(1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the so-called NDUFA genes, which regulate important enzymes of the mitochondria (we all know what malfunction of mitochondria means) https://t.co/44oFnTMRYa
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells.
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Jul 2022 – Aug 2024Where it's discussed
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X / Twitter101 posts
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AI synopsis
What people are saying
Numerous discussions reflect on the article's findings, highlighting terms like 'DNA methylation changes' and 'epigenetic biosignature,' which indicate a keen interest in the scientific aspects of long COVID. Phrases like 'big step towards a potential biomarker' and 'warrants further investigation' showcase a tone of optimism and urgency, contributing to the overall perception that this research may reshape future approaches to understanding long COVID.
Many discussions show general support for the conclusions of the research, recognizing the connection between DNA alterations and long-term COVID symptoms.
A high level of curiosity about the epigenetic findings is evident, as several posts reference their implications for future research and treatment.
While some posts delve into specific methodologies and findings from the study, others are more superficial, indicating a moderate level of engagement.
The consensus is that these findings could significantly influence both understanding and treatment approaches for post-acute COVID-19 syndrome.
Abstract in brief
- Postacute COVID19 syndrome (PACS) refers to lingering symptoms experienced after recovering from a COVID-19 infection.
- Researchers found a distinct DNA methylation (DNAm) pattern in patients with PACS compared to healthy controls and COVID-19 survivors, indicating epigenetic changes.
- This DNAm signature affects pathways related to angiotensin II, muscarinic receptor signaling, and protein interactions, which may influence vesicle formation and mitochondrial function.
Top posts
Most liked on X and Bluesky”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS. We cannot exclude the possibility that the PACS specific epigenetic signature is driven by a hidden SARS-CoV-2 reservoir.” https://t.co/b9dxPdcbKn
Ich finde, jetzt übertreiben diese eingebildeten Kranken aber wirklich. https://t.co/uhHGhyvatJ Die Studie ist hier nachzulesen: https://t.co/Dj2UUUW5zI
A reprogramming of which genes are active & which aren't, is visible in #LongCovid sufferers... A chemical group is switched on & removed from the DNA strand. Reduced methylation of a gene may be a sign of it becoming easier for the cell to read & use https://t.co/tFaUkvmXUU
This recent study found epigenetic alterations in LC patient peripheral blood cells that relate to signalling pathways many patients have autoantibodies for, and that affect mitochondrial function https://t.co/Zqzd3f2QDH
@PutrinoLab @patientled What do you think the most important finding of the last year was? I wonder if it was the recent study that showed DNA methylation changes related to receptor signalling, autoantibodies and mitochondrial dysfunction https://t.co/Zqzd3f2QDH
All mentions
Impact of COVID on DNA: Long COVID and Epigenetic Changes
As more people are infected with COVID-19, many experience lingering symptoms known as Long COVID. Research indicates this may be due to the virus altering DNA through distinct epigenetic changes. Discover the…
RT @Teheimar: Long Covid can be seen in Cell DNA and active genes. "Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosigna…
/5 Wir erkennen an diesem Artikel, dass #Covid Langzeitfolgen mit einer DNA Veränderung einhergehen können. Dazu gibt es einen einleitenden Text und eine Einordnung. Am Ende gibts die Primärquelle: https://t.co/sPpJiK4ioS
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells | Clinical Epigenetics | Full Text https://t.co/BQhRu8hQvz
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells | Clinical Epigenetics | Full Text https://t.co/lGn4LaC3YB
RT @ShaneyWright: A reprogramming of which genes are active & which aren't, is visible in #LongCovid sufferers... A chemical group is switc…
RT @ShaneyWright: A reprogramming of which genes are active & which aren't, is visible in #LongCovid sufferers... A chemical group is switc…
RT @ShaneyWright: A reprogramming of which genes are active & which aren't, is visible in #LongCovid sufferers... A chemical group is switc…
RT @ShaneyWright: A reprogramming of which genes are active & which aren't, is visible in #LongCovid sufferers... A chemical group is switc…
A reprogramming of which genes are active & which aren't, is visible in #LongCovid sufferers... A chemical group is switched on & removed from the DNA strand. Reduced methylation of a gene may be a sign of it becoming easier for the cell to read & use https://t.co/tFaUkvmXUU
@hbs_pro11 @fitterhappierAJ I think the results are numerous, and also include observed epigenetic modulation after infection. https://t.co/HXETzMQXNC
Long Covid can be seen in Cell DNA and active genes. "Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells" https://t.co/jZUb9sVoVs
@Lidsville @adriandix It's possible that C19 is changing how our bodies operate. LC is showing some of that. A reckoning might depend on a base state that won't return. Best hope is likely for a paradigm shift to support systems for all people (with disabilities). https://t.co/UYhMKoc41m
@GrutterStephan @lauwarmeravioli @Keksy19 @IloKhan @SwantjeBuchin @KarinSchmitt15 @ClaudiaHagan2 @BuchinSwantje @AndreBuchheim @WHYausHH @Hildy271 @Friedemann1 @Alexa122021 @ULTRAKAERL @Marina72886813 @Advokatin_B @ilona_pilgram @Prinz_KarLaF @tina63283141 @salbei77 @Kluengle @sunnydays2411 @DMNicky @_Serverschrank @gluckspilz_sven @werwaswo3 @Hervorrager @NrWinzidenz @RWittenbrink @heikerichta @JrgBehlen @Ey75518304 @alcesmoose @SchultheisEva @SwelaSoh @Glonntaler @aluhuten @MarieASchneide1 @kerstinPe3 @Brigittemko @yoga_and_more @FalkenaugeM @sus_oe @Beaute_du_Noir_ @HolleBMC @Karl_Lauterbach @ewyler @RolandJger4 https://t.co/5pe9XZjyRq
@NikavonAquin @LangzeitC https://t.co/5pe9XZjyRq
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells | Clinical Epigenetics | Full Text
This recent study found epigenetic alterations in LC patient peripheral blood cells that relate to signalling pathways many patients have autoantibodies for, and that affect mitochondrial function https://t.co/Zqzd3f2QDH
RT @towB: #Epigenom im Visier: Eine aktuelle Studie der Universität Linköping zeigt, dass es epigenetische Unterschiede zwischen Genesenen,…
RT @NBoydGibbins: @PutrinoLab @patientled What do you think the most important finding of the last year was? I wonder if it was the recent…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
Potential Biomarker for #LongCovid and #MECFS? “We compared DNAm patterns in patients with PACS with those in controls and in healthy COVID-19 convalescents and found a unique DNAm signature in PACS patients.” https://t.co/CWDpZpIXpA
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @MelanieWeckert: Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells |…
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells | Epigenetic changes in Long Covid (affecting histamine, mitochondria etc) https://t.co/fWfkN7cdLd
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
Manual addition: “Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells” https://t.co/vHXwKr7suO
Defining post-acute #COVID19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells https://t.co/czd97ZTEY6
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
@Bozzetto3000 @tomdabassman @georgrestle Dann können sie mir sicher zeigen wo die Studie falsch liegt https://t.co/7hkzstLM4B
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
RT @NBoydGibbins: @PutrinoLab @patientled What do you think the most important finding of the last year was? I wonder if it was the recent…
RT @Gronnet: ”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS…
”our finding of an epigenetically modified module at the core of mitochondrial function warrants further investigation in PACS. We cannot exclude the possibility that the PACS specific epigenetic signature is driven by a hidden SARS-CoV-2 reservoir.” https://t.co/b9dxPdcbKn
@PutrinoLab @patientled What do you think the most important finding of the last year was? I wonder if it was the recent study that showed DNA methylation changes related to receptor signalling, autoantibodies and mitochondrial dysfunction https://t.co/Zqzd3f2QDH
@annemariemox https://t.co/fbbX0k4kU9
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
https://t.co/klO8DTIscc
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
Biosignatur in Longcovid / PASC betrifft auch mitochondriale Funktionen. Die von DeBoer und Petrache beschriebene mitochondriale Dysfunktion wird wahrscheinlicher. https://t.co/7BPnKwqje6 https://t.co/P3xTcNwbVj
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
RT @RWittenbrink: Fatiguesyndrom einbeziehen, sind erforderlich. Der Link zur Studie und einem aktuellen Bericht: https://t.co/bcYDT6Tt1y…
RT @leowmya: (1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the…
(1/2) Big step towards a potential #LongCovid and #MECFS biomarker: Post-Covid sufferers had blocked DNA attachments to the so-called NDUFA genes, which regulate important enzymes of the mitochondria (we all know what malfunction of mitochondria means) https://t.co/44oFnTMRYa
RT @RWittenbrink: Fatiguesyndrom einbeziehen, sind erforderlich. Der Link zur Studie und einem aktuellen Bericht: https://t.co/bcYDT6Tt1y…
Ich finde, jetzt übertreiben diese eingebildeten Kranken aber wirklich. https://t.co/uhHGhyvatJ Die Studie ist hier nachzulesen: https://t.co/Dj2UUUW5zI
RT @RWittenbrink: Fatiguesyndrom einbeziehen, sind erforderlich. Der Link zur Studie und einem aktuellen Bericht: https://t.co/bcYDT6Tt1y…
RT @RWittenbrink: Fatiguesyndrom einbeziehen, sind erforderlich. Der Link zur Studie und einem aktuellen Bericht: https://t.co/bcYDT6Tt1y…
#Epigenom im Visier: Eine aktuelle Studie der Universität Linköping zeigt, dass es epigenetische Unterschiede zwischen Genesenen, nie mit SARS-CoV-2 infizierten Gesunden und #PostCovid Betroffenen gibt. https://t.co/zxBnivoX71
RT @RWittenbrink: Fatiguesyndrom einbeziehen, sind erforderlich. Der Link zur Studie und einem aktuellen Bericht: https://t.co/bcYDT6Tt1y…
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells — Nikesjö et al. https://t.co/cJw83swOdQ 10/15
RT @agingdoc1: Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells https://t.…
RT @agingdoc1: Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells https://t.…
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells https://t.co/LJVl7jeTgt https://t.co/V9czOfLh80
Frida Nikesjö, Shumaila Sayyab, Lovisa Karlsson et al. Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells, 12 July 2022, PREPRINT (Version 1) available at Research Square [https://t.co/m6ArSqF85F]
Defining post-acute COVID-19 syndrome (PACS) by an epigenetic biosignature in peripheral blood mononuclear cells #covid https://t.co/wrIQp67KP1