Adv Sci (Weinh) April 2023 PMID 36737841

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy.

Kwang-Su Park, Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong, Arum Kim, Gang Greg Wang, Husnu Ümit Kaniskan, Jian Jin

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Peak: 8 in Feb 2023

across 2 sources since Nov 2022

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161,583

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Nov 2022 – Jul 2023

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AI synopsis

What people are saying

The discussions demonstrate enthusiasm for the research, with posts mentioning the innovative protein degradation method as a 'game changer' and emphasizing its potential for advancing cancer treatments. The tone and choice of words reveal a keen interest in the technique’s broader applications, illustrating a deep engagement with the study's implications and promising future impact.

AgreementModerate agreement

Most posts acknowledge the novelty and potential significance of the research, showing general support.

InterestHigh interest

Discussions reflect high curiosity about the new degradation strategy and its implications, indicating strong interest.

EngagementModerate engagement

Participants reference specific aspects of the method and its potential applications, suggesting active engagement.

ImpactHigh impact

Many posts highlight the potential of this approach for cancer therapy, emphasizing its anticipated high impact.

Abstract in brief

The study introduces MS147, a novel drug that selectively targets and degrades core components of the PRC1 complex, BMI1 and RING1B, by using a new "protein complex degradation" method involving the EED protein and VHL E3 ligase.
MS147 effectively reduces H2AK119ub levels and inhibits cancer cell proliferation, especially in cells that do not respond to traditional PRC2 inhibitors, highlighting its potential as a cancer therapeutic.
This research not only provides a new chemical tool to study PRC1's role in cancer but also demonstrates a broader strategy for targeting and degrading specific proteins within the human proteome.]

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Innovative Protein Complex Degrader Targets PRC1 Components in Cancer Therapy

The study introduces MS147, a novel drug that selectively targets and degrades core components of the PRC1 complex, BMI1 and RING1B, using a new protein complex degradation method involving the EED protein and VHL E3…

STEM RTCL TV · Jul 26, 2023 45 views

Pharmacological Sciences

@DPS_ISMMS · X

RT @TischCancer: New from Jian Jin, PhD, and colleagues: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Comp…

Feb 9, 2023 · 1 share · 83 followers View post →

The Tisch Cancer Institute

@TischCancer · X

New from Jian Jin, PhD, and colleagues: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/JYOEHNEUd7 @IcahnMountSinai

Feb 9, 2023 · 1 like · 1 share · 4,243 followers View post →

Xing Bengang_ Research Group @ NTU_SG

@Xing_Group_NTU · X

RT @Trankill34: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/cGetBW…

Feb 6, 2023 · 5 shares · 572 followers View post →

ステイサム研究員

@sutadon_tabetai · X

RT @Trankill34: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/cGetBW…

Feb 6, 2023 · 5 shares · 1,484 followers View post →

Frantz Fanon

@waweru · X

RT @Trankill34: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/cGetBW…

Feb 6, 2023 · 5 shares · 8,002 followers View post →

Jong Yeon Hwang

@jy_hwang · X

RT @Trankill34: Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/cGetBW…

Feb 6, 2023 · 5 shares · 50 followers View post →

Guillaume Laconde

@Glaconde34 · X

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/cGetBWxgqn

Feb 6, 2023 · 19 likes · 5 shares · 4,814 followers View post →

Phage Papers

@Phage_Papers · X

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy https://t.co/0P48xTKYxa

Feb 4, 2023 · 647 followers View post →

Narkhyun Bae

@ghostbnh · X

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy https://t.co/m4JQRTaeGv

Nov 20, 2022 · 523 followers View post →

Biorxiv Reddit

@BiorxivReddit · X

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy https://t.co/Mezgza27b5

Nov 19, 2022 · 39 followers View post →

Ebazer Çimeken

@ebazer56 · X

RT @biorxivpreprint: Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy https://t.co/…

Nov 19, 2022 · 1 share · 4,092 followers View post →

bioRxiv

@biorxivpreprint · X

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy https://t.co/hhhct1TpLI #bioRxiv

Nov 19, 2022 · 4 likes · 1 share · 136,931 followers View post →

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Innovative Protein Complex Degrader Targets PRC1 Components in Cancer Therapy