Adv Sci (Weinh) April 2023 PMID 36755192

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity.

Yingkai Sun, Juan Zhang, Jie Hong, Zhongyun Zhang, Peng Lu, Aibo Gao, Mengshan Ni, Zhiyin Zhang, Huanjie Yang, Juan Shen, Jieli Lu, Wenzhi Xue, Qianqian Lv, Yufang Bi, Yi Arial Zeng

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Peak: 2 in Feb 2023

across 3 sources since Feb 2023

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Feb 2023 – Jul 2023

Where it's discussed

News3 articles
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What people are saying

Overall, discussions demonstrate a high level of interest and moderate engagement, as posters comment on how RSPO1 influences fat burning and obesity, with language emphasizing its scientific importance, such as 'key mechanism' and 'potential target,' reflecting perceived impact and active engagement with the research.

AgreementModerate agreement

Most discussions acknowledge the significance of RSPO1's role in obesity, with some posts explicitly supporting the study's findings.

InterestHigh interest

The topic garners high interest due to its implications for understanding obesity and metabolic health.

EngagementModerate engagement

Posters engage with the content by referencing mechanisms like thermogenesis and signaling pathways, indicating moderate discussion depth.

ImpactModerate impact

There's recognition that the research could influence future studies or treatment approaches, though it is not portrayed as immediately groundbreaking.

Abstract in brief

Recent findings show that mutations in the RSPO1 gene are linked to fat distribution and susceptibility to human obesity, with specific mutations found in some obese patients.
RSPO1 is primarily expressed in visceral fat and its overexpression can lead to obesity in mice by reducing thermogenesis, particularly under a high-fat diet.
The study highlights that excessive RSPO1 activates certain signaling pathways that inhibit fat burning in cells, suggesting that both the mutations and increased levels of RSPO1 contribute to obesity.

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RSPO1 Mutation Suppresses Beige Fat Thermogenesis and Promotes Obesity

This video discusses how human RSPO1 mutations repress beige adipocyte thermogenesis and contribute to diet-induced obesity, highlighting the gene's role in fat distribution and metabolic regulation.

STEM RTCL TV · Jul 21, 2023 54 views

Antonio Vidal-Puig

@VidalPuig · X

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet‐Induced... - https://t.co/vrJpr3OboC #ScholarAlerts

Feb 11, 2023 · 2 likes · 1,928 followers View post →

Adipose Papers

@adipose_papers · X

Human RSPO1 Mutation Represses Beige Adipocyte Thermogenesis and Contributes to Diet-Induced Adiposity https://t.co/quGbgXCPMm https://t.co/P5Z4kuBhdo

Feb 9, 2023 · 2,444 followers View post →