PubHawk
Signal Transduct Target Ther January 2023 PMID 36609561

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy.

Pei-Pei Zhang, Zhi-Cheng He, Xiao-Hong Yao, Rui Tang, Jie Ma, Tao Luo, Chuhong Zhu, Tian-Ran Li, Xindong Liu, Dingyu Zhang, Shuyang Zhang, Yi-Fang Ping, Ling Leng, Xiu-Wu Bian

Download social card

Mentions

18
Peak: 9 in Jan 2023
across 4 sources since Jan 2023

Extended reach

117,884
potential audience

Total likes

21

Video views

230

Mentions per month

Jan 2023 – Dec 2023

Where it's discussed

  • X / Twitter11 posts
  • News3 articles
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

The interactions highlight key aspects of the study, such as mentioning 'microglia activation' and 'immune-related proteins', indicating an analytical tone and genuine engagement with scientific details. Words like 'significant', 'damage', and 'potential targets' emphasize the perceived importance and potential impact of the research, reflecting both high interest and recognition of its scientific value.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with many referencing the detailed cellular and proteomic findings, indicating support for the study's conclusions.

InterestHigh interest

The posts demonstrate high interest, as they delve into details about immune cell infiltration and brain damage, reflecting curiosity and concern.

EngagementModerate engagement

Discussions show a moderate level of engagement, with some posts mentioning specific cellular mechanisms and potential therapeutic implications.

ImpactHigh impact

The discussions suggest the article could have high impact by advancing understanding of COVID-19 neurological effects and influencing future research or treatment approaches.

Abstract in brief

  • The study investigates the brain damage caused by COVID-19, revealing extensive neuroinflammation, blood-brain barrier damage, and infiltration of immune cells like monocytes and T lymphocytes in critically ill patients.
  • Key cellular changes include activation of microglia and astrocytes, microphagocytosis, and the presence of microglia nodules, along with signs of edema, hemorrhage, and infarction.
  • Proteomic analysis shows that COVID-19 brains have increased levels of immune-related proteins, while proteins involved in brain development and protection are decreased, highlighting potential targets for therapy.
Read the full abstract

Top posts

Most liked on X and Bluesky
Outbreak Updates
@outbreakupdates · X

Covid Autopsy

Jan 9, 2023 · 9 likes · 2 shares · 100,693 followers View post →
Stray
@K9FCR · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy | Signal Transduction and Targeted Therapy https://t.co/QO9lZJ3vZl

Jan 9, 2023 · 5 likes · 1 share · 13,009 followers View post →
PostX #UniteToFight2024
@TeamPostX · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy. We remember functional reprogramming of monocytes (https://t.co/3tHOGmc6Vp) … https://t.co/t3PS6gDKzh

Jan 9, 2023 · 2,055 followers View post →
Blood brain barrier
@bbbpapers · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy https://t.co/xq0pjM7toA

Jan 8, 2023 · 773 followers View post →
ポーラカタリーナ is in her 'healing my inner child' era.
@paulakatarina · X

RT @outbreakupdates: Covid Autopsy

Jan 9, 2023 · 2 shares · 463 followers View post →
kai
@kai958531911 · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy https://t.co/SyLTOy65kH

Jan 9, 2023 · 265 followers View post →

All mentions

es/iode
@es_iode · X

Apr 30, 2023 · 36 followers View post →
es/iode
@es_iode · X

Mar 17, 2023 · 36 followers View post →
es/iode
@es_iode · X

Jan 20, 2023 · 36 followers View post →
grienne
@grienne2 · X

RT @outbreakupdates: Covid Autopsy

Jan 9, 2023 · 2 shares · 116 followers View post →
Stray
@K9FCR · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy | Signal Transduction and Targeted Therapy https://t.co/QO9lZJ3vZl

Jan 9, 2023 · 5 likes · 1 share · 13,009 followers View post →
kai
@kai958531911 · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy https://t.co/SyLTOy65kH

Jan 9, 2023 · 265 followers View post →
PostX #UniteToFight2024
@TeamPostX · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy. We remember functional reprogramming of monocytes (https://t.co/3tHOGmc6Vp) … https://t.co/t3PS6gDKzh

Jan 9, 2023 · 2,055 followers View post →
ポーラカタリーナ is in her 'healing my inner child' era.
@paulakatarina · X

RT @outbreakupdates: Covid Autopsy

Jan 9, 2023 · 2 shares · 463 followers View post →
Outbreak Updates
@outbreakupdates · X

Covid Autopsy

Jan 9, 2023 · 9 likes · 2 shares · 100,693 followers View post →
Blood brain barrier
@bbbpapers · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy https://t.co/xq0pjM7toA

Jan 8, 2023 · 773 followers View post →
jmankin
@jmankin · X

COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy https://t.co/fOMRYzyS7T

Jan 8, 2023 · 159 followers View post →