Overall, the posts convey a positive attitude toward the study’s potential impact, with phrases like 'potential molecular mechanism' and interest in pathways such as longevity and inflammation reflecting curiosity and recognition of significance. Technical references and praise for authors indicate a moderate level of engagement that values advancing scientific understanding.
AgreementModerate agreement
Most discussions recognize the significance of the study, highlighting its potential to link metformin use with epigenetic mechanisms involving DNA methylation and aging.
InterestModerate interest
The posts indicate moderate interest, often emphasizing the novelty of the research and its implications for longevity and molecular biology.
EngagementModerate engagement
Although the discussions show some engagement through mentions of specific biological pathways like AMPK and inflammation, the tone remains generally informational rather than deeply analytical.
ImpactModerate impact
The discussions suggest the study may influence future aging research and pharmacological approaches, though many posts focus on acknowledging the publication rather than debating or expanding on its findings.
Abstract in brief
The study investigates how metformin, a common diabetes drug, might promote aging and longevity by causing changes in DNA methylation, an epigenetic process that can influence gene activity.
Researchers analyzed DNA methylation data from blood samples of patients with or without metformin use and found that metformin-related pathways, such as longevity, AMPK, and inflammation, were enriched, suggesting a potential link to aging processes.
While no specific DNA sites showed strong statistical significance, the findings hint that metformin could extend lifespan through epigenetic modifications and other biological mechanisms related to aging and inflammatory pathways.]
Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 19, 2024 · 25 likes · 5 shares · 6,693 followersView post →
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Agingdoc
@agingdoc1 · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro Marra, @GenShinozakiMD & collaborators
https://t.co/63Qktw58vt
@biorxivpreprint
Oct 24, 2022 · 21 likes · 4 shares · 43,747 followersView post →
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Agingdoc
@agingdoc1 · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
“This study may elucidate metformin’s potential role in longevity through epigenetic modifications…”
https://t.co/Mc3UbSnRyC
@AgingJrnl https://t.co/hxoOIYcl6k
Feb 22, 2023 · 14 likes · 7 shares · 43,747 followersView post →
AN
Aging Science News
@AgingBiology · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
https://t.co/QMpRshxNNq
Feb 24, 2023 · 8 likes · 3 shares · 31,454 followersView post →
B
bioRxiv
@biorxivpreprint · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity https://t.co/WmQmBp0sFy #bioRxiv
Oct 24, 2022 · 6 likes · 1 share · 138,282 followersView post →
AU
Aging-US
@AgingJrnl · X
Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview
#9: "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity"
DOI: https://t.co/GzJWhoXyUt https://t.co/u2qZdSmlbj
Feb 6, 2024 · 5 likes · 4,400 followersView post →
This study explores how metformin may influence aging and lifespan through changes in DNA methylation, an epigenetic process. DNA methylation data from patients suggests links to longevity, AMPK, and inflammation…
AgingUS published this research paper on metformin's potential in influencing aging and longevity through DNA methylation changes. The study explores epigenetic mechanisms, including pathways related to inflammation and…
@Gaby06870254 Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity - PubMed
https://t.co/I6PkT8jlH0
Apr 19, 2024 · 1 like · 3,411 followersView post →
Rᚱ
Rosa Roger - ᚱ ᛟ ᛊ ᚨ ᚱᛟᚷᛖᚱ
@ny_hro · X
RT @DrMacip: Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 20, 2024 · 5 shares · 415 followersView post →
SS
Sociedad SENESCEL
@SENESCEL · X
RT @DrMacip: Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 19, 2024 · 5 shares · 401 followersView post →
AU
Aging-US
@AgingJrnl · X
RT @DrMacip: Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 19, 2024 · 5 shares · 4,400 followersView post →
MS
Massip-Salcedo
@MassipMarta · X
RT @DrMacip: Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 19, 2024 · 5 shares · 734 followersView post →
UI
Un Llop de Flix II*Il
@ALBERTLLOP · X
RT @DrMacip: Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 19, 2024 · 5 shares · 1,498 followersView post →
SP
Salvador Macip, MD, PhD
@DrMacip · X
Proud to have our paper on CUDC-907 as a new senolytic as one of @AgingJrnl's Top 10 Papers in 2023 https://t.co/4WPb3WuQlh
Feb 19, 2024 · 25 likes · 5 shares · 6,693 followersView post →
JG
John Greene
@Greene_Thoughts · X
RT @AgingJrnl: Watch an #agingshort video of Aging's top 10 #papers in 2023, based on the number of times a DOI is successfully resolved (C…
Feb 17, 2024 · 1 share · 1,707 followersView post →
AU
Aging-US
@AgingJrnl · X
Watch an #agingshort video of Aging's top 10 #papers in 2023, based on the number of times a DOI is successfully resolved (Crossref data).
https://t.co/D6XfiHlBQZ
#aging #oa #research #publication #lifespan #healthspan #gerontology #longevity #countdown #list #top10 #youtube
Feb 15, 2024 · 1 share · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
Join us daily as we count down the 10 most popular Aging papers in 2023 (based on Crossref resolutions). #2023YearinReview
#9: "Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity"
DOI: https://t.co/GzJWhoXyUt https://t.co/u2qZdSmlbj
Feb 6, 2024 · 5 likes · 4,400 followersView post →
DK
Dr Khalid
@rauf_khalid · X
RT @agingdoc1: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
“This…
Oct 23, 2023 · 7 shares · 2,483 followersView post →
OU
Orlando_uy
@Orlando_uy · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity.
https://t.co/amKNZte8vY
Feb 24, 2023 · 1 share · 3,113 followersView post →
AN
Aging Science News
@AgingBiology · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
https://t.co/QMpRshxNNq
Feb 24, 2023 · 8 likes · 3 shares · 31,454 followersView post →
RS
Reddit Journal of Science
@rsciencejournal · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity (Feb 2023) https://t.co/zqczbl62Cm #science #medicine #metformin #use #history #dna
The data presented here support our hypothesis that epigenetics, especially DNA methylation, may be altered by metformin use and that such epigenetic processes potentially contribute to molecular mechanisms leading to longevity.
https://t.co/1jifEdnlpW
A new study shows how metformin use history influences genome-wide DNA methylation profile, a potential molecular mechanism for aging and longevity. #Aging #Metformin https://t.co/AFTPHVsiYG via @AgingJrnl
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity (H/T @outbreakupdates)
https://t.co/IKrXpzyqgv
Feb 23, 2023 · 3 likes · 8,206 followersView post →
NH
Nguyen An Hoang
@NguyenAnHoang4 · X
RT @agingdoc1: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
“This…
RT @agingdoc1: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro…
Feb 22, 2023 · 4 shares · 606 followersView post →
A
Agingdoc
@agingdoc1 · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
“This study may elucidate metformin’s potential role in longevity through epigenetic modifications…”
https://t.co/Mc3UbSnRyC
@AgingJrnl https://t.co/hxoOIYcl6k
Feb 22, 2023 · 14 likes · 7 shares · 43,747 followersView post →
MX
Medical Xpress
@physorg_health · X
Study: Metformin's impact on aging and longevity through DNA methylation https://t.co/OX01hnzL3p https://t.co/M6VDhrSAJ9
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
斯坦福大学Gen Shinozaki团队通过表观遗传分析发现了与二甲双胍作用机制相关的通路,如寿命、AMPK和炎症通路,确定了与谵妄相关的几种途径
https://t.co/PxQZYUMOb9
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
https://t.co/Mc3UbSnRyC
Now published @AgingJrnl
Feb 4, 2023 · 2 likes · 1 share · 43,747 followersView post →
GM
Gen Shinozaki, MD
@GenShinozakiMD · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity - PubMed https://t.co/X2v6gA2LFG
Feb 3, 2023 · 4 likes · 1 share · 2,066 followersView post →
PC
PsychiatryAI.com
@PsychiatryAIcom · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity: Aging (Albany NY). 2023 Feb 2;15. doi: 10.18632/aging.204498. Online ahead of print. ABSTRACT BACKGROUND: Metformin, a commonly… https://t.co/SjTJjHD0bb
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
美国爱荷华大学医学院Pedro Marra与斯坦福大学Gen Shinozaki研究了二甲双胍使用史和全基因组DNA甲基化概况,并概述了其有关衰老和长寿的潜在分子机制
https://t.co/oWttM5eGcs
RT @agingdoc1: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro…
Oct 24, 2022 · 4 shares · 130 followersView post →
GK
George Kolostoumpis
@gkolost · X
RT @biorxivpreprint: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity…
Oct 24, 2022 · 1 share · 2,083 followersView post →
S
Snowwe
@_neigewhite · X
RT @agingdoc1: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro…
Oct 24, 2022 · 4 shares · 179 followersView post →
NM
N. Moncada
@ChiguiMedicina · X
RT @agingdoc1: Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro…
Oct 24, 2022 · 4 shares · 274 followersView post →
A
Agingdoc
@agingdoc1 · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity
Pedro Marra, @GenShinozakiMD & collaborators
https://t.co/63Qktw58vt
@biorxivpreprint
Oct 24, 2022 · 21 likes · 4 shares · 43,747 followersView post →
GM
Gen Shinozaki, MD
@GenShinozakiMD · X
Our new preprint is out! First author Pedro Marra is a superstar undergraduate @uiowa, who has already co-authored 8 papers with me!
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity https://t.co/Hbc8UWShkl
Oct 24, 2022 · 4 likes · 2,066 followersView post →
BG
bioRxiv Genetics
@biorxiv_genetic · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity https://t.co/qTs0zTfpGi #biorxiv_genetic
Oct 24, 2022 · 1 like · 4,757 followersView post →
B
bioRxiv
@biorxivpreprint · X
Metformin use history and genome-wide DNA methylation profile: potential molecular mechanism for aging and longevity https://t.co/WmQmBp0sFy #bioRxiv
Oct 24, 2022 · 6 likes · 1 share · 138,282 followersView post →
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... aging and longevity (February 2023) https://doi.org/10.18632/aging. 204498 Metformin, a commonly prescribed anti-diabetic medication, has ...