Dermatol Ther (Heidelb) March 2023 PMID 36790724

A Review on the Safety of Using JAK Inhibitors in Dermatology: Clinical and Laboratory Monitoring.

Christeen Samuel, Hannah Cornman, Anusha Kambala, Shawn G Kwatra

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Mentions

10
Peak: 5 in Mar 2023
across 3 sources since Mar 2023

Extended reach

96,987
potential audience

Total likes

40

Video views

114

Mentions per month

Mar 2023 – Feb 2024

Where it's discussed

  • X / Twitter7 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions demonstrate a balanced tone, with posts like @drshawnkwatra expressing enthusiasm about research contributions, and others emphasizing the importance of careful risk assessment in practice. The tone and context communicate a meaningful engagement with the article’s implications for dermatological treatment, emphasizing the need for awareness and diligent monitoring.

AgreementModerate agreement

Most discussions recognize the importance and emerging role of JAK inhibitors in dermatology, reflecting general agreement with the article’s focus on safety and monitoring.

InterestModerate interest

Posts show moderate interest by discussing practical implications and new developments, indicating curiosity about how to implement findings.

EngagementModerate engagement

Participants reference specific research areas, such as risk stratification and monitoring protocols, suggesting a participative discussion that delves into clinical applications.

ImpactModerate impact

The discussions highlight the significance of the safety review for current and future clinical practice, emphasizing its influence on patient management strategies.

Abstract in brief

  • JAK inhibitors are effective treatments for various skin conditions but have safety concerns, leading the FDA to issue a black box warning based on studies in rheumatoid arthritis patients.
  • The safety profile of approved JAK inhibitors like abrocitinib, upadacitinib, baricitinib, deucravacitinib, and topical ruxolitinib show relatively low rates of serious adverse events such as blood clots, infections, and skin cancers, mostly occurring in patients with preexisting risk factors.
  • Clinicians should conduct careful initial screening and regular laboratory monitoring, considering patients' individual risk factors to minimize the potential adverse effects associated with JAK inhibitor therapy in dermatology.

Top posts

Most liked on X and Bluesky
Dr. Shawn Kwatra
@drshawnkwatra · X

Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,22). But there’s a lot to think about at the bedside with pts. Here’s our approach to risk stratification & lab monitoring https://t.co/KCw0mRml6R #dermtwitter https://t.co/mCPxqvPOWg

Mar 9, 2023 · 33 likes · 6 shares · 1,375 followers View post →
Top Biomedical Science
@imedverse · X

A Review on the Safety of Using JAK Inhibitors in #Dermatology: Clinical and Laboratory Monitoring https://t.co/c9GIjY76dq https://t.co/YyzfbEFKCF

Feb 24, 2024 · 6 likes · 1 share · 90,389 followers View post →
Jennifer Fugo, MS, LDN, CNS
@JenniferFugo · X

So glad that @drshawnkwatra is involved with research like this! Helping to provide guidance on JAK inhibitors for #atopicdermatitis #psoriasis #hidradenitissupporativa + more https://t.co/tn6e6K4A3E

Mar 9, 2023 · 1 like · 201 followers View post →
Sara Shalin
@MightyDermPath · X

RT @drshawnkwatra: Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,2…

Mar 9, 2023 · 6 shares · 4,304 followers View post →
Kyle Williams, MD
@kwill223 · X

RT @drshawnkwatra: Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,2…

Mar 9, 2023 · 6 shares · 336 followers View post →
Jeanine Lee, MD
@lee_jeanin78521 · X

RT @imedverse: A Review on the Safety of Using JAK Inhibitors in #Dermatology: Clinical and Laboratory Monitoring https://t.co/c9GIjY76dq…

Feb 24, 2024 · 1 share · 150 followers View post →

All mentions

Jeanine Lee, MD
@lee_jeanin78521 · X

RT @imedverse: A Review on the Safety of Using JAK Inhibitors in #Dermatology: Clinical and Laboratory Monitoring https://t.co/c9GIjY76dq…

Feb 24, 2024 · 1 share · 150 followers View post →
Top Biomedical Science
@imedverse · X

A Review on the Safety of Using JAK Inhibitors in #Dermatology: Clinical and Laboratory Monitoring https://t.co/c9GIjY76dq https://t.co/YyzfbEFKCF

Feb 24, 2024 · 6 likes · 1 share · 90,389 followers View post →
Sara Shalin
@MightyDermPath · X

RT @drshawnkwatra: Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,2…

Mar 9, 2023 · 6 shares · 4,304 followers View post →
Jennifer Fugo, MS, LDN, CNS
@JenniferFugo · X

So glad that @drshawnkwatra is involved with research like this! Helping to provide guidance on JAK inhibitors for #atopicdermatitis #psoriasis #hidradenitissupporativa + more https://t.co/tn6e6K4A3E

Mar 9, 2023 · 1 like · 201 followers View post →
Kyle Williams, MD
@kwill223 · X

RT @drshawnkwatra: Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,2…

Mar 9, 2023 · 6 shares · 336 followers View post →
Hannah Cornman
@HannahCornman · X

RT @drshawnkwatra: Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,2…

Mar 9, 2023 · 6 shares · 66 followers View post →
Dr. Shawn Kwatra
@drshawnkwatra · X

Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,22). But there’s a lot to think about at the bedside with pts. Here’s our approach to risk stratification & lab monitoring https://t.co/KCw0mRml6R #dermtwitter https://t.co/mCPxqvPOWg

Mar 9, 2023 · 33 likes · 6 shares · 1,375 followers View post →