The discussions reflect moderate engagement with the article, highlighting key points like the variability in cough incidence among different ACE inhibitors and management strategies, often using tone that suggests curiosity rather than controversy or excitement. For example, mentions of the clinical implications and references to review articles indicate basic interest, but the tone remains relatively subdued, leading to a neutral overall impact.
AgreementNeither agree nor disagree
The discussions do not strongly agree or disagree, but briefly acknowledge the article and related studies.
InterestModerate interest
Posts show mild curiosity, referencing the topic and its clinical relevance.
EngagementModerate engagement
Participants engage by mentioning specific mechanisms, drug differences, or clinical applications, but without deep analysis.
ImpactNeutral impact
Overall, the discussions indicate limited immediate influence, mainly sharing summaries and opinions without pushing major changes.
Abstract in brief
ACE inhibitors (ACEi) are effective in improving survival and reducing major cardiovascular events, but they can cause a dry cough in some patients due to their mechanism of action involving angiotensin II and bradykinin.
The incidence of ACEi-related cough varies widely depending on the specific drug, study data, and patient population, with some medications like perindopril showing lower cough rates; real-world studies also report lower incidences than clinical trials.
To manage ACEi-induced cough, doctors often switch patients to angiotensin receptor blockers or perform a challenge-rechallenge test to see if reintroducing an ACEi causes symptoms; this approach helps avoid unnecessary discontinuation and allows patients to continue beneficial therapy.
Feb 9, 2023 · 18 likes · 2 shares · 1,845 followersView post →
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Sergio Moreno M
@Serginho1409 · X
Review Article
Pathophysiology of cough with angiotensin-converting enzyme inhibitors:
How to explain within-class differences? https://t.co/cJeSIcHM2R #tos #cough #IECA #CardioEd #MedEd
Jan 13, 2023 · 2 likes · 2,709 followersView post →
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ぽん@
@pharma_pon · X
アンギオテンシン変換酵素阻害剤による咳の病態生理：クラス内の違いをどう説明するか？
Pathophysiology of cough with angiotensin-converting enzyme inhibitors: How to explain within-class differences? https://t.co/Y25Fosgdnr
This video explores the mechanisms behind cough caused by ACE inhibitors such as captopril and enalapril, emphasizing how differences among drugs influence cough incidence and management options, including switching…
This video discusses a case of amiodarone-induced interstitial pneumonitis, highlighting clinical features, diagnosis, and management strategies for this serious adverse effect.
Feb 9, 2023 · 18 likes · 2 shares · 1,845 followersView post →
ぽ
ぽん@
@pharma_pon · X
アンギオテンシン変換酵素阻害剤による咳の病態生理：クラス内の違いをどう説明するか？
Pathophysiology of cough with angiotensin-converting enzyme inhibitors: How to explain within-class differences? https://t.co/Y25Fosgdnr
Review Article
Pathophysiology of cough with angiotensin-converting enzyme inhibitors:
How to explain within-class differences? https://t.co/cJeSIcHM2R #tos #cough #IECA #CardioEd #MedEd
Jan 13, 2023 · 2 likes · 2,709 followersView post →
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