Mol Oncol April 2023 PMID 36744875

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration.

Veronika Fedorova, Veronika Pospisilova, Tereza Vanova, Katerina Amruz Cerna, Pavel Abaffy, Jiri Sedmik, Jan Raska, Simona Vochyanova, Zuzana Matusova, Jana Houserova, Lukas Valihrach, Zdenek Hodny, Dasa Bohaciakova

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Mentions

Peak: 10 in Feb 2023

across 2 sources since Feb 2023

Extended reach

19,643

potential audience

Total likes

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116

Mentions per month

Feb 2023 – Oct 2024

Where it's discussed

X / Twitter13 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions highlight appreciation for the study’s contributions, such as including RRIDs for reproducibility and references to the model’s potential in cancer research, evidenced by phrases like 'wonderful study' and 'looking forward to next projects.' The tone is generally positive and collaborative, with words emphasizing support and continuation, which reflect a moderately strong agreement and interest in the research's implications.

AgreementModerate agreement

Most commenters express positive support, mentioning contributions and appreciation for the research, indicating overall agreement or approval.

InterestHigh interest

Discussions show high interest, with mentions of contributions and future collaborations, reflecting engagement with the topic's relevance and potential.

EngagementModerate engagement

Posts primarily share praise and remarks about the study's quality or reproducibility, suggesting moderate depth of involvement.

ImpactModerate impact

The collective tone hints at recognition of the model's significance and potential, though discussions are still mostly preliminary or supportive.

Abstract in brief

The study highlights the limitations of traditional 2D cell cultures in modeling glioblastoma, emphasizing the advantages of 3D cerebral organoids for preserving tumor heterogeneity and patient-specific features.
Researchers developed a glioblastoma-organoid (GLICO) coculture model using mature cerebral organoids to study tumor growth and migration, noting that extracellular matrix proteins accelerate these processes.
The GLICO model allows detailed visualization and quantification of tumor cell migration and can induce changes in gene expression, shifting glioblastoma cells toward proneural and classical subtypes, providing a more realistic in vitro system for studying the disease.]

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Glioblastoma and Cerebral Organoids: In Vitro Model Development and Analysis

This video discusses the development of a glioblastoma-organoid (GLICO) coculture model using cerebral organoids to study tumor growth, migration, and gene expression changes, offering a more realistic in vitro system…

Social RTCL TV · Jun 29, 2023 116 views

feras al battah

@BattahFera31175 · X

RT @LukasValihrach: Happy to contribute to this wonderful study “Glioblastoma and cerebral organoids: development and analysis of an in vit…

Oct 10, 2024 · 2 shares · 18 followers View post →

OpenSci Talk

@OpenSciTalk · X

RT @RobotRrid: The authors of "Glioblastoma and cerebral organoids: development a…" (https://t.co/x5T1AX6oGw) included RRIDs in their paper…

Apr 6, 2023 · 1 share · 4,087 followers View post →

RRID Robot

@RobotRrid · X

Apr 6, 2023 · 1 like · 1 share · 161 followers View post →

Aaron A Alli

@aaronallino · X

RT @MolOncology: Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration

Feb 25, 2023 · 5 shares · 638 followers View post →

International Clinical Research Center

@FNUSA_ICRC · X

RT @MolOncology: Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration

Feb 24, 2023 · 5 shares · 466 followers View post →

EANO

@EANOassociation · X

RT @MolOncology: Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration

Feb 24, 2023 · 5 shares · 4,283 followers View post →

Lukas Valihrach

@LukasValihrach · X

RT @MolOncology: Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration

Feb 24, 2023 · 5 shares · 3,425 followers View post →

Molecular Oncology

@MolOncology · X

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration

Feb 24, 2023 · 20 likes · 5 shares · 2,200 followers View post →

CancerLinks 

@CancerLinks · X

RT @EARA_IE: #Glioblastoma #Metastasis #CancerResearch #CerebralOrganoids #3DModels #3Rs #Replacement https://t.co/KvLHZEzW5N

Feb 20, 2023 · 1 share · 97 followers View post →

EARA_IE

@EARA_IE · X

#Glioblastoma #Metastasis #CancerResearch #CerebralOrganoids #3DModels #3Rs #Replacement https://t.co/KvLHZEzW5N

Feb 20, 2023 · 1 like · 1 share · 383 followers View post →

Laboratory of Gene Expression

@labgenex · X

RT @LukasValihrach: Happy to contribute to this wonderful study “Glioblastoma and cerebral organoids: development and analysis of an in vit…

Feb 17, 2023 · 2 shares · 243 followers View post →

Lukas Valihrach

@LukasValihrach · X

Feb 17, 2023 · 10 likes · 2 shares · 3,425 followers View post →

HumanBrainDevelopment

@HumanBrainDeve1 · X

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration https://t.co/MzjRZQ8KfF

Feb 6, 2023 · 32 followers View post →

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration.

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Glioblastoma and Cerebral Organoids: In Vitro Model Development and Analysis