 · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 72 followers View post →
Justin Losciale, PT, DPT
@JayLos18 · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 674 followers View post →
Garrett Bullock PT, DPT, DPhil
@DrGSBullock · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 871 followers View post →
Jesus Rodriguez Baño
@jesusrbano · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 7,882 followers View post →
Miquel Bennasar Veny
@miquelbennasar · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 1,384 followers View post →
Klau Prez |
@hospitalismos · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 337 followers View post →
Jacob Jameson
@JacobCJameson · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 838 followers View post →
Jorge Pacheco Jara
@jorge_pacheco · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 18, 2024 · 46 shares · 8,328 followers View post →
kokako
@kokako65541706 · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 4, 2024 · 46 shares · 6 followers View post →
Jordan Vajda MD MPH MA MDiv
@jordan_vajda · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 4, 2024 · 46 shares · 481 followers View post →
Ana Rivera Almaraz
@AlmarazRivera · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 4, 2024 · 46 shares · 106 followers View post →
Bruno Besen
@BesenBruno · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 1,984 followers View post →
alter-eggo
@altereggo · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 1,156 followers View post →
Mirza Khan
@mirzakhan_ · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 316 followers View post →
M.A
@traumareporter · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 130 followers View post →
Shashank Sinha, MD, MSc, FACC, FAHA, FHFSA
@ShashankSinhaMD · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 4,774 followers View post →
Ashish
@trivediaa · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 713 followers View post →
Martin Correa
@martinrafco · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 232 followers View post →
Aghiles Hamroun
@AghilesHamroun · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 724 followers View post →
Joel Moskowitz
@berkeleyprc · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 2,906 followers View post →
Peter Louis, M.D., J.D., FCAP⚕️
@MDJDPathology · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 843 followers View post →
Nana C
@Nana_UbonphanC · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 26 followers View post →
Pavlos Bobos
@pavlosbob · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 1,457 followers View post →
Anand Narayan, MD, PhD (he/him)
@AnandKNarayan · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 2,169 followers View post →
Pedro Ochoa-Allemant
@OchoaAllemantMD · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 938 followers View post →
Daniele Orso
@Orso_dan · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 357 followers View post →
Ruben Hernaez
@ruben_hernaez · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 2,520 followers View post →
Melissa Flores
@flores_socsci · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 350 followers View post →
Carlos KH Wong
@CarlosWongHKU · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 495 followers View post →
Mehdi Maanaoui
@MaanaouiMehdi · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 1,003 followers View post →
Deirdre Tobias, ScD
@deirdre_tobias · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 9,611 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 573 followers View post →
Dr Gemma Lewis
@GemmaLewis13 · X

RT @JAMA_current: Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Obse…

May 3, 2024 · 46 shares · 1,765 followers View post →
JAMA
@JAMA_current · X

Professor @_MiguelHernan of @HarvardChanSPH discusses "Target Trial Emulation: A Framework for Causal Inference From Observational Data" with JAMA Statistical Editor Roger J. Lewis. https://t.co/cDgr23toHt

May 3, 2024 · 126 likes · 46 shares · 488,717 followers View post →
うーまく13歳
@pingue7 · X

来週TTEのお話拝聴できるので興味深く&楽しみです https://t.co/mSNKwB3Mly https://t.co/mSNKwB3Mly

Dec 12, 2023 · 1,784 followers View post →
Robert W. Yeh
@rwyeh · X

@djc795 @ma_hussainMD @PatrickHeindel @BrighamVascular @BrighamSurgery @CSPH_BWH @PVDCouncil @AbenaSamp @JJFitzgibbon @EricSecemskyMD @Dr_Alomran @ialmaghlouth @secemsky Should be "target trial emulation" https://t.co/5xOYtZAu5i

Nov 12, 2023 · 3 likes · 18,700 followers View post →
古谷直弘
@Na_furuya · X

Target Trial Emulation https://t.co/a4paffmThT フルテキストで取れるかな。帰ったら確認する。

Sep 26, 2023 · 1,633 followers View post →
Jan Hansel
@VirtueOfNothing · X

@doctimcook Improving rheumatoid arthritis comparative effectiveness research through causal inference principles: SR using a target trial emulation framework https://t.co/QzSCQ7BQy7 Target Trial Emulation: A Framework for Causal Inference From Observational Data https://t.co/I7Tr8RuTra https://t.co/0Qk30SYA5h

Sep 22, 2023 · 4,313 followers View post →
Luisa N. Borrell @lborrell.bsky.social
@LuisaBorrell · X

@CommDentOralEpi How about the target trial emulation? Check this out from @_MiguelHernan et al https://t.co/3CWmFP5qmz

Jun 19, 2023 · 1,250 followers View post →
Peter Bower
@Bowercpcman · X

RT @DavidHarrison80: .@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 h…

Jun 16, 2023 · 6 shares · 957 followers View post →
Dale Needham, MD, PhD
@DrDaleNeedham · X

RT @DavidHarrison80: .@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 h…

Jun 15, 2023 · 6 shares · 11,585 followers View post →
Jonny Wilkinson
@Wilkinsonjonny · X

RT @DavidHarrison80: .@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 h…

Jun 15, 2023 · 6 shares · 13,542 followers View post →
Eddy Fan
@efan75 · X

RT @DavidHarrison80: .@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 h…

Jun 15, 2023 · 6 shares · 2,479 followers View post →
Michelle Kho, PT, PhD
@khome · X

RT @DavidHarrison80: .@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 h…

Jun 15, 2023 · 6 shares · 1,688 followers View post →
David Harrison
@DavidHarrison80 · X

.@ADAlthousePhD introduces the concept of target trial emulation for causal inference from observational data #CCR23 https://t.co/kOVZVwH55f

Jun 15, 2023 · 35 likes · 6 shares · 445 followers View post →
Chao Wang
@excel_wang · X

@adamjkucharski No doubt we can evaluate X vs Y in a RCT. If this makes sense for RCT, I cannot think why it would not make sense for observational study, though OS is more complicated in that we need to define "time zero" more carefully. https://t.co/bIj6c3aUgm

Jun 9, 2023 · 1,564 followers View post →
Pavlos Msaouel
@PavlosMsaouel · X

RT @Lester_Domes: @yudapearl @AnjaLeist @rohitpojha @EpiEllie @_MiguelHernan @casualinfer I believe the problems TTE addresses as well as T…

Feb 11, 2023 · 1 share · 3,547 followers View post →
Sander Greenland
@Lester_Domes · X

@yudapearl @AnjaLeist @rohitpojha @EpiEllie @_MiguelHernan @casualinfer I believe the problems TTE addresses as well as TTE limitations are laid out succinctly in "Target Trial Emulation: A Framework for Causal Inference From Observational Data", https://t.co/S2WQOJK5Fe

Feb 9, 2023 · 4 likes · 1 share · 3,912 followers View post →
kitmr
@sttstcs · X

Target Trial Emulation: A Framework for Causal Inference From Observational Data | Research, Methods, Statistics | JAMA | JAMA Network https://t.co/TnbU7FvZ4Z

Jan 12, 2023 · 278 followers View post →
ModernTimes
@lstmpsmdrns · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Jan 1, 2023 · 49 shares · 644 followers View post →
Robert Gaiser, MD
@RobertGaiser1 · X

New Years Resolution - improve understanding of #statistics -Target Trial Emulation: A Framework for Causal Inference From Observational Data | Research, Methods, Statistics | JAMA | JAMA Network https://t.co/4XYytjyT2z

Dec 31, 2022 · 3 likes · 1,455 followers View post →
Ana Calber
@amcalber · X

RT @joserrapa: @quequesierra @boticariors @PabloGVasco @jesusrbano @PROAmacarena @MariadelMarTom @Luis_Corral_Gud @micromunidad @ligero999…

Dec 31, 2022 · 2 shares · 2,271 followers View post →
Dr. Antonio Gutiérrez
@boticariors · X

RT @joserrapa: @quequesierra @boticariors @PabloGVasco @jesusrbano @PROAmacarena @MariadelMarTom @Luis_Corral_Gud @micromunidad @ligero999…

Dec 31, 2022 · 2 shares · 11,169 followers View post →
rafael mello galliez
@RafaelGalliez · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 149 followers View post →
Dr. Lucia Petito
@lucia_petito · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 649 followers View post →
TH@疫学
@pon144 · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 443 followers View post →
Dale Needham, MD, PhD
@DrDaleNeedham · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 11,585 followers View post →
Jordan Vajda MD MPH MA MDiv
@jordan_vajda · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 481 followers View post →
Eddy Fan
@efan75 · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 2,479 followers View post →
Mikkel GB
@mgybel · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 277 followers View post →
Anest_ArrietaO
@MariArrietaO1 · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 592 followers View post →
Kirsten Bibbins-Domingo
@KBibbinsDomingo · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 13,405 followers View post →
Diego
@dlarcaster · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 90 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @JAMA_current: Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the a…

Dec 30, 2022 · 27 shares · 1,824 followers View post →
JAMA
@JAMA_current · X

Guide to Statistics and Methods: the use of target trial emulation to design an observational study so it preserves the advantages of an RCT, points out the limitations of the method, and provides an example of its use. @DavidLeaf9 https://t.co/pJqp4uOkDA

Dec 30, 2022 · 70 likes · 27 shares · 488,717 followers View post →
José Ramón Paño
@joserrapa · X

@quequesierra @boticariors @PabloGVasco @jesusrbano @PROAmacarena @MariadelMarTom @Luis_Corral_Gud @micromunidad @ligero999 @drmiguelmarcos @joancmarch Covid también ha ayudado a perfeccionar el diseño de estudios observacionales para tratar de conocer el efecto de fármacos o intervenciones. Porque no siempre es posible disponer de información derivada de un ensayo clínico. https://t.co/u7eCdea8HF

Dec 30, 2022 · 2 likes · 2 shares · 3,722 followers View post →
HN
@nagano_1123 · X

今日のJAMAよりTarget Trial Emulation. 色々とポイントはあるのだろうが、追跡開始地点を治療開始時じゃなく適格基準を満たしたタイミングとするのが重要なのだろうか、Immortal time biasなどを避けるために。 https://t.co/WIvwDg9Lk9

Dec 28, 2022 · 5 likes · 5,335 followers View post →
Probably Approximately Correct
@PAClearning · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 27, 2022 · 49 shares · 12,034 followers View post →
Kuan Liu 刘宽
@KuanLiu2 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 16, 2022 · 49 shares · 543 followers View post →
Guanbo Wang
@Guanbo17 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 15, 2022 · 49 shares · 141 followers View post →
adeyu/チョコミン党
@th_adieu · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 14, 2022 · 18 shares · 1,886 followers View post →
白石 淳, 救急医 / Shiraishi Atsushi, MD, PhD
@shiraishia_md · X

愛読しているJAMA Guide to Statistics and Methods より。これも必読。Target Trial Emulation は近年非常に重要さを増している臨床研究デザインの概念で、要するに観察研究のデータからランダム化比較試験を模することである。 https://t.co/Qe8GlEbcd6 via @JAMA_current part of @JAMANetwork

Dec 14, 2022 · 10 likes · 2 shares · 21,560 followers View post →
くすり星人
@seijin_o · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 14, 2022 · 18 shares · 86 followers View post →
Satoru Mitsuboshi
@3stars67664378 · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 14, 2022 · 18 shares · 1,786 followers View post →
Chengsheng Ju
@ChengshengJ · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 14, 2022 · 49 shares · 119 followers View post →
コクランジャパン
@CochraneJapan · X

JAMAよりtarget trial emulationのガイドが出ています。 https://t.co/L9R3u29PmX

Dec 14, 2022 · 11 likes · 12,356 followers View post →
Georg Heinze
@Georg__Heinze · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 14, 2022 · 49 shares · 1,097 followers View post →
epibot
@epi_twit · X

RT @LungIsLong: Target Trial Emulation A Framework for #Causal Inference From Observational Data #epitwitter https://t.co/t5ZSIy0Qii

Dec 14, 2022 · 1 share · 3,131 followers View post →
Ernesto Juárez
@LungIsLong · X

Target Trial Emulation A Framework for #Causal Inference From Observational Data #epitwitter https://t.co/t5ZSIy0Qii

Dec 14, 2022 · 1 share · 1,100 followers View post →
Yuki Fujii, M.D., Ph.D.,
@yukifujii61 · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 215 followers View post →
Simon Pollett
@simon_pollett · X

RT @davidantibiotic: Would be good to see this as the new standard for observational studies on comparative antibiotic effectiveness - Tar…

Dec 13, 2022 · 2 shares · 252 followers View post →
Lars-Johan Valaas
@arsjoha · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 46 followers View post →
Sean Ong
@seanongwx · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 599 followers View post →
Patrick Heindel, MD, MPH
@PatrickHeindel · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 486 followers View post →
Mar García #NiUnaMás
@MarthaItzelGar6 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 262 followers View post →
Tat-Thang Vo
@TatThangVo1 · X

RT @triadsou: JAMA Guide to Statistics and Methods Target Trial Emulation: A Framework for Causal Inference From Observational Data. Migue…

Dec 13, 2022 · 2 shares · 238 followers View post →
Johann Castañeda PharmD
@Nocebo88 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 366 followers View post →
Chelsea Messinger, MD, PhD
@chelsmessinger · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 708 followers View post →
Akira Murakami
@mrkm_a · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 2,709 followers View post →
@thevelvetmeow.bsky.social
@thevelvetmeow · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 783 followers View post →
Antonio Bayo
@AntonioBayo3 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 23 followers View post →
Lux Li
@Lux_Li_ · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 117 followers View post →
Anvesh Narimiti, MD MPH
@ANarimiti · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 204 followers View post →
NeuroPsychTube
@NeuropsychTube · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 16 followers View post →
Deshire Alpizar-Rodriguez
@deshire_alpizar · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 813 followers View post →
Dr. Rubén López
@rlopezbu · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 3,396 followers View post →
Justin Losciale, PT, DPT
@JayLos18 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 674 followers View post →
S. Reza Jafarzadeh
@srjafarz · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 107 followers View post →
takehiko-i-hayashi
@takehikohayashi · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 4,922 followers View post →
krk
@rkymch · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 110 followers View post →
Masa
@asas_mimi · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 4,343 followers View post →
Trung Nguyen
@drtrungnguyen · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,392 followers View post →
Thomas Meinel
@TotoMynell · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,611 followers View post →
François Montastruc, MD, PhD
@montastrucf · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,071 followers View post →
blckrvr
@blckrvr1 · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 806 followers View post →
くねちゃん（まじめ）
@fuwakune · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 294 followers View post →
Fuyuki Owa
@fuyuki_owa · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 636 followers View post →
Masako
@Masako_Araki1 · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 1,125 followers View post →
Shunsuke Oyamada
@oyashun1229 · X

RT @koro485: JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 18 shares · 778 followers View post →
KRSK
@koro485 · X

JAMAよりTarget trial emulationの簡潔な紹介。観察データから理想的なRCTを模倣しましょうというお話。 https://t.co/F3ioG3DiRz

Dec 13, 2022 · 94 likes · 18 shares · 19,711 followers View post →
Julio C. Zuniga-Moya
@JulioCZuniga1 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,503 followers View post →
Gabriel Leung
@gmleunghku · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 18,161 followers View post →
Dr Ellie Murray, ScD
@EpiEllie · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 123,155 followers View post →
Tesfahun C. Eshetie
@tesfuc · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 229 followers View post →
Eddy Fan
@efan75 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 2,479 followers View post →
Gonzalo Mena
@mena_gonzalo · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 3,560 followers View post →
Rubén Martínez
@EldarSilver · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,881 followers View post →
Paul Truché, MD, MPH
@ptrucheMD · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 3,028 followers View post →
José A. Calvache
@jacalvache · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 806 followers View post →
Leonardo D'Ambrosi
@leodambrosi · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 217 followers View post →
Paula C. Ramírez
@RmPaulac · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 143 followers View post →
Masako
@Masako_Araki1 · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,125 followers View post →
Shibata Masashi@GP×EBM
@EbmShibanyan · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 1,690 followers View post →
Triad sou.
@triadsou · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 2,220 followers View post →
Ignacio Retamal
@nachoretamal · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 908 followers View post →
William García
@wrgarciag · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 519 followers View post →
Dale Needham, MD, PhD
@DrDaleNeedham · X

RT @_MiguelHernan: 1/ Our summary of #TargetTrial emulation is out. We illustrate it with another observational success: A survival benef…

Dec 13, 2022 · 49 shares · 11,585 followers View post →
nihilistic.yue
@nihil_inside · X

RT @triadsou: JAMA Guide to Statistics and Methods Target Trial Emulation: A Framework for Causal Inference From Observational Data. Migue…

Dec 13, 2022 · 2 shares · 185 followers View post →
Triad sou.
@triadsou · X

JAMA Guide to Statistics and Methods Target Trial Emulation: A Framework for Causal Inference From Observational Data. Miguel A. Hernán, Wei Wang, David E. Leaf. JAMA. https://t.co/QXd5NyLl7K

Dec 13, 2022 · 10 likes · 2 shares · 2,220 followers View post →
renalRCTs
@renalRCTs · X

Target Trial Emulation: A Framework for Causal Inference From Observational Data https://t.co/xa7pTp7XVy https://t.co/E52C0gnRNG

Dec 12, 2022 · 39 followers View post →