PubHawk
CPT Pharmacometrics Syst Pharmacol April 2023 PMID 36762714

N,N-dimethyltryptamine affects electroencephalography response in a concentration-dependent manner-A pharmacokinetic/pharmacodynamic analysis.

Emma Eckernäs, Christopher Timmermann, Robin Carhart-Harris, Daniel Röshammar, Michael Ashton

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Mentions

19
Peak: 16 in Feb 2023
across 3 sources since Feb 2023

Extended reach

85,198
potential audience

Total likes

73

Video views

23

Mentions per month

Feb 2023 – Jul 2023

Where it's discussed

  • X / Twitter16 posts
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions reflect a genuine interest and respect for the scientific work, with examples like 'dialling up the precision on DMT modelling' and references to detailed analyses indicating active engagement with the research's methodology and implications. The tone combines scientific curiosity with enthusiasm for future developments, which supports the overall positive and impactful perception of the publication.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some expressing enthusiasm about the precise modeling and potential applications.

InterestModerate interest

Participants show moderate curiosity, referencing the technical aspects of EEG responses and pharmacokinetic modeling generally related to DMT effects.

EngagementModerate engagement

The comments go beyond simple mentions, discussing the scientific methods, such as pharmacokinetic/pharmacodynamic analyses, indicating thoughtful engagement.

ImpactModerate impact

The discussions suggest that the research could influence future studies and clinical understanding of DMT, highlighted by phrases like 'dialing up the precision' and 'big info bombs.'

Abstract in brief

  • This study investigates how DMT, a psychedelic substance, affects brain activity measured by EEG, showing that its effects depend on the concentration in the blood and include suppression of alpha and beta brain wave powers as well as increased brain signal complexity.
  • Using pharmacokinetic/pharmacodynamic models, the research quantified the relationship between DMT plasma levels and EEG effects, finding specific concentrations (EC values) needed to achieve half-maximal responses, with alpha power being the most consistent response across subjects.
  • The findings highlight significant individual differences in response, especially for beta power and brain complexity, which could help inform optimal dosing and biomarker selection for DMT in future clinical and research applications.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Robin Carhart-Harris
@RCarhartHarris · X

Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic… https://t.co/SyeuhXMNnI

Feb 10, 2023 · 65 likes · 8 shares · 64,938 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analysis https://t.co/y7eP72hiif

Feb 10, 2023 · 6 likes · 3 shares · 4,013 followers View post →
THERADELICS
@theradelics · X

N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analysis https://t.co/btUSExzWP0 https://t.co/wZ8tBtJA1h

Feb 10, 2023 · 1 like · 1 share · 3,390 followers View post →
Dino Dvorak
@DinoDvorak · X

@RCarhartHarris PDF here: https://t.co/4bJJxPlu5e

Feb 10, 2023 · 1 like · 179 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @APRAresearch: N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analy…

Feb 10, 2023 · 3 shares · 4,084 followers View post →
Parker Singleton
@singletonion · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 10, 2023 · 8 shares · 1,926 followers View post →

All mentions

Seretoninen
@JTFS84 · X

RT @APRAresearch: N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analy…

Feb 13, 2023 · 3 shares · 996 followers View post →
TripsForTheSoul
@Tripsforthesoul · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 11, 2023 · 8 shares · 827 followers View post →
Raytheon
@raytheon306 · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 11, 2023 · 8 shares · 405 followers View post →
Robert
@CannaCriminal79 · X

RT @theradelics: N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analys…

Feb 11, 2023 · 1 share · 480 followers View post →
THERADELICS
@theradelics · X

N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analysis https://t.co/btUSExzWP0 https://t.co/wZ8tBtJA1h

Feb 10, 2023 · 1 like · 1 share · 3,390 followers View post →
Edgardo Mendoza
@Egardiando · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 10, 2023 · 8 shares · 299 followers View post →
Dino Dvorak
@DinoDvorak · X

@RCarhartHarris PDF here: https://t.co/4bJJxPlu5e

Feb 10, 2023 · 1 like · 179 followers View post →
REMAP Therapeutics
@REMAPTherapy · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 10, 2023 · 8 shares · 1,290 followers View post →
Robert
@CannaCriminal79 · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 10, 2023 · 8 shares · 480 followers View post →
Burritos Nostradamus
@BurritosNostra · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 10, 2023 · 8 shares · 505 followers View post →
Robert
@CannaCriminal79 · X

RT @APRAresearch: N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analy…

Feb 10, 2023 · 3 shares · 480 followers View post →
Parker Singleton
@singletonion · X

RT @RCarhartHarris: Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptam…

Feb 10, 2023 · 8 shares · 1,926 followers View post →
Robin Carhart-Harris
@RCarhartHarris · X

Dialling up the precision on DMT modelling. Big up the Swedes! More info bombs soon, just you wait! N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic… https://t.co/SyeuhXMNnI

Feb 10, 2023 · 65 likes · 8 shares · 64,938 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @APRAresearch: N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analy…

Feb 10, 2023 · 3 shares · 4,084 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analysis https://t.co/y7eP72hiif

Feb 10, 2023 · 6 likes · 3 shares · 4,013 followers View post →
ALIUS - @aliusresearch.bsky.social
@aliusresearch · X

N,N-dimethyltryptamine affects EEG response in a concentration dependent manner - a pharmacokinetic/pharmacodynamic analysis https://t.co/sqCOQ2F7y4

Feb 10, 2023 · 728 followers View post →