Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial.
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Jan 2023 – Jul 2025Where it's discussed
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What people are saying
Several discussions emphasize the FOxTROT trial's promising outcomes, such as mentions of improved disease control rates and reduced recurrence risks. Phrases like 'excellent results' and 'better disease control at 2 years' convey a tone of enthusiasm and urgency, strengthening the perception of the study's relevance and importance within the oncology community.
The discussions consistently express strong support for the findings, with multiple users highlighting the effectiveness of preoperative chemotherapy.
There is a high level of curiosity about the study's details and implications, as many participants ask questions and share resources related to the research.
Contributors delve deep into the study's methodology and results, often referencing the specific impacts of neoadjuvant chemotherapy on patient outcomes.
The overall sentiment is that the study has significant implications for cancer treatment, with discussions containing phrases like 'game changer' and 'transformative'.
Abstract in brief
- Neoadjuvant chemotherapy (NAC) for locally advanced colon cancer was tested to see if it offers benefits over standard postoperative treatment, with a focus on how it affects disease recurrence and surgical outcomes.
- In a study of 699 patients, those receiving 6 weeks of NAC before surgery showed improved rates of downstaging, tumor regression, and fewer cases of residual disease compared to the control group who had 24 weeks of chemotherapy after surgery.
- While NAC was found to be safe and effective in reducing postoperative complications, the addition of the drug panitumumab did not provide additional benefits, especially in patients with tumors that have specific genetic characteristics.
Top posts
Most liked on X and BlueskyPreoperative chemotherapy for operable #ColonCancer in the @FoxtrotStudy is safe and yields: ⬆️ histopathologic downstaging
Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actually need immunotherapy. Find out more: https://t.co/w5wr5KADCK Read the paper: https://t.co/wegcXAtvRl #SoMe4Surgery #ColonCancer #ColorectalSurgery https://t.co/xGsqJFMB2o
Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial. https://t.co/lutohxTwy2 #GI23 #ColonCancer @ASCO @JCO_ASCO https://t.co/fSf8cItgCB
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Neoadjuvant Chemotherapy's Role in Colon Cancer Treatment
This week, Dr. Jenny Seligmann, a Professor at the University of Leeds, discusses neoadjuvant chemotherapy for locally advanced colon cancer. We explore its benefits over standard treatments and the implications of the…
https://t.co/9vVBRpPRED
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Great post @JohnRTMonsonMD we are certainly treating more colon cancer patients using the @FoxtrotStudy protocol after excellent results at 2 years. Results are open access in @JCO_ASCO for those who have not seen it yet https://t.co/mbuZxf4SyM https://t.co/EiK3uynCsA
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Published in @JCO_ASCO, FOxTROT showed that six weeks of preoperative chemotherapy for operable colon cancer can be delivered safely and provides better 2-year disease control #ICTD2023 https://t.co/8P6KCnqqpq
@OncBrothers @CathyEngMD @OncoAlert @OncoJurdi @pashtoonkasi @SKamath_MD @GIcancerDoc @TumorBoardTues @RenoHemonc @BijoyTelivala @CCAlliance @ThanksCancer @manjuggm @dr_yakupergun @SyedMAhmedMDPhD @ArndtVogel @HosseinTaghiz11 @HemOncFellows @IbrahimSahinMD1 @Jcj84Jeremy Thanks for wonderful scheme! What do You think about pre-operative therapy of colon cancer? (I mean FOxTROT trial (https://t.co/fTx4Bzpz8R)
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
RT @escp_tweets: Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surg…
Response to neoadjuvant #chemotherapy will potentially be used as a marker to decide who needs adjuvant therapy after surgery. Read more about the FOxTROT Study at the #ESCP website: https://t.co/S49EgSVatB Or read the paper: https://t.co/4Hrnsm3Gn4 #ColonCancer #SoMe4Surgery https://t.co/qMgMio4NiE
RT @JenSeligmann:
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
RT @escp_tweets: Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actua…
Another benefit of the FOxTROT study is that we saw that patients with MMRd do not respond to neoadjuvant chemo, but actually need immunotherapy. Find out more: https://t.co/w5wr5KADCK Read the paper: https://t.co/wegcXAtvRl #SoMe4Surgery #ColonCancer #ColorectalSurgery https://t.co/xGsqJFMB2o
This RCT evaluated the impact of providing 6 weeks of neoadjuvant chemotherapy + 18 postoperatively instead of the standard 24 weeks of postoperative chemotherapy for those with locally advanced #ColonCancer @justinmaykel @KarimAlavi @TessAulet @PRSturrock https://t.co/NVdhWQlNBW
RT @CamilleLStewart: Amazing how much things change over time in surgical oncology! Colorectal friends, are your T3/T4 colon cancer pts get…
Amazing how much things change over time in surgical oncology! Colorectal friends, are your T3/T4 colon cancer pts getting pre-op chemo now? https://t.co/uBY4QI1FSm
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RT @gabe_a_brooks: FoxTROT is a great and highly pragmatic study. Shows that we don't always need new drugs to learn new things in cancer t…
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RT @gabe_a_brooks: FoxTROT is a great and highly pragmatic study. Shows that we don't always need new drugs to learn new things in cancer t…
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FoxTROT is a great and highly pragmatic study. Shows that we don't always need new drugs to learn new things in cancer treatment. New drugs are great, but I love to see new studies that unlock better ways to use old drugs. https://t.co/Av6B9QBqr5
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6 sem de QT preoperatoria c/oxaliplatino-fluoropirimidina para CA colon operable no aumenta morbilidad perioperatoria, reduciendo estadificación histopatológica y resecciones incompletas y mejor control a los 2 años #colon #cancer #QT https://t.co/1M8J0nvvHH
יתרון לטיפול אונקולוגי לפני ניתוח- כעת גם בסרטן מעי גס. הצהרה פרובוקטיבית לחברים מפיד רפואה: All T3-4 or N+ tumors should get neoadjuvant therapy regardless of their origin https://t.co/clqBJobTnx
It seems that all T3-4 or N+ tumors should get neoadjuvant regardless of their origin! https://t.co/TsmD55k6gu
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https://t.co/UzzRrUU0zz #Oncology
RT @JenSeligmann:
RT @JenSeligmann:
RT @EuroSurg: Exciting to see #FOxTROT 1 published: https://t.co/C2i4X6bnk3 #APOLLO collecting important data on: - how many acutely prese…
RT @FoxtrotStudy: Interested? Please do download and share the full paper!
RT @JCO_ASCO: Preoperative chemotherapy for operable #ColonCancer in the @FoxtrotStudy is safe and yields: ⬆️ histopathologic downstaging…
RT @JCO_ASCO: Preoperative chemotherapy for operable #ColonCancer in the @FoxtrotStudy is safe and yields: ⬆️ histopathologic downstaging…
RT @JCO_ASCO: Preoperative chemotherapy for operable #ColonCancer in the @FoxtrotStudy is safe and yields: ⬆️ histopathologic downstaging…
RT @JCO_ASCO: Preoperative chemotherapy for operable #ColonCancer in the @FoxtrotStudy is safe and yields: ⬆️ histopathologic downstaging…
Preoperative chemotherapy for operable #ColonCancer in the @FoxtrotStudy is safe and yields: ⬆️ histopathologic downstaging
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https://t.co/DDAzzarfne
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International RCT https://t.co/wtldq7RRBc What Do you think about it? What about EGFR Inhibition in RAS-wt preoperative? Interesting development of knowledge. Congratulations! @ArndtVogel
RT @Fredros_Inc: By splitting colon cancer patients’ chemotherapy into two parts — one delivered before surgery and one after it — European…
By splitting colon cancer patients’ chemotherapy into two parts — one delivered before surgery and one after it — European researchers reduced their risk of recurrence by 28% compared to patients who received all of their chemo after surgery. https://t.co/eVqII3YkDE
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7- Referans: https://t.co/FNMR8Na7JE
@JCO_ASCO #crcsm FOxTROT randomised between NAC (periop chemo) and standard adjuvant in T3-4N0-2M0 CRC 1,053 (41%) of 2,591 were randomized - granularity on what happened to the 59% who weren't randomized would be helpful to place this trial in context https://t.co/0oCWITauxQ
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RT @CancerWarwick: The primary results for #FOxTROT have been published. Preoperative chemotherapy for locally advanced colon cancer is wel…
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RT @polom_karol: #Preoperative Chemotherapy for Operable #ColonCancer: Mature Results of an International #RandomizedControlledTrial https:…
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Published Paper! The primary FOxTROT1 paper, "Preoperative chemotherapy for operable colon cancer: mature results of an international randomised controlled trial has been published. Check the paper on the JCO website at https://t.co/P3JUlOqYuV (Open-access, free-to-view).
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RT @polom_karol: #Preoperative Chemotherapy for Operable #ColonCancer: Mature Results of an International #RandomizedControlledTrial https:…
RT @JenSeligmann:
#Preoperative Chemotherapy for Operable #ColonCancer: Mature Results of an International #RandomizedControlledTrial https://t.co/vlXwuRwzgb @JCOGO_ASCO
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https://t.co/zr103v6VQu
RT @BhamCTU: FOxTROT-1 trial results have been released by @JCO_ASCO! ✅Pre-operative chemotherapy for locally advanced operable colon canc…
Better disease control at 2 years with neo adjuvant chemo for advanced colorectal cancer. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial | Journal of Clinical Oncology https://t.co/LSijN1HJub
RT @RMirnezami: Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https:/…
TW : Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized...: PRIOR PRESENTATIONPresented in part at the 2019 ASCO annual meeting, Chicago, IL, May 31-June 4, 2019.FOxTROT was funded by Cancer Research UK… https://t.co/w9z5AFR7nM
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial | Journal of Clinical Oncology https://t.co/kVWm1IeB2n
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial | Journal of Clinical Oncology https://t.co/nK5HferaQc
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial | Journal of Clinical Oncology https://t.co/tSm7KisGr3
RT @RyanNipp: Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial. https…
RT @RMirnezami: Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https:/…
RT @RMirnezami: Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https:/…
Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial https://t.co/QuAbgXB9Ac
RT @BhamCTU: FOxTROT-1 trial results have been released by @JCO_ASCO! ✅Pre-operative chemotherapy for locally advanced operable colon canc…
FOxTROT-1 trial results have been released by @JCO_ASCO! ✅Pre-operative chemotherapy for locally advanced operable colon cancer is safe ✅Improved histopathological & oncological outcomes ✅Reduced 2-year recurrence https://t.co/d5Due1ohJU
RT @RMirnezami: Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https:/…
RT @NIHR_GSU: You can now view our primary FOxTROT1 paper: "Preoperative chemotherapy for operable colon cancer: mature results of an inter…
RT @RMirnezami: Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https:/…
RT @RMirnezami: Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https:/…
Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial https://t.co/alnW7P3f2O
RT @RyanNipp: Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial. https…
RT @RyanNipp: Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial. https…
RT @RyanNipp: Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial. https…
Preoperative Chemotherapy for Operable Colon #Cancer: Mature Results of an International Randomized Controlled Trial. https://t.co/lutohxTwy2 #GI23 #ColonCancer @ASCO @JCO_ASCO https://t.co/fSf8cItgCB
RT @NIHR_GSU: You can now view our primary FOxTROT1 paper: "Preoperative chemotherapy for operable colon cancer: mature results of an inter…
Chemotherapy before #surgery cuts risk of #coloncancer returning, trial finds https://t.co/VkExLRiGaj https://t.co/ieT7UcQeXN
RT @NIHR_GSU: You can now view our primary FOxTROT1 paper: "Preoperative chemotherapy for operable colon cancer: mature results of an inter…
You can now view our primary FOxTROT1 paper: "Preoperative chemotherapy for operable colon cancer: mature results of an international randomised controlled trial" on the @ASCO website. You can view the paper via the below link: https://t.co/hkYjPGRUvB