J Immunother Cancer January 2023 PMID 36599470

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins.

Stephanie Schlichtner, Inna M Yasinska, Gurprit S Lall, Steffen M Berger, Sabrina Ruggiero, Dietmar Cholewa, Nijas Aliu, Bernhard F Gibbs, Elizaveta Fasler-Kan, Vadim V Sumbayev

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Mentions

8
Peak: 5 in Jan 2023
across 3 sources since Jan 2023

Extended reach

33,843
potential audience

Total likes

6

Video views

203

Mentions per month

Jan 2023 – Aug 2023

Where it's discussed

  • X / Twitter5 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions explicitly praise the importance of galectin-9 as an immune suppressor and potential target, using words like 'strengthens importance' and 'attractive target,' indicating high interest and perceived impact. The tone suggests anticipation for further research and therapeutic development, demonstrating moderate engagement through technical references and acknowledgment of new receptor discoveries.

AgreementModerate agreement

Most discussions recognize the significance of galectin-9 as a target in cancer immunotherapy, showing agreement with the findings.

InterestHigh interest

Posters display high interest, referencing new research and emphasizing galectin-9's role in tumor immune evasion.

EngagementModerate engagement

Comments often delve into the mechanisms and implications, indicating a moderate level of deep engagement.

ImpactHigh impact

The discussions highlight potential for therapeutic advances and increased focus on galectin-9, reflecting a high impact perception.

Abstract in brief

  • T lymphocytes can stimulate human solid tumor cancer cells to produce and secrete galectin9, a protein that suppresses immune responses, through two mechanisms involving surface translocation and autophagy-related secretion.
  • Galectin9 is highly expressed in various aggressive and common cancers, and its soluble form may have a stronger immunosuppressive effect systemically compared to the surface-bound form.
  • The study used multiple laboratory techniques and in vivo mouse models to confirm that the secretion process depends on specific protein carriers since galectin9 itself lacks a typical secretion signal.]

Top posts

Most liked on X and Bluesky
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins https://t.co/oVcGi8S1D8 @SchlichtnerS https://t.co/SuN3cC8Xqa

Jan 5, 2023 · 3 likes · 9,359 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins | Journal for ImmunoTherapy of Cancer https://t.co/YisqK562ae

Jan 13, 2023 · 1 like · 1 share · 18,508 followers View post →
PureTech
@PureTechH · X

Additional research published in @jitcancer strengthens importance of galectin-9 as an attractive target in #solidtumors and #AML: T cells induce high levels of gal-9 in solid cancers causing immunosuppression & VISTA identified as a new receptor for gal-9 https://t.co/9kJgHUX1op

Aug 3, 2023 · 1 like · 1 share · 4,301 followers View post →
NK papers
@NK_papers · X

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Stephanie Schlichtner https://t.co/ex84nhTYHV

Jan 5, 2023 · 1,284 followers View post →

All mentions

PureTech
@PureTechH · X

Additional research published in @jitcancer strengthens importance of galectin-9 as an attractive target in #solidtumors and #AML: T cells induce high levels of gal-9 in solid cancers causing immunosuppression & VISTA identified as a new receptor for gal-9 https://t.co/9kJgHUX1op

Aug 3, 2023 · 1 like · 1 share · 4,301 followers View post →
Dan Komaromi
@DanKomaromi · X

RT @weldeiry: T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosup…

Jan 13, 2023 · 1 share · 183 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins | Journal for ImmunoTherapy of Cancer https://t.co/YisqK562ae

Jan 13, 2023 · 1 like · 1 share · 18,508 followers View post →
Journal for ImmunoTherapy of Cancer
@jitcancer · X

New #JITC article: T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins https://t.co/oVcGi8S1D8 @SchlichtnerS https://t.co/SuN3cC8Xqa

Jan 5, 2023 · 3 likes · 9,359 followers View post →
NK papers
@NK_papers · X

T lymphocytes induce human cancer cells derived from solid malignant tumors to secrete galectin-9 which facilitates immunosuppression in cooperation with other immune checkpoint proteins by Stephanie Schlichtner https://t.co/ex84nhTYHV

Jan 5, 2023 · 1,284 followers View post →