Nat Commun December 2022 PMID 36513655

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations.

Mina Farag, Samuel R Cohen, Wade M Borcherds, Anne Bremer, Tanja Mittag, Rohit V Pappu

Mentions

16
Peak: 8 in Dec 2022
across 4 sources since Dec 2022

Extended reach

22,386
potential audience

Total likes

27

Video views

27

Mentions per month

Dec 2022 – Aug 2023

Where it's discussed

  • X / Twitter8 posts
  • News4 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions reflect a positive reception, with mentions like 'Condensates form small-world networks' and statements such as 'these structures influence biochemical functions,' demonstrating appreciation and curiosity. The tone suggests respect for the research's significance but stops short of extensive debate or critical analysis.

AgreementStrong agreement

All discussions recognize and affirm the main findings of the publication, indicating strong overall support.

InterestModerate interest

Participants show moderate curiosity, often referencing the significance of the small-world structures and biological relevance.

EngagementModerate engagement

Comments include some elaboration on the mechanisms and implications, but lack deep technical critique or alternative viewpoints.

ImpactModerate impact

The discussions suggest that the findings are considered meaningful within the scientific community, though not universally deemed revolutionary.

Abstract in brief

  • Condensates formed by prion-like low complexity domains (PLCDs) have small-world network structures with interfaces shaped by expanded conformations, which influence their biochemical functions.
  • The formation of these condensates involves coupled phase transitions, such as phase separation and percolation, driven by multivalent associative interactions mediated by cohesive motifs called stickers and the spacers that regulate their cooperativity.
  • Simulations show that within condensates, PLCD molecules are organized into reversible networks with small-world topology, displaying spatial inhomogeneity, especially at interfaces, which primes these structures for biological activity.

Top posts

Most liked on X and Bluesky
ShorterLab
@ShorterLab · X

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations: https://t.co/BELaY8RnYE

Dec 13, 2022 · 27 likes · 8 shares · 12,024 followers View post →
New papers in Network Science
@networkspapers · X

Nat. Commun.: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations https://t.co/noF2LY9wcO

Dec 20, 2022 · 4,727 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 3,217 followers View post →
Sarah H. Shahmoradian
@ShahmoraLab · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 1,410 followers View post →
Sandeep Kumar Rai
@Sandeep61011718 · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 580 followers View post →
Jaehoon Jung
@JungLab_SKKU · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 14, 2022 · 8 shares · 176 followers View post →

All mentions

New papers in Network Science
@networkspapers · X

Nat. Commun.: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations https://t.co/noF2LY9wcO

Dec 20, 2022 · 4,727 followers View post →
Eunhee Koh
@kohprotein · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 19, 2022 · 8 shares · 15 followers View post →
Jaehoon Jung
@JungLab_SKKU · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 14, 2022 · 8 shares · 176 followers View post →
Sarah H. Shahmoradian
@ShahmoraLab · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 1,410 followers View post →
成田
@nrinsushi · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 98 followers View post →
Sandeep Kumar Rai
@Sandeep61011718 · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 580 followers View post →
Shorter Lab Members
@ShorterLabGroup · X

RT @ShorterLab: Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expan…

Dec 13, 2022 · 8 shares · 3,217 followers View post →
ShorterLab
@ShorterLab · X

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations: https://t.co/BELaY8RnYE

Dec 13, 2022 · 27 likes · 8 shares · 12,024 followers View post →