Nat Commun December 2022 PMID 36572698

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.

Madison N Wilson, Martin Thunemann, Xin Liu, Yichen Lu, Francesca Puppo, Jason W Adams, Jeong-Hoon Kim, Mehrdad Ramezani, Donald P Pizzo, Srdjan Djurovic, Ole A Andreassen, Abed AlFatah Mansour, Fred H Gage, Alysson R Muotri, Anna Devor

Mentions

141
Peak: 24 in Dec 2022
across 5 sources since Dec 2022

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692,289
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Total likes

95

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Dec 2022 – Aug 2024

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AI synopsis

What people are saying

Several posts actively praised the research, calling it a 'major breakthrough' and congratulating the authors, which demonstrates appreciation for its novelty and importance. Others expressed curiosity about the techniques and potential applications, highlighting the study's relevance. The tone varies from enthusiastic to neutral, emphasizing both interest and recognition of the scientific value, supporting the overall positive perception of its impact.

AgreementModerate agreement

Most discussions express positive acknowledgment of the study, recognizing it as an important scientific advancement. Words like 'congratulations' and references to the work as 'successful' indicate general agreement on its significance.

InterestHigh interest

Posts show strong curiosity and intrigue, with many highlighting the novelty of the research. Terms like 'exciting,' 'interesting,' and 'revolutionary' reflect high interest in the topic and its implications.

EngagementModerate engagement

While some messages include technical details about the methods used and potential applications, the overall tone is respectful and informational rather than deeply analytical or critical, indicating moderate engagement.

ImpactModerate impact

Participants perceive the research as having meaningful scientific and therapeutic potential, though few express a sense of immediate or transformative impact. The focus is on its contribution to neuroscience and biomedical research rather than on societa

Abstract in brief

  • The study demonstrates that human cortical organoids implanted into the brains of mice can develop vascular connections and respond to visual stimuli with activity similar to the surrounding cortex, indicating functional connectivity.
  • Using advanced imaging and electrophysiological techniques, researchers observed increased neural activity and synchronized responses, confirming the organoids' integration into the host brain's sensory network.
  • The findings suggest that organoids can establish meaningful connections with the brain's neural circuits in vivo, providing a promising platform for studying brain development, dysfunction, and potential therapeutic applications.]

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New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex https://t.co/tbjbbVyXAP

Dec 26, 2022 · 43 likes · 6 shares · 1,953 followers View post →
Abed A. Mansour
@mansour_abed_A · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.. Congratulations to ⁦⁦⁦@DuyguKuzum⁩ ⁦@AnnaDevor⁩ and to all authors. Happy to contribute to this study. https://t.co/AnSTuDsiVI

Dec 27, 2022 · 21 likes · 2 shares · 854 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex” by Duygu Kuzum et al. Nature Communications https://t.co/NdqNDpiD3h

Dec 29, 2022 · 19 likes · 5 shares · 505,845 followers View post →
Agingdoc
@agingdoc1 · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex Madison Wilson, @AnnaDevor @DuyguKuzum & coauthors. https://t.co/vs6DyA0mxI @NatureComms https://t.co/l7ESIwhH8V

Dec 29, 2022 · 6 likes · 41,786 followers View post →
biophotonicat
@biophotonicat · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex (relevance: 54%) https://t.co/0nA4Y7i9Ke #biophotonics #biomedicaloptics

Dec 26, 2022 · 3 likes · 2 shares · 1,528 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Wilson MN, Thunemann M, Liu X, et al. Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. Nat Commun. 2022;13(1):7945. doi: 10.1038/s41467-022-35536-3 https://t.co/0IYGlq0VkQ

Jan 4, 2023 · 1 like · 1 share · 15,688 followers View post →

All mentions

Kristie Iushkova
@KristieIushkova · X

@Incrementallog1 @ToBornin @LisaMcGee0802 @CorinneNokel @Ryansikorski10 @Anti5GWarrior @fear2022 @Fynnderella1 @MrPatriot76 @CelestialReport @jorgeluis_svh @allinsyde @Eleventhstar1 @BarbarasBack @Yohmini2 @sophiadahl1 @AdhesionsOrg @CanningPharm @zeee_media @drloveariyana @Stuckelberger @naomirwolf @ganaha_masako @DrAnaMihalcea @Doctor_I_am_The @carrie_madej @lqcnternational @ShabnamPalesaMo @BusyDrT @Kingston_Truth @la5acolumna @DJSpeicher @MelissaMcAtee92 @SenseReceptor @gregreese @djindji5 @DrLuisServinde1 @super1990 @drcole12 @raoult_didier @CShoemakerMD @BrianBRose @SikhForTruth @NicolasPichot6 @DrChrisNorthrup @DrHenryEaly @liz_churchill10 @AllBiteNoBark88 •Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex @ https://t.co/6FsJ6ihMDC and @ https://t.co/f4ZKVjzvez

Aug 3, 2024 · 1 like · 3,458 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex https://t.co/koH0kqNhdW

Jun 14, 2024 · 31,605 followers View post →
Bryan Bishop
@kanzure · X

actually, biological neurons are plug-and-play compatible: "Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex" https://t.co/ch3cLJGpo6

Mar 6, 2023 · 15,747 followers View post →
ryo694
@ryo694 · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex | Nature Communications https://t.co/vLbPr1rNCJ

Jan 22, 2023 · 1,388 followers View post →
Manuel Sánchez
@ManoloSanchezA · X

RT @MASogorb: Implantan con éxito organoides de cerebro humano en cerebros de ratón https://t.co/yxlLT3z86S Más información: Multimodal mon…

Jan 5, 2023 · 1 share · 1,725 followers View post →
Norio Nakatsuji
@norionakatsuji · X

RT @norionakatsuji: 元論文→ Reference: Wilson MN, Thunemann M, Liu X, et al. Multimodal monitoring of human cortical organoids implanted in mi…

Jan 5, 2023 · 1 share · 15,688 followers View post →
Miguel Ángel Sogorb
@MASogorb · X

Implantan con éxito organoides de cerebro humano en cerebros de ratón https://t.co/yxlLT3z86S Más información: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex https://t.co/yolfVWh5dJ

Jan 5, 2023 · 1 share · 158 followers View post →
な bot
@NeuroNNNNN_bot · X

[Nat. Commun.] Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex https://t.co/io5j6tq9ml

Jan 4, 2023 · 26 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Reference: Wilson MN, Thunemann M, Liu X, et al. Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. Nat Commun. 2022;13(1):7945. doi: 10.1038/s41467-022-35536-3 https://t.co/0IYGlq0VkQ

Jan 4, 2023 · 1 like · 1 share · 15,688 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex https://t.co/V8PlH6FM3z https://t.co/Vu5LI94TAa

Dec 31, 2022 · 24,156 followers View post →
Javier Díaz-Nido
@Javier_DiazNido · X

RT @NeuroscienceNew: “Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex”…

Dec 30, 2022 · 5 shares · 1,834 followers View post →
SiddiqaAlee
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RT @NeuroscienceNew: “Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex”…

Dec 29, 2022 · 5 shares · 160 followers View post →
Endquire
@Endquire · X

RT @NeuroscienceNew: “Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex”…

Dec 29, 2022 · 5 shares · 401 followers View post →
DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X

RT @NeuroscienceNew: “Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex”…

Dec 29, 2022 · 5 shares · 1,470 followers View post →
PORCHE
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RT @NeuroscienceNew: “Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex”…

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Neuroscience News
@NeuroscienceNew · X

“Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex” by Duygu Kuzum et al. Nature Communications https://t.co/NdqNDpiD3h

Dec 29, 2022 · 19 likes · 5 shares · 505,845 followers View post →
Matt Kennedy
@mekapk_kennedy · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex | Nature Communications https://t.co/l1pEGXPYn7

Dec 29, 2022 · 1 like · 43 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex | Nature Communications https://t.co/zFX4RODXH3

Dec 29, 2022 · 2,568 followers View post →
USBrainAlliance
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RT @NeuroPaperBot: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex http…

Dec 29, 2022 · 6 shares · 4,387 followers View post →
Agingdoc
@agingdoc1 · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex Madison Wilson, @AnnaDevor @DuyguKuzum & coauthors. https://t.co/vs6DyA0mxI @NatureComms https://t.co/l7ESIwhH8V

Dec 29, 2022 · 6 likes · 41,786 followers View post →
anirudh
@AniRude95 · X

RT @mansour_abed_A: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.. C…

Dec 28, 2022 · 2 shares · 484 followers View post →
Angel Lizandro Polanco
@TheOrganoidBoy · X

RT @mansour_abed_A: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.. C…

Dec 27, 2022 · 2 shares · 344 followers View post →
Shirsho Shreyan
@shirsho_shreyan · X

RT @NeuroPaperBot: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex http…

Dec 27, 2022 · 6 shares · 228 followers View post →
Abed A. Mansour
@mansour_abed_A · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.. Congratulations to ⁦⁦⁦@DuyguKuzum⁩ ⁦@AnnaDevor⁩ and to all authors. Happy to contribute to this study. https://t.co/AnSTuDsiVI

Dec 27, 2022 · 21 likes · 2 shares · 854 followers View post →
biophotonicat
@biophotonicat · X

RT @biophotonicat: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex (rel…

Dec 26, 2022 · 2 shares · 1,528 followers View post →
Natalia Suárez
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RT @biophotonicat: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex (rel…

Dec 26, 2022 · 2 shares · 441 followers View post →
biophotonicat
@biophotonicat · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex (relevance: 54%) https://t.co/0nA4Y7i9Ke #biophotonics #biomedicaloptics

Dec 26, 2022 · 3 likes · 2 shares · 1,528 followers View post →
Barbara Hawrot
@Biologicalai11 · X

RT @NeuroPaperBot: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex http…

Dec 26, 2022 · 6 shares · 179 followers View post →
Takei Lab
@LabTakei · X

Nature Communications volume 13, Article number: 7945 (2022) Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex Madison N. Wilson, Anna Devor & Duygu Kuzum et al https://t.co/M3gIeF4pzP

Dec 26, 2022 · 1,066 followers View post →
日本神経化学会(準公式)
@neurochem_JPsoc · X

RT @NeuroPaperBot: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex http…

Dec 26, 2022 · 6 shares · 958 followers View post →
The ReNeural Project
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RT @NeuroPaperBot: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex http…

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Jibran Khokhar
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RT @NeuroPaperBot: Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex http…

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New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex https://t.co/tbjbbVyXAP

Dec 26, 2022 · 43 likes · 6 shares · 1,953 followers View post →