Nat Commun January 2023 PMID 36609402

Molecular subtypes of ALS are associated with differences in patient prognosis.

Jarrett Eshima, Samantha A O'Connor, Ethan Marschall, Robert Bowser, Christopher L Plaisier, Barbara S Smith

Mentions

18
Peak: 13 in Jan 2023
across 3 sources since Jan 2023

Extended reach

86,791
potential audience

Total likes

47

Video views

15

Mentions per month

Jan 2023 – Nov 2023

Where it's discussed

  • X / Twitter15 posts
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects strong agreement with the importance of identifying molecular subtypes, as seen in phrases like 'significant step towards understanding the heterogeneity' and 'great use of dataset,' which demonstrate appreciation for the research's contribution. The mentions of 'different clinical outcomes' and 'understanding prognosis' show an active interest in the study's implications for ALS treatment and diagnosis, though some comments are more straightforward and less emotionally driven, leading to moderate interest and engagement scores.

AgreementStrong agreement

Most discussions strongly support the significance of the research findings, emphasizing its importance in understanding ALS heterogeneity.

InterestModerate interest

While the topic is quite specialized, some posts show genuine curiosity about the implications of categorizing ALS subtypes.

EngagementModerate engagement

Participants reference specific datasets and the potential for future research, indicating meaningful engagement beyond mere acknowledgment.

ImpactHigh impact

The discussions highlight how this research could advance personalized medicine and improve prognosis accuracy, indicating high potential impact.

Abstract in brief

  • Amyotrophic Lateral Sclerosis (ALS) is a complicated neurodegenerative disease that varies widely among patients in terms of age of onset, progression of symptoms, treatment effectiveness, and overall disease duration.
  • A study was conducted using brain tissue samples from 208 ALS patients to analyze these variations and understand the underlying pathology better, focusing on the role of transposable elements (TEs) in the disease.
  • The researchers identified three distinct molecular subtypes of ALS patients, each linked to different survival outcomes, indicating that various mechanisms may contribute to the clinical differences seen in ALS.

Top posts

Most liked on X and Bluesky
Jack Humphrey
@JackHumphrey_ · X

Molecular subtypes of ALS are associated with differences in patient prognosis: https://t.co/EDTQS5Huvh Another great use of the NYGC ALS Consortium dataset!

Jan 15, 2023 · 23 likes · 1 share · 894 followers View post →
ShorterLab
@ShorterLab · X

Molecular subtypes of ALS are associated with differences in patient prognosis: https://t.co/4NPC4TnOcz

Jan 6, 2023 · 13 likes · 12,102 followers View post →
Nat Rev Neurology
@NatRevNeurol · X

Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 10 likes · 4 shares · 46,492 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/PZuSt8znSk

Jan 6, 2023 · 1 like · 1 share · 1,953 followers View post →
Robert West, PhD ✝️
@westr · X

RT @NeuroPaperBot: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/PZuSt8znSk

Jan 6, 2023 · 1 share · 19,312 followers View post →
Javier Díaz-Nido
@Javier_DiazNido · X

RT @NatRevNeurol: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 4 shares · 1,834 followers View post →

All mentions

Eric Hwang Lab (黃兆祺實驗室)
@EHLabNYCU · X

This year, an article by Barbara Smith's team delves into ALS patient stratification, using transposable elements to identify and characterize three distinct molecular subtypes with significant differences in patient survival. https://t.co/veUyQjEu6B

Nov 21, 2023 · 48 followers View post →
Eric Hwang Lab (黃兆祺實驗室)
@EHLabNYCU · X

The study conducted by SBHSE @ASU researchers shows that ALS can be categorized into three distinct molecular subtypes, each with varying patient clinical outcomes. This is a significant step towards understanding the heterogeneity of ALS. https://t.co/veUyQjDWh3

Jun 5, 2023 · 48 followers View post →
Alleo Labs
@alleolabs · X

RT @JackHumphrey_: Molecular subtypes of ALS are associated with differences in patient prognosis: https://t.co/EDTQS5Huvh Another great u…

Jan 16, 2023 · 1 share · 180 followers View post →
Jack Humphrey
@JackHumphrey_ · X

Molecular subtypes of ALS are associated with differences in patient prognosis: https://t.co/EDTQS5Huvh Another great use of the NYGC ALS Consortium dataset!

Jan 15, 2023 · 23 likes · 1 share · 894 followers View post →
トウモロコシトシオ
@morokoshitoshio · X

RT @NatRevNeurol: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 4 shares · 9 followers View post →
Javier Díaz-Nido
@Javier_DiazNido · X

RT @NatRevNeurol: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 4 shares · 1,834 followers View post →
ong beng hooi
@ongbenghooi1 · X

RT @NatRevNeurol: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 4 shares · 545 followers View post →
Vanja Tepavcevic
@TepavcevicVanja · X

RT @NatRevNeurol: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 4 shares · 902 followers View post →
Nat Rev Neurology
@NatRevNeurol · X

Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/LHJTxPfGEU

Jan 9, 2023 · 10 likes · 4 shares · 46,492 followers View post →
IronBiologyBot
@IronBiologyBot · X

Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/XDF59rc3om #IronBiology #BioIron #Iron

Jan 8, 2023 · 288 followers View post →
Transcriptomes
@transcriptomes · X

Molecular subtypes of ALS are associated with differences in patient prognosis. https://t.co/iAJl9YskIW

Jan 8, 2023 · 1,809 followers View post →
ShorterLab
@ShorterLab · X

Molecular subtypes of ALS are associated with differences in patient prognosis: https://t.co/4NPC4TnOcz

Jan 6, 2023 · 13 likes · 12,102 followers View post →
Robert West, PhD ✝️
@westr · X

RT @NeuroPaperBot: Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/PZuSt8znSk

Jan 6, 2023 · 1 share · 19,312 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Molecular subtypes of ALS are associated with differences in patient prognosis https://t.co/PZuSt8znSk

Jan 6, 2023 · 1 like · 1 share · 1,953 followers View post →
BrainSights iOS App
@BrainSightsApp · X

Molecular subtypes of ALS are associated with differences in patient prognosis - Nature - ALS via BrainSights for iOS https://t.co/VoT6t8iVLK

Jan 6, 2023 · 312 followers View post →