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World Psychiatry February 2023 PMID 36640404

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications.

Ole A Andreassen, Guy F L Hindley, Oleksandr Frei, Olav B Smeland

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Mentions

68
Peak: 35 in Jan 2023
across 5 sources since Jan 2023

Extended reach

220,821
potential audience

Total likes

157

Video views

536

Mentions per month

Jan 2023 – Jul 2025

Where it's discussed

  • X / Twitter56 posts
  • News4 articles
  • Facebook3 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

This collection of discussions reflects a balanced view, with some commenters highlighting the modest heritability and predictive power of current genetic tools, as seen in remarks about SNP heritability being less than 10%, and polygenic risk scores explaining only small percentages of disease variance. The tone varies from skeptical to cautiously optimistic, emphasizing scientific challenges but also acknowledging ongoing progress, exemplified by references to recent reviews and technical terms, which demonstrate engagement with complex research findings.

AgreementNeither agree nor disagree

Discussions show mixed opinions, with some expressing skepticism about the practical significance of genetic findings, while others acknowledge the scientific progress.

InterestModerate interest

Most posts demonstrate a curiosity about recent advances, but some dismiss the topic as overstated or limited in clinical use, indicating moderate engagement.

EngagementModerate engagement

Users reference specific research details, such as heritability estimates and polygenic risk scores, indicating active discussion and effort to understand complexities.

ImpactModerate impact

While many recognize ongoing challenges and limitations, several posts suggest that the research could influence future understanding and treatment strategies, reflecting a cautious acknowledgment of potential impact.

Abstract in brief

  • Recent research in psychiatric genetics has shown that mental health disorders are influenced by thousands of common and rare genetic variants, and many individuals carry some genetic risk for these conditions.
  • These disorders often share genetic risk factors and exist on a continuum rather than as completely separate categories, implying that current diagnoses may need to be rethought to better reflect their biological links.
  • Although tools like polygenic risk scores are still developing and not yet used in clinical practice, future improvements could help personalize risk assessments and treatment strategies based on an individual's genetic profile.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Guy Hindley
@guyhindley · X

Jan 17, 2023 · 48 likes · 16 shares · 134 followers View post →
Nature Mental Health
@NatMentHealth · X

What is the contribution of genetics to precision #Psychiatry❓

Jan 18, 2023 · 23 likes · 7 shares · 5,211 followers View post →
Olav Smeland
@olavsmeland · X

Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privilege to write with @oleaandreassen, @guyhindley and @FreiOleksandr. https://t.co/JqkXvA0LkJ

Jan 16, 2023 · 19 likes · 5 shares · 289 followers View post →
Jay Joseph @jayjoseph22.bsky.social
@jayjoseph22 · X

The only thing that psychiatric genetic researchers have discovered in the past 50 years is genetic fool’s gold, because that’s all there is to discover. https://t.co/R8xeZDvxRY

May 12, 2023 · 17 likes · 4 shares · 3,438 followers View post →
Jesus Ramirez-Bermudez
@JRBneuropsiq · X

@StevePittelli @awaisaftab Instead of consensus, scientific evidence shows that the genetics of psych disorders is heterogenous -some disorders have higher risks as compared to others. The heritability estimate of depression is among the lowest; schizophrenia is higher https://t.co/vuxnYnWFe8

Mar 16, 2023 · 14 likes · 1 share · 31,245 followers View post →
Radoslaw Stupak
@RadoslawStupak · X

a good summary of the current state of genetic studies in psychiatry (if you skip all the standard and never (to be) fulfilled promises about future applications). https://t.co/q8CnU6AbTh

May 12, 2023 · 10 likes · 3 shares · 1,160 followers View post →

All mentions

luca
@luca64866738957 · X

@7avol1 @Boredandboring4 doi: 10.1002/wps.21034 La genetica psichiatrica sta cercando e trovando le precondizioni biologiche per diverse patologie. Lo ha fatto con le più gravi e lo farà per le meno gravi. Attenti a ignorare la biologia. Questo non significa tralasciare l'aspetto socioeconomico.

Jul 19, 2025 · 2 likes · 52 followers View post →
Radoslaw Stupak
@RadoslawStupak · X

@DrEvgenyLegedin Despite this success, the independent significant genetic variants still explain less than 10% of the SNP-heritability of schizophrenia" https://t.co/q8CnU6AbTh

Jun 18, 2024 · 1 like · 1,160 followers View post →
Diego Forero MD, PhD
@daforerog · X

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications https://t.co/RYUtCO4CPW

Apr 29, 2024 · 1,596 followers View post →
Jesus Ramirez-Bermudez
@JRBneuropsiq · X

@StevePittelli @GeorgeKirov1 You only expressed your suspicions regarding measurment bias, but you didn't give a reasonable explanation for why the twins should present a psychopatyhological pattern "resembling schizophrenia". Regarding GWAS, SNP based heritability is near 25% (https://t.co/vuxnYnWFe8) https://t.co/xXGKZ3MFiq

Mar 2, 2024 · 1 like · 31,245 followers View post →
Dr. Saúl Neuropsiquiatra (anti medX)
@DrPsiquiatraMx · X

@leafs_s "average life expectancy of people w severe mental illness is 10 years shorter with the excess mortality due to both physical health causes, particularly cardiovascular disease and mental health-related causes, such as suicide" https://t.co/FnLP5Lv4h8

Jan 7, 2024 · 1 like · 857 followers View post →
Ash Paul
@pash22 · X

@dawso007 Here's a 2023 review by @olavsmeland et al "New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications" https://t.co/zcjWWEqkwj @SameiHuda https://t.co/8zGr5rJ6fC

Oct 29, 2023 · 32,258 followers View post →
Radoslaw Stupak
@RadoslawStupak · X

@pedipsych For schizophrenia, which possesses the most well-powered GWAS to date, the best performing PRS method explained just 8.5% of the variance in liability for the disease, falling to 7.3% when non-European ancestry cohorts were included" https://t.co/q8CnU6AbTh

Sep 19, 2023 · 1 like · 1,160 followers View post →
De Doos van Pandora
@DoosPandora · X

@coristus @GenXDutchess Misschien vind je dit artikel interessant? https://t.co/xghGAnKQIC

Jul 27, 2023 · 1 like · 402 followers View post →
James Barnes MSc., MA
@psychgeist52 · X

@NancyDoylePsych @peterkinderman @EtoileViolette If you are reffering to polygenic risk scores, they are very low for ADHD (lower than most that are already low). They are also non-sepcific. https://t.co/ohUmvOUm2w https://t.co/ODAbJUc5bQ

May 16, 2023 · 12,937 followers View post →
Nalits
@SecretBaboon · X

RT @jayjoseph22: The only thing that psychiatric genetic researchers have discovered in the past 50 years is genetic fool’s gold, because t…

May 13, 2023 · 4 shares · 368 followers View post →
RaceRealist
@Race__Realist · X

RT @jayjoseph22: The only thing that psychiatric genetic researchers have discovered in the past 50 years is genetic fool’s gold, because t…

May 12, 2023 · 4 shares · 4,207 followers View post →
Otto Krebs
@n_decufa · X

RT @jayjoseph22: The only thing that psychiatric genetic researchers have discovered in the past 50 years is genetic fool’s gold, because t…

May 12, 2023 · 4 shares · 76 followers View post →
Jay Joseph @jayjoseph22.bsky.social
@jayjoseph22 · X

The only thing that psychiatric genetic researchers have discovered in the past 50 years is genetic fool’s gold, because that’s all there is to discover. https://t.co/R8xeZDvxRY

May 12, 2023 · 17 likes · 4 shares · 3,438 followers View post →
moving to @drjacekdebiec.bsky.social
@DebiecJacek · X

RT @RadoslawStupak: a good summary of the current state of genetic studies in psychiatry (if you skip all the standard and never (to be) fu…

May 12, 2023 · 3 shares · 6,830 followers View post →
James Barnes MSc., MA
@psychgeist52 · X

RT @RadoslawStupak: a good summary of the current state of genetic studies in psychiatry (if you skip all the standard and never (to be) fu…

May 12, 2023 · 3 shares · 12,937 followers View post →
Piotr Żołędziewski
@PEdziewski · X

RT @RadoslawStupak: a good summary of the current state of genetic studies in psychiatry (if you skip all the standard and never (to be) fu…

May 12, 2023 · 3 shares · 264 followers View post →
Radoslaw Stupak
@RadoslawStupak · X

a good summary of the current state of genetic studies in psychiatry (if you skip all the standard and never (to be) fulfilled promises about future applications). https://t.co/q8CnU6AbTh

May 12, 2023 · 10 likes · 3 shares · 1,160 followers View post →
virgen ortega
@virgenortega3 · X

RT @JRBneuropsiq: @StevePittelli @awaisaftab Instead of consensus, scientific evidence shows that the genetics of psych disorders is hetero…

Mar 16, 2023 · 1 share · 14 followers View post →
Jesus Ramirez-Bermudez
@JRBneuropsiq · X

@StevePittelli @awaisaftab Instead of consensus, scientific evidence shows that the genetics of psych disorders is heterogenous -some disorders have higher risks as compared to others. The heritability estimate of depression is among the lowest; schizophrenia is higher https://t.co/vuxnYnWFe8

Mar 16, 2023 · 14 likes · 1 share · 31,245 followers View post →
Naz Karadag
@bnkaradag · X

RT @olavsmeland: Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privileg…

Feb 17, 2023 · 5 shares · 109 followers View post →
Naz Karadag
@bnkaradag · X

RT @guyhindley:

Feb 1, 2023 · 16 shares · 109 followers View post →
Poppy Grimes @pzg.bsky.social
@poppyzenzi · X

RT @NatMentHealth: What is the contribution of genetics to precision #Psychiatry❓

Jan 31, 2023 · 7 shares · 287 followers View post →
BeyondStigma
@BeyondStigma · X

RT @NatMentHealth: What is the contribution of genetics to precision #Psychiatry❓

Jan 20, 2023 · 7 shares · 807 followers View post →
LAGC-PsychiatricGenetics
@LAGCPsychGene · X

RT @PsychGenPapers: New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implication…

Jan 19, 2023 · 3 shares · 269 followers View post →
Amanda Goodhart
@NurseGoodhart · X

RT @NatMentHealth: What is the contribution of genetics to precision #Psychiatry❓

Jan 19, 2023 · 7 shares · 382 followers View post →
Thomas Wolfers
@ThomasWolfers · X

RT @guyhindley:

Jan 19, 2023 · 16 shares · 875 followers View post →
Olav Smeland
@olavsmeland · X

RT @NatMentHealth: What is the contribution of genetics to precision #Psychiatry❓

Jan 18, 2023 · 7 shares · 289 followers View post →
World Psychiatric Association (WPA) wpanet.org
@WPA_Psychiatry · X

RT @NatMentHealth: What is the contribution of genetics to precision #Psychiatry❓

Jan 18, 2023 · 7 shares · 10,199 followers View post →
Dan Quintana
@dsquintana · X

RT @NatMentHealth: What is the contribution of genetics to precision #Psychiatry❓

Jan 18, 2023 · 7 shares · 20,567 followers View post →
Nature Mental Health
@NatMentHealth · X

What is the contribution of genetics to precision #Psychiatry❓

Jan 18, 2023 · 23 likes · 7 shares · 5,211 followers View post →
Sandeep Karthikeyan
@sandeepkarthik3 · X

RT @guyhindley:

Jan 18, 2023 · 16 shares · 145 followers View post →
Jenny Moe
@moejenny · X

RT @guyhindley:

Jan 18, 2023 · 16 shares · 196 followers View post →
Magnus Seierstad
@MagnusSeierstad · X

RT @guyhindley:

Jan 18, 2023 · 16 shares · 89 followers View post →
Natalie Thomas
@Natalie24914765 · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 1,190 followers View post →
Ann-Marie de Lange
@AnnMariedeLange · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 709 followers View post →
Tim Hughes
@tzhughes · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 59 followers View post →
Rune Bøen
@runeboen · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 319 followers View post →
DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 1,470 followers View post →
dtorok
@TorokDora01 · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 50 followers View post →
Norment
@SFFNORMENT · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 1,093 followers View post →
Olav Smeland
@olavsmeland · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 289 followers View post →
Dr Samuel Chawner
@ChawnerSamuel · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 1,172 followers View post →
World Psychiatric Association (WPA) wpanet.org
@WPA_Psychiatry · X

RT @guyhindley:

Jan 17, 2023 · 16 shares · 10,199 followers View post →
Guy Hindley
@guyhindley · X

Jan 17, 2023 · 48 likes · 16 shares · 134 followers View post →
Jan Ivar Røssberg
@JanIvarRossberg · X

RT @olavsmeland: Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privileg…

Jan 17, 2023 · 5 shares · 1,284 followers View post →
SEPSM
@SEPsiq · X

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications - Andreassen - 2023 - World Psychiatry - Wiley Online Library https://t.co/b2vm8URlEB

Jan 16, 2023 · 3 likes · 5,677 followers View post →
Zh1peng
@zh1peng · X

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications https://t.co/KRSEat7QOc

Jan 16, 2023 · 3 likes · 68 followers View post →
Norment
@SFFNORMENT · X

RT @olavsmeland: Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privileg…

Jan 16, 2023 · 5 shares · 1,093 followers View post →
World Psychiatric Association (WPA) wpanet.org
@WPA_Psychiatry · X

RT @olavsmeland: Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privileg…

Jan 16, 2023 · 5 shares · 10,199 followers View post →
Ole Andreassen
@oleaandreassen · X

RT @olavsmeland: Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privileg…

Jan 16, 2023 · 5 shares · 741 followers View post →
Olav Smeland
@olavsmeland · X

Happy to share our recent review in World Psychiatry @WPA_Psychiatry on new insights into psychiatric genetics. A privilege to write with @oleaandreassen, @guyhindley and @FreiOleksandr. https://t.co/JqkXvA0LkJ

Jan 16, 2023 · 19 likes · 5 shares · 289 followers View post →
Chris Lo
@chrislowh · X

RT @PsychGenPapers: New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implication…

Jan 15, 2023 · 3 shares · 191 followers View post →
Tore Willy Lie
@twlrop · X

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications (2023) https://t.co/w7fjE985CG

Jan 15, 2023 · 1 like · 610 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @PsychGenPapers: New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implication…

Jan 14, 2023 · 3 shares · 378 followers View post →
Psychiatric Genomics Bot
@PsychGenPapers · X

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications https://t.co/MQDUO6z7xj

Jan 14, 2023 · 6 likes · 3 shares · 180 followers View post →
PRS papers
@PRS_pubmed · X

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications https://t.co/02rhYOwN7L

Jan 14, 2023 · 398 followers View post →