Aging Cell February 2023 PMID 36637079

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age.

Md Torikul Islam, Eric Tuday, Shanena Allen, John Kim, Daniel W Trott, William L Holland, Anthony J Donato, Lisa A Lesniewski

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Mentions

Peak: 20 in Jan 2023

across 5 sources since Jan 2023

Extended reach

195,204

potential audience

Total likes

2,289

Video views

69,114

Mentions per month

Jan 2023 – Aug 2024

Where it's discussed

X / Twitter26 posts
News6 articles
Blogs3 articles
YouTube2 videos
Reddit2 posts

AI synopsis

What people are saying

Discussions strongly focus on the importance of the findings, with many emphasize how senolytic drugs like dasatinib and quercetin could potentially revolutionize aging treatments. Their tone is enthusiastic and supportive, using words like 'great,' 'excellent,' and 'hot off the press,' which highlight a positive perception of the research's significance and potential impact in advancing aging therapies.

AgreementStrong agreement

Most discussions strongly endorse the findings, with many posts emphasizing the promising potential of senolytic drugs in aging research.

InterestHigh interest

The enthusiasm and repeated mentions suggest that colleagues find this research highly relevant and exciting, especially with phrases like 'great research article' and 'hot off the press.'

EngagementModerate engagement

Posts show some deep engagement through sharing specific article titles and expressing personal excitement about the study, but the tone remains mostly informational rather than critical.

ImpactHigh impact

The frequent reference to the significance of the research and calls to consider its implications indicate a perception of high impact in aging and metabolic health fields.

Abstract in brief

Senolytic drugs dasatinib and quercetin (DQ) reduce aging-related cell senescence and inflammation in fat tissue, leading to improved metabolic health in older mice.
DQ treatment decreased senescence markers and proinflammatory genes in adipose tissue, as well as reducing immune cell infiltration, but had limited effects on liver and muscle tissue.
Overall, DQ improved blood glucose regulation, lowered blood fats, and reduced liver glucose production, suggesting potential for therapies targeting age-related metabolic diseases.

Read the full abstract

All mentions

Senolytic Drugs Reduce Aging-related Cell Aging and Improve Metabolic Health

Senolytic drugs dasatinib and quercetin reduce cell senescence and inflammation in fat tissue of older mice, leading to improved metabolic functions such as blood glucose regulation and lowered blood fats.

Physionic · Nov 29, 2023 68,790 views

Senolytic Drugs Improve Metabolic Health in Aging Mice

Senolytic drugs dasatinib and quercetin reduce cell senescence and inflammation in fat tissue, enhancing metabolic functions such as blood glucose regulation and lowering blood fats in old mice.

吉米思想所 · Apr 30, 2024 324 views

Dr Richard Palmquist

@DrRPalmquist · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://t.co/YM9ndjSfjw

Aug 17, 2024 · 4,734 followers View post →

Immorta Bio

@ImmortaBio · X

Senolytics can prevent #inflammation made by aged fat tissue #immortabio https://t.co/k3meifyGW8

May 13, 2024 · 813 followers View post →

Elliot S'mon

@vvordsmyth · X

RT @DrPalmquist: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old…

Oct 2, 2023 · 2 shares · 2,563 followers View post →

Madrynha2024

@madrynha2012 · X

RT @DrPalmquist: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old…

Oct 1, 2023 · 2 shares · 3,205 followers View post →

DrRPalmquist

@DrPalmquist · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://t.co/mTzMlDRn1M

Oct 1, 2023 · 3 likes · 2 shares · 3,166 followers View post →

Advanced Biology

@Adv_Biology · X

Checkout this great Research Article from Aging Cell, entitled 'Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age' Click for more! #Wiley #AcademicChatter #AcademicTwitter https://t.co/lSPomWFwJq

Feb 16, 2023 · 635 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 25, 2023 · 4 shares · 881 followers View post →

Rubén Martínez

@EldarSilver · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 25, 2023 · 4 shares · 1,881 followers View post →

Lisa Vlad

@LisaVlad2 · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 25, 2023 · 4 shares · 107 followers View post →

(((Phroexus)))

@phroex · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 25, 2023 · 4 shares · 2,779 followers View post →

Agingdoc

@agingdoc1 · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://t.co/fDYEIXKrd5 @AgingCell https://t.co/i4W2n9u5pd

Jan 25, 2023 · 12 likes · 4 shares · 41,781 followers View post →

Orlando_uy

@Orlando_uy · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://t.co/DgKsGnqaS6

Jan 23, 2023 · 694 followers View post →

The ReNeural Project

@ReNeural · X

RT @MattYousefzadeh: https://t.co/OIQ7M2vE1b

Jan 22, 2023 · 1 share · 430 followers View post →

Matt Yousefzadeh

@MattYousefzadeh · X

https://t.co/OIQ7M2vE1b

Jan 21, 2023 · 21 likes · 1 share · 4,791 followers View post →

Andreea Nitescu RD MSc

@AndreeaNRD · X

This excellent paper was published Jan 2023 in @AgingCell, titled "Senolytic drugs, #dasatinib and #quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age"

Jan 17, 2023 · 2 likes · 1,304 followers View post →

Orlando_uy

@Orlando_uy · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. https://t.co/gSByf8Qxll

Jan 16, 2023 · 1 like · 694 followers View post →

UofU3i

@UofU3i · X

New 3i Investigator Article Alert!! Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://t.co/xCXiZAv4jM

Jan 14, 2023 · 1,179 followers View post →

Manuel Vazquez V

@ManuelVVidaurre · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 14, 2023 · 7 shares · 278 followers View post →

Imperator of Antarctica

@IndolentCoward · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 14, 2023 · 7 shares · 255 followers View post →

DrRPalmquist

@DrPalmquist · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 14, 2023 · 7 shares · 3,166 followers View post →

Sivaprakasam Chinnarasu, PhD

@sivabdubio · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 14, 2023 · 7 shares · 101 followers View post →

SoL

@We_rgreening · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 13, 2023 · 7 shares · 911 followers View post →

AgingResearch

@TheAgingField · X

RT @agingdoc1: Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old ag…

Jan 13, 2023 · 7 shares · 5,263 followers View post →

Agingdoc

@agingdoc1 · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age

Jan 13, 2023 · 40 likes · 7 shares · 41,781 followers View post →

Md Torikul Islam

@MTIslam_ · X

Hot off the press. A study that was so much fun to work on. https://t.co/FPEVnzLNvs

Jan 13, 2023 · 3 likes · 95 followers View post →

Adipose Papers

@adipose_papers · X

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age https://t.co/VSfESZ6qtj https://t.co/KceuAiJX3P

Jan 13, 2023 · 2,449 followers View post →

Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Senolytic Drugs Reduce Aging-related Cell Aging and Improve Metabolic Health

Senolytic Drugs Improve Metabolic Health in Aging Mice