Elife January 2023 PMID 36719070

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.

Abby Sarkar, Yinhua Jin, Brian C DeFelice, Catriona Y Logan, Yan Yang, Teni Anbarchian, Peng Wu, Maurizio Morri, Norma F Neff, Huy Nguyen, Eric Rulifson, Matthew Fish, Avi Gurion Kaye, Azalia M Martínez Jaimes, Roel Nusse

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Mentions

41
Peak: 29 in Feb 2023
across 4 sources since Feb 2023

Extended reach

1,164,572
potential audience

Total likes

61

Video views

35

Mentions per month

Feb 2023 – Aug 2023

Where it's discussed

  • X / Twitter31 posts
  • News6 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

Discussions about the publication frequently highlight how intermittent fasting can directly stimulate liver cell proliferation, with several posts emphasizing the role of signaling molecules like FGF15 and WNT. The tone oscillates between scientific curiosity and acknowledgment of the significance, using words such as 'demonstrates,' 'shows,' and 'indicates,' which underscore the perceived importance of the research. The choice of words suggests that the community sees this study as a meaningful contribution to understanding diet and tissue regeneration, although references to broader applications are limited.

AgreementModerate agreement

Most discussions express support or positive acknowledgment of the findings, emphasizing the biological mechanism and the significance of diet on liver regeneration.

InterestHigh interest

Posts demonstrate high curiosity, highlighting new insights into diet-induced liver growth and signaling pathways, suggesting active engagement.

EngagementModerate engagement

Several comments reference specific mechanisms like FGF15 and WNT signaling, indicating some users are delving into the scientific details, but overall interactions seem to share a surface-level understanding.

ImpactModerate impact

While the posts recognize the importance of the findings, they largely focus on its scientific novelty rather than broader implications, reflecting moderate perceived impact.

Abstract in brief

  • Intermittent fasting triggers quick hepatocyte (liver cell) growth in mice, helping restore liver size and function.
  • This proliferative response is driven by systemic FGF15 and local WNT signals, linking diet to liver cell regulation.
  • The findings challenge the idea that adult liver cells are mostly inactive, showing diet can influence liver cell regeneration even without injury.]

Top posts

Most liked on X and Bluesky
Phys.org
@physorg_com · X

#Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezhX https://t.co/yHGAyLUClZ

Feb 2, 2023 · 17 likes · 8 shares · 1,023,854 followers View post →
Agingdoc
@agingdoc1 · X

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver https://t.co/WyN2a2OZCj @eLifeSciences https://t.co/kIQ2psa9It

Feb 2, 2023 · 14 likes · 1 share · 41,340 followers View post →
Daniel J Drucker
@DanielJDrucker · X

The nutrient sensitive Hepatostat- #IntermittentFasting alters the homeostatic regenerative programme in the liver with fundamental implications for the use of murine models to study liver regeneration and cancer @eLife https://t.co/vicZu3o345 https://t.co/7HdptgpDUZ

Feb 5, 2023 · 10 likes · 3 shares · 34,099 followers View post →
htw
@heniek_htw · X

#IntermittentFasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver We show that a switch from ad libitum feeding to intermittent fasting (IF) promotes rapid hepatocyte proliferation. https://t.co/CL3h8bijvJ https://t.co/u4dW7ljckM

Feb 3, 2023 · 5 likes · 4 shares · 11,266 followers View post →
Cordoba Lab (Liver Lab)_UIC Diabetes Center
@Cordoba_Lab · X

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver https://t.co/4Yoy6VPn7l

Feb 4, 2023 · 5 likes · 576 followers View post →
Adam J Rose
@DrAJRose · X

Intermittent #fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse #liver https://t.co/YLX1wtzW8L

Feb 3, 2023 · 3 likes · 811 followers View post →

All mentions

the paper link
@the_paper_link · X

https://t.co/8hQhi3k8cr #prime Sarkar A, ..., Nusse R (Elife) __Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver__ https://t.co/vJKQTb3pgw

Aug 18, 2023 · 137 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Intermittent fasting spurs proliferation of liver cells in lab mice, study finds https://t.co/GbtC2CJDLI https://t.co/DNgEtE69g3 https://t.co/kcSFnenArv

Mar 16, 2023 · 93 followers View post →
D.Polychronopoulos
@dpolychr2 · X

RT @OchreBio: The #liver demonstrates amazing metabolic flexibility depending on nutrient availability. Here, intermittent fasting in mice…

Feb 22, 2023 · 1 share · 678 followers View post →
Ochre Bio
@OchreBio · X

The #liver demonstrates amazing metabolic flexibility depending on nutrient availability. Here, intermittent fasting in mice increased hepatocyte proliferation, demonstrating the influence of diet on #liverregeneration capacity. #TeamOchre #liverdisease https://t.co/jQILbztrs5

Feb 22, 2023 · 2 likes · 1 share · 782 followers View post →
Pere Joan Sala
@Fradbius · X

Després del dejuni, els hepatòcits proliferen per ajudar el fetge a recuperar la seva mida original (ratolins). Mecanisme via FGF15 i WNT https://t.co/LSGkZL9ed5 Sarkar et al., "1r exemple d'influència de la dieta en la proliferació d'hepatòcits adults " https://t.co/tpIGO9oeYL

Feb 20, 2023 · 250 followers View post →
Heather
@Freyazon · X

RT @czbiohub: In the first demonstration of diet-induced liver regeneration, a Biohub & @StanfordMed study shows that #IntermittentFasting…

Feb 7, 2023 · 2 shares · 466 followers View post →
Francesco Puzzo
@cicciopuz · X

RT @czbiohub: In the first demonstration of diet-induced liver regeneration, a Biohub & @StanfordMed study shows that #IntermittentFasting…

Feb 7, 2023 · 2 shares · 1,391 followers View post →
Chan Zuckerberg Biohub Network
@czbiohub · X

In the first demonstration of diet-induced liver regeneration, a Biohub & @StanfordMed study shows that #IntermittentFasting spurs rapid liver cell proliferation in mice. Read in @eLife: https://t.co/cDhcK7eDkk 2/5 https://t.co/daBOgOehCw

Feb 7, 2023 · 2 likes · 2 shares · 17,160 followers View post →
Lasker Foundation
@LaskerFDN · X

Intermittent #fasting (IF) induces remodeling in several tissues but its effect on the liver remains unknown—until now. Researchers find that in mice, IF leads to hepatocyte proliferation and that it requires FGF15-β-KLOTHO signaling. @abby_sarkar https://t.co/qrKhdBnOH9 https://t.co/OVEbhSUx3l

Feb 7, 2023 · 7,325 followers View post →
Stern Lab
@SternLabAZ · X

RT @DanielJDrucker: The nutrient sensitive Hepatostat- #IntermittentFasting alters the homeostatic regenerative programme in the liver with…

Feb 6, 2023 · 3 shares · 108 followers View post →
McLane Montgomery
@Mcmontgomery11 · X

RT @DanielJDrucker: The nutrient sensitive Hepatostat- #IntermittentFasting alters the homeostatic regenerative programme in the liver with…

Feb 6, 2023 · 3 shares · 256 followers View post →
Eve Beavers
@espacetimeCO · X

RT @DanielJDrucker: The nutrient sensitive Hepatostat- #IntermittentFasting alters the homeostatic regenerative programme in the liver with…

Feb 6, 2023 · 3 shares · 901 followers View post →
Christian Molina Aguilar
@Christian_moli_ · X

https://t.co/S9Up32nps5

Feb 5, 2023 · 1 like · 539 followers View post →
Daniel J Drucker
@DanielJDrucker · X

The nutrient sensitive Hepatostat- #IntermittentFasting alters the homeostatic regenerative programme in the liver with fundamental implications for the use of murine models to study liver regeneration and cancer @eLife https://t.co/vicZu3o345 https://t.co/7HdptgpDUZ

Feb 5, 2023 · 10 likes · 3 shares · 34,099 followers View post →
Cordoba Lab (Liver Lab)_UIC Diabetes Center
@Cordoba_Lab · X

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver https://t.co/4Yoy6VPn7l

Feb 4, 2023 · 5 likes · 576 followers View post →
Adam J Rose
@DrAJRose · X

Intermittent #fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse #liver https://t.co/YLX1wtzW8L

Feb 3, 2023 · 3 likes · 811 followers View post →
Bruno Ramos-Molina, PhD
@Brunorm84 · X

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver @eLife https://t.co/g1uQIbFuWN

Feb 3, 2023 · 2 likes · 6,434 followers View post →
Almighty Keto Diet
@KetoDiet365 · X

RT @heniek_htw: #IntermittentFasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver We show that a sw…

Feb 3, 2023 · 4 shares · 805 followers View post →
OpenSci Talk
@OpenSciTalk · X

RT @RobotRrid: RRIDs were included in the eLife paper "Intermittent fasting induces rapid hepatocyte prol…" (https://t.co/tebA2DBpRO). RRID…

Feb 3, 2023 · 1 share · 4,095 followers View post →
DIE with a T
@DIEwithaTFilm · X

RT @heniek_htw: #IntermittentFasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver We show that a sw…

Feb 3, 2023 · 4 shares · 612 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the eLife paper "Intermittent fasting induces rapid hepatocyte prol…" (https://t.co/tebA2DBpRO). RRIDs like this improve reproducibility in scientific research. #OpenScience #STMpublishing

Feb 3, 2023 · 1 share · 161 followers View post →
htw
@heniek_htw · X

#IntermittentFasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver We show that a switch from ad libitum feeding to intermittent fasting (IF) promotes rapid hepatocyte proliferation. https://t.co/CL3h8bijvJ https://t.co/u4dW7ljckM

Feb 3, 2023 · 5 likes · 4 shares · 11,266 followers View post →
Lucas Tafur
@structureltp · X

RT @agingdoc1: Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver https://t.co/WyN2a…

Feb 2, 2023 · 1 share · 284 followers View post →
Agingdoc
@agingdoc1 · X

Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver https://t.co/WyN2a2OZCj @eLifeSciences https://t.co/kIQ2psa9It

Feb 2, 2023 · 14 likes · 1 share · 41,340 followers View post →
serrgv
@serrgv · X

RT @physorg_com: #Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezh…

Feb 2, 2023 · 8 shares · 148 followers View post →
home of the land king Brennan Kelly Do-Pray as a C
@doprayasacareer · X

RT @physorg_com: #Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezh…

Feb 2, 2023 · 8 shares · 7 followers View post →
Lee Ann, Stands with bear and sleeps among bees
@LeeAnnFlint1 · X

RT @physorg_com: #Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezh…

Feb 2, 2023 · 8 shares · 4 followers View post →
Muktabh Mayank
@muktabh · X

RT @physorg_com: #Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezh…

Feb 2, 2023 · 8 shares · 1,425 followers View post →
Mr. Cauthers
@MrCauthers · X

RT @physorg_com: #Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezh…

Feb 2, 2023 · 8 shares · 129 followers View post →
Phys.org Biology
@physorg_biology · X

RT @physorg_com: #Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezh…

Feb 2, 2023 · 8 shares · 8,218 followers View post →
Phys.org
@physorg_com · X

#Intermittentfasting spurs proliferation of #livercells in lab mice, study finds @sumedicine @elife https://t.co/HDwhQuezhX https://t.co/yHGAyLUClZ

Feb 2, 2023 · 17 likes · 8 shares · 1,023,854 followers View post →