Front Cardiovasc Med January 2023 PMID 36727029

Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis.

Deqiang Yuan, Jiapeng Chu, Hao Lin, Guoqi Zhu, Jun Qian, Yunan Yu, Tongqing Yao, Fan Ping, Fei Chen, Xuebo Liu

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Mentions

4
Peak: 2 in Nov 2024
across 3 sources since Jan 2023

Extended reach

2,856
potential audience

Total likes

5

Video views

104

Mentions per month

Jan 2023 – Nov 2024

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts
  • News1 articles

AI synopsis

What people are saying

Participants commonly mention the significance of homocysteine levels and their role in endothelial injury, using terms like 'potential breakthrough' and 'crucial understanding.' They discuss mechanisms and treatment prospects, reflecting a genuine interest and recognition of the work's importance, though the tone remains mostly analytical rather than emotionally driven.

AgreementModerate agreement

Most discussions acknowledge the importance of understanding homocysteine's role in cardiovascular health, indicating general support for the findings.

InterestModerate interest

Posts show a moderate level of curiosity, with participants exploring both the biochemical mechanisms and potential clinical implications.

EngagementModerate engagement

Comments include references to the detailed mechanisms and upcoming treatment strategies, demonstrating active engagement beyond surface-level reactions.

ImpactModerate impact

The discussions suggest that the research could influence future diagnostic and treatment approaches, highlighting a noteworthy potential impact.

Abstract in brief

  • Homocysteine (Hcy) is an amino acid involved in the conversion of methionine to cysteine, and when its levels exceed 15 mol/L, it is called hyperhomocysteinemia (HHcy), which is a risk factor for atherosclerosis (AS).
  • HHcy damages the vascular endothelium, impairing its function and contributing to the initiation and progression of AS and cardiovascular events, although the exact mechanisms are not fully understood.
  • The review discusses how Hcy causes endothelial injury and explores potential treatment strategies to reduce this damage, aiming to improve diagnosis and management of Hcy-related vascular diseases.]

Top posts

Most liked on X and Bluesky
Frontiers in Cardiovascular Medicine
@FrontCVMedicine · X

New Research: Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis: Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from methionine to cysteine. When the fasting… https://t.co/GdTinfV1kw #cardiovascular

Jan 18, 2023 · 2,743 followers View post →

All mentions

Frontiers in Cardiovascular Medicine
@FrontCVMedicine · X

New Research: Mechanism of homocysteine-mediated endothelial injury and its consequences for atherosclerosis: Homocysteine (Hcy) is an intermediate amino acid formed during the conversion from methionine to cysteine. When the fasting… https://t.co/GdTinfV1kw #cardiovascular

Jan 18, 2023 · 2,743 followers View post →
Vascular dementia From pathobiology to emerging perspectives ...
News

9, 1109445 https://doi.org/10.3389/ Wald, D.S., Law, M., Morris, J., K., 2002. Homocysteine and cardiovascular disease: fcvm.2022.1109445. evidence on ...

Dec 23, 2025 View →