PubHawk
Microbiome January 2023 PMID 36721179

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation.

Xintong Wang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen

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Mentions

34
Peak: 6 in Nov 2023
across 5 sources since Feb 2023

Extended reach

161,433
potential audience

Total likes

47

Video views

222

Mentions per month

Feb 2023 – Sep 2025

Where it's discussed

  • X / Twitter27 posts
  • YouTube2 videos
  • Facebook2 posts
  • News2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

The general tone of the discussions reflects a strong recognition of the study’s importance, with phrases like 'protective effects' and 'altering gut microbes' conveying enthusiasm. Words like 'mellows' and mentions of mechanisms such as 'microbiota–gut–brain axis' demonstrate both interest and deep engagement, highlighting the perceived significance of the findings in advancing knowledge about sleep, gut health, and neuroprotection.

AgreementStrong agreement

Most posts positively highlight the study's findings, emphasizing melatonin's neuroprotective effects linked to gut metabolites, showing strong backing for the publication's conclusions.

InterestHigh interest

Posts use engaging phrases like 'melatonin mellows' and mention related topics like gut health and sleep, indicating high curiosity and relevance.

EngagementModerate engagement

Some discussions delve into mechanisms, such as the role of butyrate and microbial changes, demonstrating a moderate level of detailed engagement.

ImpactModerate impact

Posts suggest the research could influence future treatments or understanding of sleep and neurodegeneration, signaling perceived high potential impact.

Abstract in brief

  • Sleep deprivation causes memory problems and disrupts gut bacteria, leading to inflammation and brain cell damage.
  • Melatonin helps improve these issues by restoring healthy gut bacteria and reducing inflammation, partly through metabolites like butyrate.
  • The study shows that molecules produced by gut bacteria (like butyrate) are crucial in melatonin’s protective effects against brain damage caused by sleep loss.]
Read the full abstract

Top posts

Most liked on X and Bluesky
htw
@heniek_htw · X

Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the #microbiota–gut–#brain axis. https://t.co/6saOsciiSs https://t.co/rkfmWNwAPy

Nov 30, 2023 · 22 likes · 8 shares · 11,266 followers View post →
DrRPalmquist
@DrPalmquist · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation https://t.co/jZpk33GqaV

Jan 31, 2024 · 7 likes · 5 shares · 3,160 followers View post →
Shima Ghavimi
@ShimaghavimiMD · X

@john_damianosMD @drkeithsiau @IBS_Maastricht @jfcryan @penderslab @MujagicZlatan @labgas_kuleuven @DrvanTilburg @JohannahRuddy @Mo_Shiha #melatonin downregulates the levels of #Aeromonas & constituent LPS & upregulates the levels of Lachnospiraceae_NK4A136 & butyrate in the colon hence ⬇️ inflammatory response & neuronal apoptosis in the hippocampus via crosstalk https://t.co/SeEIzcvrjy

Sep 17, 2023 · 4 likes · 4,492 followers View post →
DrRPalmquist
@DrPalmquist · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation https://t.co/jZpk33GqaV

Feb 7, 2024 · 4 likes · 1 share · 3,160 followers View post →
Research Square
@researchsquare · X

Check out our latest Video Bytes enhancing researcher impact! https://t.co/Mpme6XOncr "Melatonin mellows sleep loss–induced cognitive impairment by altering gut microbes and metabolites" Click here: https://t.co/BjpNhmPWJD @MicrobiomeJ #WorldSleepDay #sleep #guthealth https://t.co/tytL0VkG5O

Mar 17, 2023 · 2 likes · 16,586 followers View post →
Microbiome Articles
@microbe_article · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep d... - Wang X et al. - https://t.co/41xGQr0KVj #microbiome

Feb 1, 2023 · 2 likes · 1 share · 7,153 followers View post →

All mentions

MCAS, PTSD and ME
@FatigueMe92484 · X

RT @DrPalmquist: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by slee…

Feb 7, 2024 · 1 share · 1,179 followers View post →
DrRPalmquist
@DrPalmquist · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation https://t.co/jZpk33GqaV

Feb 7, 2024 · 4 likes · 1 share · 3,160 followers View post →
Elżbieta Łącka
@AckaElzbie27741 · X

RT @DrPalmquist: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by slee…

Feb 1, 2024 · 5 shares · 349 followers View post →
Cynthia Jones
@balanced_way · X

RT @DrPalmquist: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by slee…

Feb 1, 2024 · 5 shares · 520 followers View post →
Suede Labs Intern(Johnny Suede)
@jasoncola1 · X

RT @DrPalmquist: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by slee…

Feb 1, 2024 · 5 shares · 34,049 followers View post →
J P Fanton
@HealthyFellow · X

RT @DrPalmquist: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by slee…

Feb 1, 2024 · 5 shares · 26,024 followers View post →
DrRPalmquist
@DrPalmquist · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation https://t.co/jZpk33GqaV

Jan 31, 2024 · 7 likes · 5 shares · 3,160 followers View post →
Jeffrey Gross, M.D.
@DrJeffreyGross · X

RT @heniek_htw: Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the…

Dec 1, 2023 · 8 shares · 47 followers View post →
GLASS_PhD
@joybeingfree99 · X

RT @heniek_htw: Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the…

Nov 30, 2023 · 8 shares · 6,644 followers View post →
Sandeep Challa
@SandeepChalla15 · X

RT @heniek_htw: Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the…

Nov 30, 2023 · 8 shares · 78 followers View post →
Andres Felipe
@Anferupu · X

RT @heniek_htw: Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the…

Nov 30, 2023 · 8 shares · 52 followers View post →
AngryPhDstudent❗️❗️❗️
@ONNESHA092 · X

RT @heniek_htw: Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the…

Nov 30, 2023 · 8 shares · 182 followers View post →
Madam Mitochondria
@Madam_Mito · X

RT @heniek_htw: Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the…

Nov 30, 2023 · 8 shares · 10,312 followers View post →
htw
@heniek_htw · X

Schematic diagram of the protective effects of #melatonin on #cognitive impairment caused by #sleep deprivation through the #microbiota–gut–#brain axis. https://t.co/6saOsciiSs https://t.co/rkfmWNwAPy

Nov 30, 2023 · 22 likes · 8 shares · 11,266 followers View post →
Orlando_uy
@Orlando_uy · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation. https://t.co/31pYlaLIuT

Sep 23, 2023 · 690 followers View post →
Shima Ghavimi
@ShimaghavimiMD · X

@john_damianosMD @drkeithsiau @IBS_Maastricht @jfcryan @penderslab @MujagicZlatan @labgas_kuleuven @DrvanTilburg @JohannahRuddy @Mo_Shiha #melatonin downregulates the levels of #Aeromonas & constituent LPS & upregulates the levels of Lachnospiraceae_NK4A136 & butyrate in the colon hence ⬇️ inflammatory response & neuronal apoptosis in the hippocampus via crosstalk https://t.co/SeEIzcvrjy

Sep 17, 2023 · 4 likes · 4,492 followers View post →
Nicholas (@ultimape) Perry
@ultimape.bsky.wovensoup.com · Bluesky

"Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation" [2023] microbiomejournal.biomedcentral.com/articles/10....

Sep 8, 2023 · 1 share View post →
Dr.Nadiah Saeed Alzahrani
@AlzahraniNadiah · X

⭕️دراسة مميزة عن التأثيرات الوقائية للميلاتونين على الضعف الإدراكي الناجم عن الحرمان من النوم من خلال محور الأمعاء والدماغ

Jul 29, 2023 · 1 like · 471 followers View post →
drjasonmccloskey
@drjmccloskey · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation | Microbiome | Full Text https://t.co/kKwWyyZpIw

Jun 27, 2023 · 81 followers View post →
Marita Ostos
@MaritaOstos · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation | Microbiome | Full Text https://t.co/DmzXqdJcwd

May 17, 2023 · 158 followers View post →
For health-promoting environments
@SilkeLeFay · X

@NeuroscienceNew #geriatrics #brain #health #dementia #Alzheimers #primaryhealthcare #aging Gut microbiome imbalance causes microglia overactivation, neuronal apoptosis in the hippocampus and cognitive decline. Adequate butyrate levels have a protective effect . https://t.co/YoQgbbUI0d l

May 12, 2023 · 1 like · 4,596 followers View post →
For health-promoting environments
@SilkeLeFay · X

#neurology #neuroscience #dementia #agedcare #Alzheimers #geriatrics #dietetics Gut microbiome imbalance causes microglia overactivation, neuronal apoptosis in the hippocampus and cognitive decline. Adequate butyrate levels have a protective effect. . https://t.co/YoQgbbUI0d

Mar 22, 2023 · 4,596 followers View post →
AJE: American Journal Experts
@journalexperts · X

Check out our latest Video Bytes enhancing researcher impact! https://t.co/UhyKcyG0rc "Melatonin mellows sleep loss–induced cognitive impairment by altering gut microbes and metabolites" Click here: https://t.co/Z09kYfkAnp @MicrobiomeJ #WorldSleepDay #sleep #guthealth https://t.co/MLhZp4AaZC

Mar 17, 2023 · 4,322 followers View post →
Research Square
@researchsquare · X

Check out our latest Video Bytes enhancing researcher impact! https://t.co/Mpme6XOncr "Melatonin mellows sleep loss–induced cognitive impairment by altering gut microbes and metabolites" Click here: https://t.co/BjpNhmPWJD @MicrobiomeJ #WorldSleepDay #sleep #guthealth https://t.co/tytL0VkG5O

Mar 17, 2023 · 2 likes · 16,586 followers View post →
Miranda
@Mir47605898 · X

RT @microbe_article: Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by…

Feb 2, 2023 · 1 share · 32 followers View post →
Microbiome
@MicrobiomeJ · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation https://t.co/xXadADokt0

Feb 1, 2023 · 1 like · 1 share · 20,363 followers View post →
FMT Articles & Papers
@fmtarticles · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation https://t.co/HWctvdSCwj

Feb 1, 2023 · 1 like · 475 followers View post →
Microbiome Articles
@microbe_article · X

Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep d... - Wang X et al. - https://t.co/41xGQr0KVj #microbiome

Feb 1, 2023 · 2 likes · 1 share · 7,153 followers View post →