PubHawk
Nat Commun February 2023 PMID 36788246

Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies.

Delphine Planas, Timothée Bruel, Isabelle Staropoli, Florence Guivel-Benhassine, Françoise Porrot, Piet Maes, Ludivine Grzelak, Matthieu Prot, Said Mougari, Cyril Planchais, Julien Puech, Madelina Saliba, Riwan Sahraoui, Florent Fémy, Nathalie Morel

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Mentions

33
Peak: 24 in Nov 2022
across 4 sources since Nov 2022

Extended reach

330,785
potential audience

Total likes

40

Video views

72

Mentions per month

Nov 2022 – May 2023

Where it's discussed

  • X / Twitter27 posts
  • YouTube2 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

Overall, discussions demonstrate high agreement and interest, with posts describing the findings as warning signs for vaccine efficacy and treatment failures, using terms like 'concerning' and 'critical' to underscore the potential public health implications. The tone reflects a sense of urgency and focus on the importance of ongoing research and adaptation of medical strategies.

AgreementStrong agreement

Most discussions acknowledge the significance of the study, emphasizing the immune evasion capabilities of these subvariants.

InterestHigh interest

Participants display high interest, frequently referencing the mutations and the implications for treatment effectiveness.

EngagementModerate engagement

Many posts delve into technical details, suggesting a moderate level of engagement, with some sharing links and specific antibody efficacy data.

ImpactHigh impact

The discussions highlight considerable concern over the potential impact on vaccine and treatment strategies, indicating perceived high impact.

Abstract in brief

  • The convergent evolution of SARS-CoV-2 Omicron lineages has resulted in new subvariants like BA.2.75.2, BA.4.6, and BQ.1.1, with BQ.1.1 becoming dominant globally by December 2022.
  • These subvariants exhibit mutations in the spike protein that enhance their transmissibility and ability to evade immune responses.
  • Research indicates that many monoclonal antibodies (mAbs), including Ronapreve and Evusheld, show reduced effectiveness against these subvariants, with neutralizing antibody levels remaining low in fully vaccinated individuals, raising concerns about current treatment options in vaccinated populations.
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Top posts

Most liked on X and Bluesky
Emmanuel
@ejustin46 · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies @dfocosi @MoritzGerstung @shay_fleishon @PeacockFlu @RajlabN @JosetteSchoenma @C_A_Gustave @LongDesertTrain @siamosolocani https://t.co/jdn9XT7kw3

Nov 17, 2022 · 15 likes · 3 shares · 17,322 followers View post →
bioRxiv
@biorxivpreprint · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/k3CHU39TZA #bioRxiv

Nov 17, 2022 · 9 likes · 136,867 followers View post →
Roland Baker
@RolandBakerIII · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/JWKDfQXLc4

Nov 19, 2022 · 5 likes · 2 shares · 8,189 followers View post →
hirokazu kuroda@感染症内科医
@hrkz1985 · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies | bioRxiv https://t.co/tKLXsgYHdM

Nov 19, 2022 · 4 likes · 7,006 followers View post →
Joe Scholar
@JScholar · X

@IritBerman וחדשות עוד יותר טובות לאלו עם מערכת חיסונית מוחלשת המתחסנים עם החיסון הביוולנטי, שכן תתי הווריאנטים החדשים מתחמקים מהחיסון הפסיבי עם הנוגדנים המונוקלונלים הקיימים. Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/2mXA2MXvkV

Nov 18, 2022 · 4 likes · 1,183 followers View post →
bioRxiv Microbiology
@biorxiv_micrbio · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/5HV0XWN0oM #biorxiv_micrbio

Nov 17, 2022 · 3 likes · 1 share · 20,813 followers View post →

All mentions

DrRPalmquist
@DrPalmquist · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies - PMC https://t.co/U1acuWzOJk

Feb 18, 2023 · 3,160 followers View post →
the paper link
@the_paper_link · X

Trend new: Planas D, ..., Schwartz O (Nat Commun) __Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies__ https://t.co/FF1rZezRp4

Feb 16, 2023 · 138 followers View post →
micropapers
@micro_papers · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to neutralizing antibodies https://t.co/0gAncdqmCR

Feb 15, 2023 · 333 followers View post →
ALPINA
@ALPINA1965 · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/lPtYHTO3mU

Nov 23, 2022 · 95 followers View post →
Medical Science and Technology #earlytreatments
@MedicalScitech · X

Delphine Planas, Timothee Bruel, Isabelle Staropoli, et al. and Olivier Schwartz. Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies. bioRxiv 2022.11.17.516888; doi: https://t.co/4X5U7tdeJi https://t.co/FsTBh7wS5Z

Nov 21, 2022 · 632 followers View post →
Outbreak Science
@outbreaksci · X

New preprint: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/REbftk9M1K #COVID19

Nov 21, 2022 · 1,377 followers View post →
Steven Mathern
@StevenMathern · X

RT @RolandBakerIII: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/JWKDfQXLc4

Nov 19, 2022 · 2 shares · 457 followers View post →
marypg keating aka Mary-the-Cat
@marypgkeating · X

RT @RolandBakerIII: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/JWKDfQXLc4

Nov 19, 2022 · 2 shares · 3,169 followers View post →
Roland Baker
@RolandBakerIII · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/JWKDfQXLc4

Nov 19, 2022 · 5 likes · 2 shares · 8,189 followers View post →
Apolinar Picado Jr.
@ilsvezio · X

RT @ejustin46: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies @dfocosi @MoritzGerstung @shay_fle…

Nov 19, 2022 · 3 shares · 67 followers View post →
papers.bar
@papers_bar · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/5EeM57th71 ...

Nov 19, 2022 · 1,198 followers View post →
papers.bar
@papers_bar · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/5EeM57tOWz ...

Nov 19, 2022 · 1,198 followers View post →
hirokazu kuroda@感染症内科医
@hrkz1985 · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies | bioRxiv https://t.co/tKLXsgYHdM

Nov 19, 2022 · 4 likes · 7,006 followers View post →
cuttingedge (雑務家)
@cuttingedgevvv · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/QQlVEo18Lj

Nov 18, 2022 · 615 followers View post →
Federico Gueli
@siamosolocani · X

RT @ejustin46: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies @dfocosi @MoritzGerstung @shay_fle…

Nov 18, 2022 · 3 shares · 5,364 followers View post →
Javeria
@drJaveriaAhmad · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/2fRkKLd0KB

Nov 18, 2022 · 39 followers View post →
Michael Coston
@Fla_Medic · X

AFD Blog `Preprint: Resistance of #Omicron Subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to Neutralizing Antibodies' https://t.co/g6xw8eYl4Z

Nov 18, 2022 · 5,239 followers View post →
Prof. Dr. Sanjeev Bagai
@BagaiDr · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6, BQ.1.1 to nAbs: (Casirivimab & Imdevimab) & (Cilgavimab & Tixagevimab) lost any antiviral efficacy against BA.2.75.2, BQ.1.1, (Sotrovimab) remained weakly active. BQ.1.1 & resistant to Bebtelovimab. https://t.co/ARoSFrCAWs

Nov 18, 2022 · 34,762 followers View post →
Professor Erwin Loh
@erwinloh · X

Resistance of #Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing #antibodies - #Ronapreve (#Casirivimab and #Imdevimab) and #Evusheld (#Cilgavimab and #Tixagevimab) lost any #antiviral efficacy against BA.2.75.2 and BQ.1.1, whereas #Xevudy…https://t.co/4CB9DlclmH

Nov 18, 2022 · 9,556 followers View post →
Joe Scholar
@JScholar · X

@IritBerman וחדשות עוד יותר טובות לאלו עם מערכת חיסונית מוחלשת המתחסנים עם החיסון הביוולנטי, שכן תתי הווריאנטים החדשים מתחמקים מהחיסון הפסיבי עם הנוגדנים המונוקלונלים הקיימים. Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/2mXA2MXvkV

Nov 18, 2022 · 4 likes · 1,183 followers View post →
Emmanuel
@ejustin46 · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies @dfocosi @MoritzGerstung @shay_fleishon @PeacockFlu @RajlabN @JosetteSchoenma @C_A_Gustave @LongDesertTrain @siamosolocani https://t.co/jdn9XT7kw3

Nov 17, 2022 · 15 likes · 3 shares · 17,322 followers View post →
Kasia Hein-Peters, M.D.
@Kasia_HP · X

RT @GuzmanQCarlos: Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies | bioRxiv https://t.co/6QnUlRl…

Nov 17, 2022 · 1 share · 8,559 followers View post →
Carlos Guzman Quilo
@GuzmanQCarlos · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies | bioRxiv https://t.co/6QnUlRlykJ

Nov 17, 2022 · 1 share · 647 followers View post →
PromisingPreprints
@PromPreprint · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/RXL8SRyArN

Nov 17, 2022 · 3,312 followers View post →
MI6 ROGUE
@mi6rogue · X

Preliminary report; Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies: Convergent evolution of SARS-CoV-2 Omicron BA.2, BA.4 and BA.5 lineages has led to the emergence of several new subvariants,… Read more ↓ https://t.co/vhYlJWmpeZ

Nov 17, 2022 · 59,380 followers View post →
bioRxiv Microbiology
@biorxiv_micrbio · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/5HV0XWN0oM #biorxiv_micrbio

Nov 17, 2022 · 3 likes · 1 share · 20,813 followers View post →
bioRxiv
@biorxivpreprint · X

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies https://t.co/k3CHU39TZA #bioRxiv

Nov 17, 2022 · 9 likes · 136,867 followers View post →