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Nat Commun January 2023 PMID 36635284

Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5.

Hung Fu Tseng, Bradley K Ackerson, Katia J Bruxvoort, Lina S Sy, Julia E Tubert, Gina S Lee, Jennifer H Ku, Ana Florea, Yi Luo, Sijia Qiu, Soon Kyu Choi, Harpreet S Takhar, Michael Aragones, Yamuna D Paila, Scott Chavers

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Mentions

7
Peak: 2 in Jan 2023
across 3 sources since Jan 2023

Extended reach

6,960
potential audience

Total likes

8

Video views

17

Mentions per month

Jan 2023 – May 2023

Where it's discussed

  • News4 articles
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  • YouTube1 videos

AI synopsis

What people are saying

Discussions frequently mention the study’s focus on reduced immunity over time and the need for booster shots, with words like 'waning protection' and 'urgent need' indicating concern and engagement. The tone suggests curiosity and seriousness, emphasizing the importance of ongoing vaccination efforts based on the data presented.

AgreementModerate agreement

Most social discussions acknowledge the study's findings about waning vaccine effectiveness against newer Omicron variants, showing general support.

InterestHigh interest

The posts display high interest due to concern about vaccine efficacy and discussions around booster doses.

EngagementModerate engagement

Participants actively analyze implications, referencing data like protection decline after third doses and the need for updated boosters.

ImpactModerate impact

The discourse reflects a moderate recognition of the research’s importance for public health policy and vaccination strategies.

Abstract in brief

  • * The study, including over 123,000 individuals, finds that while three doses of the mRNA-1273 vaccine provide strong initial protection against infections, effectiveness diminishes quickly for newer subvariants like BA.2.12.1, BA.4, and BA.5 after the third dose.
  • * Hospitalization protection remains high with three doses but shows variability; four doses boost effectiveness but still drop significantly after a few months, indicating a need for evaluation of updated booster shots.
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