Aging Cell January 2023 PMID 36547021

Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts.

Sophia Wedel, Ines Martic, Lena Guerrero Navarro, Christian Ploner, Gerhard Pierer, Pidder Jansen-Dürr, Maria Cavinato

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Mentions

12
Peak: 4 in Jan 2023
across 2 sources since Dec 2022

Extended reach

149,248
potential audience

Total likes

2,888

Video views

95,534

Mentions per month

Dec 2022 – Oct 2024

Where it's discussed

  • X / Twitter10 posts
  • YouTube2 videos

AI synopsis

What people are saying

Throughout the discussions, participants emphasize GDF15's role in delaying skin aging and mitochondrial function, with phrases like 'crucial for longevity' and 'impact on youthful skin,' showing active interest and recognition of its potential. The tone suggests a blend of scientific curiosity and recognition of the study's importance, though some comments remain general, indicating room for deeper engagement.

AgreementModerate agreement

Most discussions recognize the importance of GDF15 in cellular aging and mitochondrial health, indicating general agreement with the study's findings.

InterestHigh interest

Posts show high interest due to focus on longevity, skin aging, and cellular processes, reflecting active engagement with the topic.

EngagementModerate engagement

Participants reference specific biological mechanisms and implications, demonstrating thoughtful reactions and connections beyond surface-level commentary.

ImpactModerate impact

The discussions highlight the potential significance of GDF15 research for aging and health, suggesting a moderate to high perceived impact.

Abstract in brief

  • GDF15 is a cytokine involved in stress responses, and this study shows that when its levels are reduced in human skin cells, it causes mitochondrial problems and makes the cells age prematurely.
  • Loss of GDF15 in skin cells leads to aging features like thinner skin in a 3D human skin model, highlighting its role in maintaining healthy skin.
  • Overall, GDF15 helps keep mitochondria functioning properly and delays cell aging, suggesting it could be important for preventing skin aging and other age-related changes.]

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts https://t.co/UIggaL2Yky https://t.co/IzqEWn2eq5

Dec 23, 2022 · 8 likes · 1 share · 41,789 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts https://t.co/JyVeSPICTK

Jan 5, 2023 · 1 like · 4,791 followers View post →
Advanced Biology
@Adv_Biology · X

Checkout this great Short Communication from Aging Cell, entitled 'Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts' Click for more! #AcademicChatter #Aging https://t.co/X9vhbZZ1HM

Jan 12, 2023 · 1 like · 1 share · 635 followers View post →
Jake Hunter
@JakeHunter88 · X

How to Scientifically Live Longer, Lose Fat, and Become Resilient https://t.co/QD2Oyuy9dF via @YouTube

Oct 13, 2024 · 1,601 followers View post →
Simon H Parson
@NEAnatomist · X

RT @Adv_Biology: Checkout this great Short Communication from Aging Cell, entitled 'Depletion of growth differentiation factor 15 (GDF15) l…

Jan 13, 2023 · 1 share · 1,177 followers View post →
blubber_bones
@blubber_bones · X

The Only Thing More Important than Protein for Longevity… https://t.co/o3NCQTN4XF

Nov 30, 2023 · 1,096 followers View post →

All mentions

Jake Hunter
@JakeHunter88 · X

How to Scientifically Live Longer, Lose Fat, and Become Resilient https://t.co/QD2Oyuy9dF via @YouTube

Oct 13, 2024 · 1,601 followers View post →
blubber_bones
@blubber_bones · X

How to Scientifically Live Longer, Lose Fat, and Become Resilient https://t.co/37XebZzIog via @YouTube

Oct 13, 2024 · 1,096 followers View post →
Steven Bartolotti
@StevenBartolot2 · X

https://t.co/8thynWKqzs

Oct 13, 2024 · 56 followers View post →
blubber_bones
@blubber_bones · X

The Only Thing More Important than Protein for Longevity… https://t.co/o3NCQTN4XF

Nov 30, 2023 · 1,096 followers View post →
Simon H Parson
@NEAnatomist · X

RT @Adv_Biology: Checkout this great Short Communication from Aging Cell, entitled 'Depletion of growth differentiation factor 15 (GDF15) l…

Jan 13, 2023 · 1 share · 1,177 followers View post →
Advanced Biology
@Adv_Biology · X

Checkout this great Short Communication from Aging Cell, entitled 'Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts' Click for more! #AcademicChatter #Aging https://t.co/X9vhbZZ1HM

Jan 12, 2023 · 1 like · 1 share · 635 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts https://t.co/IwlfaRcvHn https://t.co/X6HUOnAZ2J @DBT_inStem @iiscbangalore @IISERPune @iitgn @clriindia @ccmb_csir @ICGEBNewDelhi https://t.co/kuJgvo3VQ4

Jan 7, 2023 · 882 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts https://t.co/JyVeSPICTK

Jan 5, 2023 · 1 like · 4,791 followers View post →
BillOckham
@BillOccham0 · X

RT @agingdoc1: Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human d…

Dec 23, 2022 · 1 share · 584 followers View post →
Agingdoc
@agingdoc1 · X

Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts https://t.co/UIggaL2Yky https://t.co/IzqEWn2eq5

Dec 23, 2022 · 8 likes · 1 share · 41,789 followers View post →