J Obes Metab Syndr March 2023 PMID 36750526

Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management.

Rachel Sinha, Dimitris Papamargaritis, Jack A Sargeant, Melanie J Davies

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Peak: 46 in Apr 2023

across 3 sources since Apr 2023

Extended reach

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838

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52,118

Mentions per month

Apr 2023 – Sep 2025

Where it's discussed

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YouTube2 videos

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What people are saying

Several discussions mention the mechanism of action and results from the SURPASS trials, highlighting words like 'new era' and 'great paper' which suggest excitement about the potential of tirzepatide. The tone of these posts conveys enthusiasm and importance, particularly when discussing its dual action as a treatment option, which adds to the overall positive sentiment and awareness of the drug's significance.

AgreementModerate agreement

Most discussions express positive sentiments about the publication, indicating support for the findings.

InterestHigh interest

There is a strong curiosity about the mechanisms and implications of tirzepatide, indicating high interest levels.

EngagementModerate engagement

While some posts show deeper inquiries into the implications, others remain more surface-level.

ImpactHigh impact

Many participants believe this research could greatly influence treatment options for diabetes and obesity.

Abstract in brief

The combination of GLP-1 and GIP hormones aims to boost glucose control and weight loss, leading to the development of tirzepatide, the first approved dual GLP-1/GIP receptor co-agonist for type 2 diabetes (T2DM) treatment.
The SURPASS trials demonstrated that once-weekly tirzepatide doses significantly reduced blood sugar levels and body weight while improving various cardiometabolic risk factors over 104 weeks, showing better results than other diabetes medications.
Additionally, in non-diabetic individuals, tirzepatide led to notable weight loss reductions, highlighting its potential as a new option for managing T2DM and obesity through dual hormone action.

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Tirzepatide: A New Solution for Type 2 Diabetes and Obesity

Explore the efficacy and safety of tirzepatide, the first dual GLP-1/GIP receptor co-agonist for type 2 diabetes management. The SURPASS trials showed significant reductions in blood sugar and body weight, making it a…

Tai-Lin (Irene) Lee · Aug 11, 2025 52,074 views

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MyDoctorWellness · Sep 12, 2025 44 views

Dimitris Papamargaritis

@ri_tis · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Feb 15, 2024 · 52 shares · 702 followers View post →

Eve Beavers of espacetimeNOT & espacetimeCO

@espacetimeCO · X

https://t.co/EZIwbshRYK this is awesome. on my MAC it took several tries to get it to download. why did "Big Pharma" decide to make these injectable weekly or bi-weekly medications? for the last 4 years, I have a "pet idea" of why some folks get type 2 diabetes first. the

Nov 20, 2023 · 898 followers View post →

Eve Beavers of espacetimeNOT & espacetimeCO

@espacetimeCO · X

https://t.co/JWPFFZ0332 it took some time to download this to view. I assure you, humans are not identical in responses to incretin hormones. We have differing kidney function, receptors, brain responses. putting meds out in injectable vials to last 1 week or 4 weeks? Big

Nov 20, 2023 · 1 share · 898 followers View post →

Paula

@pbatalhac · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Jun 17, 2023 · 52 shares · 38 followers View post →

Nia Luxton

@NiaALuxton · X

RT @sandybassin_md: Great paper summarizing the MOA and SURPASS trial results of #tirzepatide #Mounjaro by @ri_tis and co! #Endocrine #obes…

Jun 6, 2023 · 2 shares · 2,244 followers View post →

Dimitris Papamargaritis

@ri_tis · X

RT @sandybassin_md: Great paper summarizing the MOA and SURPASS trial results of #tirzepatide #Mounjaro by @ri_tis and co! #Endocrine #obes…

May 31, 2023 · 2 shares · 702 followers View post →

Sandy Bassin, MD

@sandybassin_md · X

Great paper summarizing the MOA and SURPASS trial results of #tirzepatide #Mounjaro by @ri_tis and co! #Endocrine #obesity #diabetes #endotwitter https://t.co/BFamHUdDfw https://t.co/wBop1sygOZ

May 31, 2023 · 5 likes · 2 shares · 69 followers View post →

Jhanira Alférez Condori

@AlferezJhanira · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

May 5, 2023 · 52 shares · 9 followers View post →

METAnetwork - Red Andaluza de EECC en Metabolismo

@RedMETAnetwork · X

May 2, 2023 · 300 followers View post →

Isa Navarro

@isanavarrox · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 28, 2023 · 52 shares · 219 followers View post →

mjcastillo

@mjcasmor · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 27, 2023 · 52 shares · 153 followers View post →

EndoCM Salud Metabólica

@EndoCMsalud · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 27, 2023 · 52 shares · 132 followers View post →

Susana Monereo

@SusanaMonereo · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 26, 2023 · 52 shares · 2,221 followers View post →

Sociedad Extremeña de Diabetes

@sediextremadura · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 26, 2023 · 52 shares · 292 followers View post →

Andres Ricaurte

@aricaurtegineco · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 26, 2023 · 52 shares · 188 followers View post →

Roberto Cortés

@Robercort182 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 26, 2023 · 52 shares · 50 followers View post →

ISLAND MED

@ISLANDMEDCLINIC · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 187 followers View post →

RSanchezEndo

@rsanherj · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 32 followers View post →

Javier T

@Javier_Toro_ · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 53 followers View post →

Juan M Guardia Baena

@jmguardiabaena · X

RT @SANCYDnutricion: Eficacia y seguridad de la tirzepatida en el manejo de la diabetes tipo 2 y la obesidad Efficacy and Safety of Tirzep…

Apr 25, 2023 · 1 share · 144 followers View post →

Ivan Quispe Marca. MD, EM

@Drivanqm · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 38 followers View post →

SANCYD

@SANCYDnutricion · X

Eficacia y seguridad de la tirzepatida en el manejo de la diabetes tipo 2 y la obesidad Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management https://t.co/ftfNnK0LXC

Apr 25, 2023 · 3 likes · 1 share · 3,022 followers View post →

Paula

@Paulazubi · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 19 followers View post →

METAnetwork - Red Andaluza de EECC en Metabolismo

@RedMETAnetwork · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 300 followers View post →

Norestense

@Rooney73029223 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 76 followers View post →

angeles nava

@angelnava76 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 25, 2023 · 52 shares · 65 followers View post →

Hector

@Hector63433971 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 45 followers View post →

ManuG

@Badu90390706 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 40 followers View post →

LUIS GARCIA CARRION

@LGARCIALSM · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 486 followers View post →

Fernando Vidal-Ostos De Lara

@drvidalostos · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 442 followers View post →

Jamie Wang

@jamiewang1228 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 10 followers View post →

Carlos Perez.

@perez_busso · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 129 followers View post →

Miguel Turégano

@tureyedro · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 814 followers View post →

Ana Zugasti

@ana_azugas · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 3,569 followers View post →

Guayacan Chiquito

@guayacanchiquit · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 345 followers View post →

Juan Daniel C.

@Juancho1789 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 353 followers View post →

EstiUgarte

@EstiUgarte · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 1,489 followers View post →

Alexis A.

@Alexis_arbra · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 220 followers View post →

Ezequiel Arranz

@Ezequie75156572 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 382 followers View post →

Juan Luis Alonso

@jalojer · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 1,419 followers View post →

INTERNAL MEDICINE

@medicinterna · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 2,462 followers View post →

Muhammad Tahir

@tauhair · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 239 followers View post →

Javierpa95

@javi95lol · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 99 followers View post →

Ed Márquez

@dremarquezr · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 2,855 followers View post →

Yacir Almeida

@Dryaciralmeida · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 59 followers View post →

Raúl San

@raulsan1978 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 415 followers View post →

Elena González Arnáiz

@ElenaGonzarnaiz · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 458 followers View post →

fausto heredia z.

@drfherediaz · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 4,356 followers View post →

gustavobecerra

@gustavo103026 · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 16 followers View post →

Dra. Erica Yama

@Ericayamitayama · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 97 followers View post →

Javier Escalada #Yoelijoendocrino

@fjavesc · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 3,625 followers View post →

Óscar Baro Pato

@baro_dr · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 924 followers View post →

Ángel León/@NCSDONALDPRESS

@NCSDONALDPRESS · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 3,331 followers View post →

Brayanentrenador

@Brayancoach · X

RT @CristobMorales: Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabet…

Apr 24, 2023 · 52 shares · 13 followers View post →

Cristobal Morales

@CristobMorales · X

Empezamos una nueva era con los CoAgonistas #LosPeptidosDelHambre : Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management

Apr 24, 2023 · 105 likes · 52 shares · 17,080 followers View post →

Efficacy and Safety of Tirzepatide in Type 2 Diabetes and Obesity Management.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Tirzepatide: A New Solution for Type 2 Diabetes and Obesity

Impact of 72-Hour Fasting on Brain Function and Health