Nat Commun February 2023 PMID 36746968

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model.

L Tanner, A B Single, R K V Bhongir, M Heusel, T Mohanty, C A Q Karlsson, L Pan, C-M Clausson, J Bergwik, K Wang, C K Andersson, R M Oommen, J S Erjefält, J Malmström, O Wallner

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Mentions

Peak: 4 in Feb 2023

across 3 sources since Feb 2021

Extended reach

141,735

potential audience

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Feb 2021 – May 2023

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Facebook2 posts
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AI synopsis

What people are saying

The posts reflect a general interest in the research's promising approach but display a cautious tone, exemplified by remarks like 'interesting approach, no hydroxyproline readout though?' which shows curiosity mixed with critique. The tone and mention of ongoing research highlight a tentative yet optimistic view about its future impact.

AgreementNeither agree nor disagree

Most discussions acknowledge the significance of the research but do not express strong agreement or disagreement with its findings.

InterestModerate interest

There is mild curiosity about the approach, especially with comments noting the novelty and potential, but some questions remain, such as the absence of certain readouts.

EngagementNeutral engagement

Comments tend to be brief, with some referencing the methodology or significance, but few delve deeply into implications or critique.

ImpactNeutral impact

The overall tone is cautious; users recognize the potential impact of OGG1 inhibition but note that it is still early-stage research requiring further validation.

Abstract in brief

The study highlights that targeting the DNA repair enzyme OGG1 with small molecules like TH5487 can reduce lung inflammation and fibrosis in mice, suggesting a new potential treatment for idiopathic pulmonary fibrosis (IPF).
OGG1 plays a significant role in inflammation and cell processes related to lung fibrosis, and inhibiting it with specific drugs can slow disease progression by decreasing fibroblast activity and inflammatory responses.
The findings support further research into OGG1 inhibitors like TH5487 as promising therapeutic options for IPF, although human clinical trials are still needed to confirm their effectiveness.]

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All mentions

OGG1 Inhibition Reduces Pulmonary Inflammation and Fibrosis in Mice

Targeting the DNA repair enzyme OGG1 with small molecules like TH5487 can reduce lung inflammation and fibrosis in mice, offering a potential new treatment for idiopathic pulmonary fibrosis.

STEM RTCL TV · May 22, 2023 54 views

biophotonicat

@biophotonicat · X

RT @biophotonicat: Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis mo…

Feb 21, 2023 · 1 share · 1,529 followers View post →

the paper link

@the_paper_link · X

Feb 8, 2023 · 137 followers View post →

LiteratureFeed

@LiteratureFeed · X

NER: Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model https://t.co/hdr7bg65h8

Feb 8, 2023 · 156 followers View post →

biophotonicat

@biophotonicat · X

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model (relevance: 52%) https://t.co/U1GEc0WehC #biophotonics #biomedicaloptics

Feb 6, 2023 · 1 share · 1,529 followers View post →

George Vlasuk

@GVlasuk · X

Interesting approach, no hydroxyproline readout though?-Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis https://t.co/j9FaU5ILps

Feb 28, 2021 · 1,395 followers View post →

bioRxiv

@biorxivpreprint · X

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis https://t.co/0W9bq3bha1 #bioRxiv

Feb 28, 2021 · 1 like · 136,931 followers View post →