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Cancer Med April 2023 PMID 36752185

Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients.

Marissa Z Powell, Kristin C Mara, Radhika Bansal, Matthew A Hathcock, Arushi Khurana, N Nora Bennani, Yucai Wang, Jonas Paludo, Jose Villasboas Bisneto, Stephen M Ansell, Patrick B Johnston, Yi Lin, Jason N Barreto

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Mentions

8
Peak: 2 in Feb 2023
across 4 sources since Feb 2023

Extended reach

416
potential audience

Total likes

1

Video views

39

Mentions per month

Feb 2023 – Aug 2023

Where it's discussed

  • News4 articles
  • X / Twitter2 posts
  • YouTube1 videos
  • TikTok1 posts

AI synopsis

What people are saying

Several posts acknowledge the limitations of procalcitonin levels in predicting bacterial infections in CAR T-cell therapy patients, such as noting its moderate predictive ability (AUC of 0.62), while others mention that all patients experienced CRS regardless of PCT results. The tone remains clinical and objective, reflecting cautious interest and recognition of the challenges in applying PCT as a biomarker in this context.

AgreementNeither agree nor disagree

Posts are somewhat neutral, with some recognizing the study's findings but not strongly endorsing or criticizing them.

InterestModerate interest

Discussions indicate a mild interest, as users are curious but do not deeply explore the topic.

EngagementNeutral engagement

Comments show minimal in-depth analysis, mostly summarizing or echoing the article's main points.

ImpactModerate impact

The conversations suggest the publication’s influence is moderate, prompting some consideration but not widespread debate.

Abstract in brief

  • The study investigates whether serum procalcitonin (PCT) levels can help distinguish bacterial infections from cytokine release syndrome (CRS) in patients undergoing CAR T-cell therapy, finding that PCT within 48 hours of fever onset is significantly associated with confirmed bacterial infections.
  • Elevated PCT levels had limited predictive ability, with an area under the curve (AUC) of 0.62, suggesting moderate accuracy in identifying bacterial infections among these patients.
  • All patients experienced CRS regardless of PCT levels, and broad-spectrum antibiotics were prescribed for similar durations whether bacterial infection was confirmed or not, indicating challenges in relying on PCT alone for infection management in this context.]
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Top posts

Most liked on X and Bluesky
ImmunotherapyPapers
@Immunotx_papers · X

Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients https://t.co/o1YWVkPvGR

Feb 17, 2023 · 247 followers View post →
ASP_Papers
@ASP_Papers · X

Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients https://t.co/SPV6SJtNNK https://t.co/nf6eN3NINw

Feb 8, 2023 · 80 followers View post →

All mentions

ImmunotherapyPapers
@Immunotx_papers · X

Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients https://t.co/o1YWVkPvGR

Feb 17, 2023 · 247 followers View post →
ASP_Papers
@ASP_Papers · X

Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients https://t.co/SPV6SJtNNK https://t.co/nf6eN3NINw

Feb 8, 2023 · 80 followers View post →
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