New #JITC article: T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins https://t.co/oVcGi8S1D8 @SchlichtnerS https://t.co/SuN3cC8Xqa
T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins.
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Jan 2023 – Aug 2023Where it's discussed
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X / Twitter5 posts
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News2 articles
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YouTube1 videos
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What people are saying
Several discussions explicitly praise the importance of galectin-9 as an immune suppressor and potential target, using words like 'strengthens importance' and 'attractive target,' indicating high interest and perceived impact. The tone suggests anticipation for further research and therapeutic development, demonstrating moderate engagement through technical references and acknowledgment of new receptor discoveries.
Most discussions recognize the significance of galectin-9 as a target in cancer immunotherapy, showing agreement with the findings.
Posters display high interest, referencing new research and emphasizing galectin-9's role in tumor immune evasion.
Comments often delve into the mechanisms and implications, indicating a moderate level of deep engagement.
The discussions highlight potential for therapeutic advances and increased focus on galectin-9, reflecting a high impact perception.
Abstract in brief
- T lymphocytes can stimulate human solid tumor cancer cells to produce and secrete galectin9, a protein that suppresses immune responses, through two mechanisms involving surface translocation and autophagy-related secretion.
- Galectin9 is highly expressed in various aggressive and common cancers, and its soluble form may have a stronger immunosuppressive effect systemically compared to the surface-bound form.
- The study used multiple laboratory techniques and in vivo mouse models to confirm that the secretion process depends on specific protein carriers since galectin9 itself lacks a typical secretion signal.]
Top posts
Most liked on X and BlueskyT lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins | Journal for ImmunoTherapy of Cancer https://t.co/YisqK562ae
Additional research published in @jitcancer strengthens importance of galectin-9 as an attractive target in #solidtumors and #AML: T cells induce high levels of gal-9 in solid cancers causing immunosuppression & VISTA identified as a new receptor for gal-9 https://t.co/9kJgHUX1op
T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Stephanie Schlichtner https://t.co/ex84nhTYHV
All mentions
T Cells Stimulate Cancer Cells to Secrete Immunosuppressive Galectin-9
T lymphocytes induce human solid tumor cells to secrete galectin-9, a protein that suppresses immune responses, through mechanisms involving surface translocation and autophagy. Galectin-9 plays a key role in tumor…
Additional research published in @jitcancer strengthens importance of galectin-9 as an attractive target in #solidtumors and #AML: T cells induce high levels of gal-9 in solid cancers causing immunosuppression & VISTA identified as a new receptor for gal-9 https://t.co/9kJgHUX1op
RT @weldeiry: T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosup…
T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins | Journal for ImmunoTherapy of Cancer https://t.co/YisqK562ae
New #JITC article: T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins https://t.co/oVcGi8S1D8 @SchlichtnerS https://t.co/SuN3cC8Xqa
T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Stephanie Schlichtner https://t.co/ex84nhTYHV