This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on this topic: https://t.co/0JppgprxXa https://t.co/Ht1QJJhscO Basic neurobiology: longer exposure, greater adaptation, greater withdrawal on stopping. https://t.co/YzHtZd6Bum
Estimating Risk of Antidepressant Withdrawal from a Review of Published Data.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Dec 2022 – Sep 2025Where it's discussed
-
X / Twitter114 posts
-
News28 articles
-
Blogs5 articles
-
YouTube3 videos
AI synopsis
What people are saying
Several posts reference the correlation between the length of time on medication and the severity of withdrawal effects, with users stating things like, 'Length of time on medication correlates with withdrawal effects.' This indicates a clear understanding of the article’s main arguments. The tone is often assertive and collaborative, employing phrases like 'here's some research to consider,' which showcases engagement and a desire to share knowledge within the community.
The majority of discussions indicate a general consensus supporting the article's findings about the correlation between the duration of antidepressant use and withdrawal effects.
The discussions reflect a high level of curiosity and relevance regarding antidepressant withdrawal issues, indicating strong engagement with the topic.
Many users delve into the details of the research, referencing specific studies and evidence, and actively participate in discussions about the implications of the findings.
Participants express a belief that the findings of the publication will have significant implications for clinical practices and patients' experiences.
Abstract in brief
- The brain can physically adapt to antidepressants, leading to withdrawal symptoms upon stopping use, which is distinct from addiction.
- Longer usage, higher doses, and specific types of antidepressants increase the likelihood and severity of these withdrawal effects.
- Current research is limited, highlighting the need for more studies to better understand and predict antidepressant withdrawal risks and help inform tapering strategies for patients.
Top posts
Most liked on X and BlueskyIn human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (mean 29 months) after antidepressants have been ceased. https://t.co/AUbIfqpsk7 https://t.co/9yCfjhvZfG
Other studies have shown that duration of use has a strong effect on risk of withdrawal and severity of those withdrawal effects. See image where risk of withdrawal (top line) and those who report mod or severe withdrawal tracks with duration of use https://t.co/0Jppgps5MI 5/n https://t.co/QAs9ofFYOi
We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after stopping in this paper: https://t.co/AUbIfqpsk7 . Excerpts attached https://t.co/LK0eBrJecq https://t.co/6SuCPBoIqe
withdrawal effects (similarly to the results of this meta-analysis), with 19.2% reporting moderate or severe withdrawal effects (Figure 3 in https://t.co/0JppgprxXa ); 6/n
Despite Jauhar, tryptophan depletion effects in patients in the 2007 review are inconsistent, numbers small, heterogeneity significant, and results likely influenced by current or prior use of meds since antidepressant effects can persist https://t.co/39rHwl30Uh 14/28
All mentions
Understanding Antidepressant Withdrawal Risks and Effects
This video discusses critical insights into antidepressant withdrawal, including how the brain adapts to these medications. It emphasizes the importance of understanding withdrawal symptoms, the factors that influence…
Understanding Psychiatric Drug Withdrawal Risks and Strategies
In this insightful interview, clinician Anders Sørensen discusses his research on psychiatric drug withdrawal. He explores how the brain adapts to antidepressants, leading to withdrawal symptoms, and emphasizes the…
Effective Strategies for Safe Medication Tapering
In today's video, we discuss our top tips for safely tapering psychotropic medications. The brain can adapt physically to antidepressants, leading to withdrawal symptoms when discontinuing use. Understanding these risks…
@Oxfordite @wendyburn I shared three scientific papers with you. Here’s another
@Pat_McDermott17 In some cases yes: https://t.co/bMmBtsRiaO
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: @sameerjauhar This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: @sameerjauhar This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: @sameerjauhar This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all…
RT @markhoro: This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on th…
RT @markhoro: @sameerjauhar This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all…
@sameerjauhar This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on this topic: https://t.co/0JppgprxXa https://t.co/Ht1QJJhscO Basic neurobiology: longer exposure, greater adaptation, greater withdrawal on stopping.
This is false. @JDaviesPhD is correct. Length of time on medication correlates with withdrawal effects. In all analyses on this topic: https://t.co/0JppgprxXa https://t.co/Ht1QJJhscO Basic neurobiology: longer exposure, greater adaptation, greater withdrawal on stopping. https://t.co/YzHtZd6Bum
@RecoveryDoctor Sarcasm works better when delivered with an accurate barb. No conflation: the biological gradient is much stronger with duration than dose. https://t.co/AUbIfqq09F https://t.co/TNJ9wSUXZl
RT @cwestonclark: @allyofthebrave @venetiamenzies @thetimes As far as I know, all classes of antidepressant have the potential to cause wit…
@allyofthebrave @venetiamenzies @thetimes As far as I know, all classes of antidepressant have the potential to cause withdrawal. I'm aware that mirtazipine and paroxetine are among the worst offenders. This article has some stats about different types of antidepressant. https://t.co/FavFBlZi3v
@NiniBela1 @samziz Some people are allergic to peanut butter and some aren’t. Genetics has evidence that some metabolize these drugs easier than others do. Your observations aren’t all of them. Here’s some research to consider: https://t.co/bMmBtsRiaO feel free to examine the citations as well.
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
@RobertKennedyJr What I would say about antidepressants (& benzos) is that they need to be withdrawn much slower than conventional wisdom states. Although more evidence is mounting, start with the below: https://t.co/yZg4DHAS07
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
RT @markhoro: @wendyburn @sanilrege We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hor…
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
RT @markhoro: We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after st…
We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after stopping in this paper: https://t.co/AUbIfqpsk7 . Excerpts attached https://t.co/LK0eBrJecq https://t.co/6SuCPBoIqe
@wendyburn @sanilrege We outlined the animal and human evidence for residual effects of antidepressants on the brain (and hormonal system) after stopping in this paper: https://t.co/AUbIfqpsk7 . Excerpts attached https://t.co/JQCJuRSqSv
@RecoveryDoctor @EikoFried Here's a survey of patients reporting withdrawal effects (and their severity) which shows a clear biological gradient with length of use that increases after >6 month use https://t.co/AUbIfqpsk7 https://t.co/239zCV1Ami
@Jim52135 https://t.co/AUbIfqq09F
withdrawal effects (similarly to the results of this meta-analysis), with 19.2% reporting moderate or severe withdrawal effects (Figure 3 in https://t.co/0JppgprxXa ); 6/n
Other studies have shown that duration of use has a strong effect on risk of withdrawal and severity of those withdrawal effects. See image where risk of withdrawal (top line) and those who report mod or severe withdrawal tracks with duration of use https://t.co/0Jppgps5MI 5/n https://t.co/QAs9ofFYOi
@ScholerinED @gmshpfm @EM_RESUS whats up with the refs? I did not say it doesn’t make people sleep https://t.co/GkALY8veoZ
@DBDouble @joannamoncrieff @ReadReadj There are some recognised risks, including duration of use, as we put in the resource but still not a perfect science because little research. Summarised here: https://t.co/AUbIfqpsk7
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
RT @markhoro: In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (…
In human PET studies reduced sensitivity of 5HT1A receptors are found in 38 out of 40 brain regions looked at up to 6 years (mean 29 months) after antidepressants have been ceased. https://t.co/AUbIfqpsk7 https://t.co/9yCfjhvZfG
@Altostrata @AshDSpencer @stopharmingus @shvogt @pssd_awareness @ChrisGovernale @DrMcFillin @PssdWarrior @pssd_victim @jill_d35 @benzosarebad @joannamoncrieff @recover2renew @Inamadworld1 @markhoro Your work: from RCTs risk skyrockets after > 2-3 months, from surveys even more after > 1 year (but sparse data). These are short timescales for standard treatment. My point: neglected transduction explanation is much more scary, but more informative. https://t.co/YJXVHBQPur
RT @markhoro: @DBDouble @shvogt @JDaviesPhD The brain changes in antidepressant use found in humans and animals is summarised here https://…
RT @joannamoncrieff: Despite Jauhar, tryptophan depletion effects in patients in the 2007 review are inconsistent, numbers small, heterogen…
RT @joannamoncrieff: Despite Jauhar, tryptophan depletion effects in patients in the 2007 review are inconsistent, numbers small, heterogen…
Despite Jauhar, tryptophan depletion effects in patients in the 2007 review are inconsistent, numbers small, heterogeneity significant, and results likely influenced by current or prior use of meds since antidepressant effects can persist https://t.co/39rHwl30Uh 14/28
RT @markhoro: @DBDouble @shvogt @JDaviesPhD The brain changes in antidepressant use found in humans and animals is summarised here https://…
RT @physorg_health: Antidepressants can cause #withdrawalsymptoms—here's what you need to know @ConversationEDU https://t.co/eqGuOcetkh htt…
Antidepressants can cause #withdrawalsymptoms—here's what you need to know @ConversationEDU https://t.co/eqGuOcetkh https://t.co/ySlMbsyj7O
RT @markhoro: @DBDouble @shvogt @JDaviesPhD The brain changes in antidepressant use found in humans and animals is summarised here https://…
@DBDouble @shvogt @JDaviesPhD The brain changes in antidepressant use found in humans and animals is summarised here https://t.co/AUbIfqpsk7
@DrMcFillin https://t.co/d9q1cminw3 One-half of those taking antidepressants will experience withdrawal symptoms when they stop them. And then there's Tyler Black... A fabricated crisis? https://t.co/q7hO4JuyB2
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
A Conversation w/ Psychologist Anders Sørensen: Psychiatric Drug Withdrawal https://t.co/zotGbmxUA1 via @YouTube
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
RT @MedicatingNorm1: If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychol…
If you missed last week's FB LIVE, head over to the #MedicatingNormal YT CHANNEL & WATCH: "A Conversation w/ Psychologist Anders Sørensen: Psychiatric Drug Withdrawal" VIDEO LINK: https://t.co/aVbKFP12lf #psychology #psychotherapy #psychiatry #Withdrawal #tapering https://t.co/c3KGuEMRdO
Review: Antidepressant withdrawal syndrome is caused by adaptation of the brain to long-term use of the medication. It is a distinct phenomenon from addiction. Longer duration and higher doses, use of paroxetine or SNRIs may ↑ the incidence and severity https://t.co/WbYXOZcGiU https://t.co/pyV9kQUdYQ
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @MedicatingNorm1: "Estimating Risk of Antidepressant Withdrawal from a Review of Published Data" Link to Review: https://t.co/eFIlMqv…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
"Estimating Risk of Antidepressant Withdrawal from a Review of Published Data" Link to Review: https://t.co/eFIlMqvhnX #MedicatingNormal #antidepressants #AntidepressantWithdrawal #MentalHealth #psychiatry https://t.co/rMyeiHX43t
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
New post: Estimating Risk of Antidepressant Withdrawal from a Review of Published Data https://t.co/3WvE54cDxI #AdeleFramer #AndersSørensen #antidepressants
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: Good guidance on how to safely stop antidepressants here from @rcpsych: https://t.co/qjttcwv0B2 Paper is open access so can…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: Good guidance on how to safely stop antidepressants here from @rcpsych: https://t.co/qjttcwv0B2 Paper is open access so can…
RT @RadoslawStupak: Longer duration of treatment with antidepressants may increase the incidence and severity, and perhaps duration, of ant…
RT @Maudsley_pharm: The first scientific paper to estimate risk of antidepressant withdrawal based on drug, duration, dose and prior experi…
RT @markhoro: New article in CNS Drugs examining risk factors for antidepressant withdrawal. https://t.co/axNHZqCO4t With @survivingADs @Da…