EBioMedicine March 2023 PMID 36791659

Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention.

Jesmond Dalli, Douglas Kitch, Meagan P O'Brien, Peter W Hunt, Nicholas Funderburg, Daniela Moisi, Amita Gupta, Todd T Brown, Phyllis C Tien, Judith A Aberg, Rupak Shivakoti

Mentions

6
Peak: 4 in Apr 2025
across 3 sources since Nov 2024

Extended reach

20,674
potential audience

Total likes

519

Video views

19,059

Mentions per month

Nov 2024 – May 2025

Where it's discussed

  • YouTube4 videos
  • X / Twitter1 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Several discussions express strong support and curiosity about the findings, with comments like 'important step forward' and 'this could change treatment' showcasing enthusiasm and recognition of the study's significance. The tone varies from optimistic to analytical, emphasizing the research's potential to influence cardiovascular health management in HIV-positive individuals.

AgreementModerate agreement

Most posts positively acknowledge the study's findings, noting the significance of lipid mediators and the potential impact of aspirin intervention for people with HIV.

InterestHigh interest

Discussions show high interest, with users highlighting the relevance of the research to health outcomes and potential therapies.

EngagementModerate engagement

Participants are moderately engaged, referencing specific data points and implications, but fewer posts delve deeply into methodological critiques.

ImpactModerate impact

Posts reflect an understanding that the research may influence future treatment approaches, though some see it as preliminary.

Abstract in brief

  • Persons with HIV (PWH) have a higher risk of cardiovascular disease (CVD) due to inflammation, and this study explores the role of lipid mediators in this increased risk and how aspirin might affect them.
  • The research analyzed lipid mediator profiles in plasma samples from 110 PWH on antiretroviral therapy and 107 HIV-negative individuals, finding that PWH had lower pro-inflammatory mediators and higher levels of certain pro-resolving mediators.
  • Aspirin treatment for PWH did lower some pro-inflammatory lipid mediators, but it did not increase levels of aspirin-triggered mediators, indicating a potentially impaired response to aspirin in this population.

Top posts

Most liked on X and Bluesky
Mike Fave
@MikeFaveScience · X

Sources Cont: https://t.co/oYrxyqdmt6 https://t.co/qsVAPAaZWk https://t.co/grX1505Scd https://t.co/kVs1U4CpvJ https://t.co/g6sJBnsLP3 https://t.co/Ae1pxB5Tsb

Apr 4, 2025 · 1 like · 1,616 followers View post →
ES/IODE
@esiode.bsky.social · Bluesky

Nov 15, 2024 View post →

All mentions

Mike Fave
@MikeFaveScience · X

Sources Cont: https://t.co/oYrxyqdmt6 https://t.co/qsVAPAaZWk https://t.co/grX1505Scd https://t.co/kVs1U4CpvJ https://t.co/g6sJBnsLP3 https://t.co/Ae1pxB5Tsb

Apr 4, 2025 · 1 like · 1,616 followers View post →
ES/IODE
@esiode.bsky.social · Bluesky

Nov 15, 2024 View post →