Science February 2023 PMID 36795823

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors.

Maxemiliano V Vargas, Lee E Dunlap, Chunyang Dong, Samuel J Carter, Robert J Tombari, Shekib A Jami, Lindsay P Cameron, Seona D Patel, Joseph J Hennessey, Hannah N Saeger, John D McCorvy, John A Gray, Lin Tian, David E Olson

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Peak: 106 in Feb 2023
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AI synopsis

What people are saying

Several discussions highlight the complexities of how psychedelics affect the brain, such as one user citing the distinction between 'serotonin receptors outside the cell' versus '5-HT2A receptors inside the cell,' emphasizing a nuanced understanding of the study. The use of descriptive phrases like 'wow' and 'fascinating target' illustrate a tone that reflects both intrigue and a willingness to explore the subject further, contributing to the established interest in the research.

AgreementNeither agree nor disagree

There are mixed reactions, with some expressing skepticism toward the conclusions drawn from the study, while others acknowledge its contributions.

InterestHigh interest

Many discussions demonstrate a high level of curiosity regarding the implications and mechanisms presented in the research.

EngagementModerate engagement

Posts tend to engage on a surface level, with some deeper inquiries into receptors and neuroplasticity, but often drift toward speculative comments.

ImpactModerate impact

While the overall impact perceived is moderate, many users believe the findings could significantly influence future research and treatment methods.

Abstract in brief

  • Decreased dendritic spine density in the brain is linked to mental health issues, and psychedelics might help brain cells grow stronger.
  • Scientists found that a special receptor in the brain, called 5-HT2AR, is really important for how psychedelics change brain connections, but not all drugs that affect this receptor work the same way.
  • They discovered that the 5-HT2ARs inside brain cells might be the key to these changes, suggesting new ways to treat brain problems and hinting that serotonin might not be the usual signal for these receptors.

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Science Magazine
@ScienceMagazine · X

Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessible by serotonin, a Science study in mice found. The results reveal a possible psychedelic therapeutic mechanism. https://t.co/soGl7pvn8B #ScienceMagArchives https://t.co/WU8tVFnslN

Feb 24, 2024 · 390 likes · 86 shares · 4,516,316 followers View post →
h index enjoyer
@BigwetRealism · X

@whitefeelimgs Shrooms are literally mind-expanding. They induce neuroplasticity... https://t.co/DjkTL7xtd3

Mar 22, 2024 · 72 likes · 404 followers View post →
Neuroskeptic
@Neuro_Skeptic · X

Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow - serotonin receptors inside cells, I didn't know they existed. https://t.co/SHcx9mCtnr

Feb 17, 2023 · 60 likes · 11 shares · 232,891 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 16, 2023 · 45 likes · 9 shares · 4,013 followers View post →
CLaE
@leafs_s · X

Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 9, 2023 · 36 likes · 8 shares · 28,091 followers View post →
Beckley Foundation | Psychedelic Research
@BeckleyResearch · X

The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be enlightened. Psychedelics have been shown to promote neuroplasticity, as we explore the science, we paint the picture for reform. https://t.co/Tvd70bceaA

Apr 24, 2023 · 20 likes · 7 shares · 60,132 followers View post →

All mentions

TAD
@tadtadtad.bsky.social · Bluesky

There are a lot of leaps to come to this conclusion which the study explicitly states it is not coming to this simple conclusion www.science.org/doi/10.1126/...

Apr 5, 2025 · 1 like View post →
Orient Pilgrim
@OrientPilgrim · X

RT @trikomes:

Aug 19, 2024 · 114 shares · 2,622 followers View post →
DMT Quest
@dmt_quest · X

@SiliconPsychMD @spectatorindex It is the intracellular 5HT2A receptor that induces neuroplastic effects. Serotonin is hydrophilic not lipophilic so it is the unlikely catalyst. More likely bufotenin or DMT that acts upon the intracellular DMT as they are both lipophilic. https://t.co/xENgPnIWFt

Jun 20, 2024 · 2,440 followers View post →
waspdealer
@sonstwoher · X

RT @Helaway: @NeuroscienceNew Neuroplasticity, that is https://t.co/2kLKLr727o

May 25, 2024 · 1 share · 130 followers View post →
MO
@Helaway · X

@NeuroscienceNew Neuroplasticity, that is https://t.co/2kLKLr727o

May 25, 2024 · 1 like · 1 share · 385 followers View post →
дзушакей
@zushakei · X

https://t.co/KxcwB3wKyW i need love and love requires synaptic connection? or do i just want meaning for brain activities?

May 2, 2024 · 197 followers View post →
HellionVic
@VicHellion · X

RT @dmt_quest: Serotonin is non-lipophilic so cannot reach the intracellular 5-HT2A receptors responsible for neuroplastic effect? DMT is l…

Apr 24, 2024 · 2 shares · 387 followers View post →
DMT Quest
@dmt_quest · X

RT @dmt_quest: Serotonin is non-lipophilic so cannot reach the intracellular 5-HT2A receptors responsible for neuroplastic effect? DMT is l…

Apr 24, 2024 · 2 shares · 2,440 followers View post →
DMT Quest
@dmt_quest · X

@TrippAardema @alieninsect @RCarhartHarris @drdluke @Graham__Hancock The Olson lab at UC Davis would be the place to do so https://t.co/xENgPnIWFt

Apr 23, 2024 · 2,440 followers View post →
DMT Quest
@dmt_quest · X

Serotonin is non-lipophilic so cannot reach the intracellular 5-HT2A receptors responsible for neuroplastic effect? DMT is lipophilic so doesn't need to compete with serotonin intracellularly? A guess... https://t.co/xENgPnIWFt https://t.co/XeJyo8bTQs

Apr 23, 2024 · 10 likes · 2 shares · 2,440 followers View post →
Mitchigan
@MaaTchaKhun · X

RT @DrJamesCooke: Ever wondered why serotonin doesn’t produce the same effects as serotonergic psychedelics like LSD, psilocybin, and DMT?…

Apr 9, 2024 · 11 shares · 1,129 followers View post →
MO
@Helaway · X

@NeuroscienceNew https://t.co/2kLKLr727o

Apr 6, 2024 · 385 followers View post →
Jenny
@mommaleo · X

RT @Helaway: @mommaleo https://t.co/2kLKLr727o

Apr 2, 2024 · 1 share · 28,577 followers View post →
MO
@Helaway · X

@mommaleo https://t.co/2kLKLr727o

Apr 2, 2024 · 2 likes · 1 share · 385 followers View post →
h index enjoyer
@BigwetRealism · X

@whitefeelimgs Shrooms are literally mind-expanding. They induce neuroplasticity... https://t.co/DjkTL7xtd3

Mar 22, 2024 · 72 likes · 404 followers View post →
MEDNTD
@medntdj · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/EgDRw27psN The results reveal a possible psychedelic therapeutic mechanism. #ScienceMagArchives read more @ScienceMagazine https://t.co/RRxhf6movz

Feb 26, 2024 · 1 like · 911 followers View post →
blut des schweigens
@BlutDes · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 336 followers View post →
Psicólogo Celestino González-Fernández ψ
@Tecnoestres · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 2,903 followers View post →
LΞLΞL
@lelelx · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 3,832 followers View post →
timmit
@mahcmit · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 531 followers View post →
Michal Tal, PhD
@ImmunoFever · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 14,335 followers View post →
Akane
@Akanegg3 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 235 followers View post →
Farah Zaidi
@farahz09 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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尾呂内平太
@SKOZmyx3x36Mjxu · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 18 followers View post →
Carlos E. Goicochea
@Carlos_E_Goico · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 28 followers View post →
alfredo sampaio
@student_c_ · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 93 followers View post →
Rubén Moraga Mamani
@rmoragamamani · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 1,171 followers View post →
Sher Shah.
@SherSha43500558 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 89 followers View post →
Leonhard Schilbach
@leoschilbach · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 6,742 followers View post →
Carlos Iberico
@Cia1966 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 182 followers View post →
Aitor López
@CitizenSideral · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 155 followers View post →
Steppenwolf
@ghotar · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 390 followers View post →
giselle petzinger
@gpetzinger · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 738 followers View post →
ecto
@fatsquirrelnut · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 20 followers View post →
Johan Van Weyenbergh
@johanvawe · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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Mattia
@mattiamaroso · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 285 followers View post →
vladislov
@bellowthaw · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 102 followers View post →
hakan güner
@hakangunery · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 7,313 followers View post →
Comisión Investigación e Innovación Área V SESPA
@sespa5investiga · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 639 followers View post →
For Yet Better Science
@ForYetBetterSci · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 860 followers View post →
rajivk-substack
@RajivkSubstack · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 19 followers View post →
Katharina Pistor
@KatharinaPistor · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 1,470 followers View post →
JuanMatias-CreadorNarradorVisual
@JNarradorVisual · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 1,234 followers View post →
Vasseur JP
@jpvasseur · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 361 followers View post →
Wei Roc Song
@WeiRocSong · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 98 followers View post →
serpientedulce
@serpientedulce · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 195 followers View post →
John Smith⚛ (Explorer of Reality)
@doofgeek4011 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 4,088 followers View post →
Germán Sierra
@german_sierra · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 4,644 followers View post →
P123
@P1231032850 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 3,190 followers View post →
Herbert Elayda
@HerbertElayda · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 177 followers View post →
hmbreck
@hmbreck · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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Rob K Chalmers Jr/Hehàka Tò Hokśida
@obes88 · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Feb 24, 2024 · 86 shares · 2,846 followers View post →
Science Magazine
@ScienceMagazine · X

Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessible by serotonin, a Science study in mice found. The results reveal a possible psychedelic therapeutic mechanism. https://t.co/soGl7pvn8B #ScienceMagArchives https://t.co/WU8tVFnslN

Feb 24, 2024 · 390 likes · 86 shares · 4,516,316 followers View post →
Nick Jikomes
@trikomes · X

RT @trikomes:

Oct 10, 2023 · 114 shares · 10,534 followers View post →
Ian Freed
@braingutaxis · X

@MarkLRuffalo What about effects on neuroplasticity? https://t.co/o4TThJlPTl

Sep 30, 2023 · 52 followers View post →
Ace
@AceX1335 · X

@PLR_2024 @CheechMarin @tommychong @cheechandchong The medicinal application of some scheduled substances can not be ignored. Other studies and therapies are being done today. https://t.co/BA6KP7ANau

Jul 3, 2023 · 3 likes · 1,252 followers View post →
Escamez Lab
@ALEscamez · X

A new generation of antidepressant drugs? Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors | Science https://t.co/qGOo1l567H

Jun 27, 2023 · 8 likes · 1,365 followers View post →
Ace
@AceX1335 · X

@XRP_Productions @BlackberryXRP Psilocybin and neuroplasticity. https://t.co/BA6KP7ANau

Jun 17, 2023 · 1 like · 1,252 followers View post →
Jakub Schimmelpfennig
@psychedmt · X

@samuelxgarcia @tipado I am afraid the article is behind a paywall. https://t.co/RLKWtcimw2

Jun 10, 2023 · 2 likes · 365 followers View post →
Cube Flipper
@cube_flipper · X

@5matthewdub but the paper's paywalled so i haven't read it yet https://t.co/0cDSHQoWad

May 7, 2023 · 1 like · 3,717 followers View post →
Nick Dobos
@NickADobos · X

@hubermanlab Implications of 5ht2a receptor study & the notion of it getting stuck inside the receptor, causing long term downstream neuroplasticity Also, nootropics depot’s Cognance (concentrated ebelin bacopa??) as a possible non-psychedelic w/ similar benefit ???? https://t.co/4lAuwwpBf6

May 4, 2023 · 16 likes · 49,770 followers View post →
psyv
@psyv282j9d · X

@hubermanlab Does it exhibit the same action as ketamine: penetrating the neuron cell membrane and activating serotonin receptors inside the cell (stimulating dendrite growth)? Ref: https://t.co/10jA3nYwxf

May 4, 2023 · 1 like · 386 followers View post →
sanitybit
@sanitybit · X

RT @trikomes:

May 2, 2023 · 114 shares · 2,032 followers View post →
ShrumLane
@ShrumLane · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 26, 2023 · 7 shares · 2 followers View post →
Onaya
@onaya_io · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 25, 2023 · 7 shares · 462 followers View post →
Michel Blanc
@Blanc07Michel · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 25, 2023 · 7 shares · 1,663 followers View post →
Dr Fiona Hutton
@hutton_dr · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 25, 2023 · 7 shares · 1,258 followers View post →
Gerald Joseph, MSW, LCSW, ACM, PATP
@gerald_joseph90 · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 24, 2023 · 7 shares · 6,971 followers View post →
Psihedelnieks
@psihedelnieks · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 24, 2023 · 7 shares · 9 followers View post →
Ward Wyatt
@wardwyatt_ · X

RT @BeckleyResearch: The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be…

Apr 24, 2023 · 7 shares · 10,103 followers View post →
Beckley Foundation | Psychedelic Research
@BeckleyResearch · X

The underlying mechanisms which result in the effectiveness of psychedelics in treating mental illness, continue to be enlightened. Psychedelics have been shown to promote neuroplasticity, as we explore the science, we paint the picture for reform. https://t.co/Tvd70bceaA

Apr 24, 2023 · 20 likes · 7 shares · 60,132 followers View post →
Brian Scott Gross
@bsgpr · X

https://t.co/Y5WvavAq2J

Apr 20, 2023 · 1 like · 16,551 followers View post →
signal9.jp
@Signal9J · X

@nagainu_d 記事ではこの論文(『幻覚剤は細胞内5-HT2A受容体の活性化を通じて神経可塑性を促進する』)をリンクして「脳の新しい神経細胞の結合と組織の成長を刺激し、全身の炎症を抑える」云々という研究者の「直感」が書いてありますが、ちょっと飛躍しすぎのようなwww https://t.co/bOpZugQIYL

Apr 18, 2023 · 2 likes · 542 followers View post →
MO
@Helaway · X

@Doctor_I_am_The Thoughts on this phenomenon? https://t.co/2kLKLr727o

Apr 15, 2023 · 385 followers View post →
MO
@Helaway · X

@Kevin_McKernan @Jikkyleaks @JesslovesMJK @ClownBasket https://t.co/2kLKLr727o

Apr 15, 2023 · 385 followers View post →
MO
@Helaway · X

@Kevin_McKernan @Jikkyleaks @JesslovesMJK @ClownBasket https://t.co/2kLKLr727o

Apr 15, 2023 · 385 followers View post →
fortytooo
@fortytooo · X

RT @Matman28: @StuartHameroff Any chance microtubules might be related to the recently mentioned "intracellular receptor" for psychedelics?…

Apr 13, 2023 · 1 share · 5,793 followers View post →
Mathieu G
@Matman28 · X

@StuartHameroff Any chance microtubules might be related to the recently mentioned "intracellular receptor" for psychedelics? https://t.co/GJt9bS7atw

Apr 11, 2023 · 4 likes · 1 share · 483 followers View post →
Altamiro Bottino
@BottinoAltamiro · X

Receptor location matters for psychedelic drug effects https://t.co/rX5mqq0Bjf https://t.co/DuEXfJrl9Q https://t.co/HZupbgoc7Y https://t.co/QGuTEiS4nn

Mar 31, 2023 · 93 followers View post →
Translucence Biosystems
@BioTranslucence · X

...the plasticity-promoting effects of psychedelics. Find out more about the findings and their potential impact. https://t.co/ma4HdIrXSc #neuroscience #psychedelics #histology #brainplasticity #science #research #innovation

Mar 30, 2023 · 130 followers View post →
Michael Michelis
@_michelis_ · X

RT @agingdoc1: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/5OVYT4fAsd @Sci…

Mar 25, 2023 · 2 shares · 337 followers View post →
Nick Dobos
@NickADobos · X

@nopranablem Yes. Anti-depressant & hallucinatory effects are separate 5ht2a receptors outside the cell = hallucinations 5ht2a receptors inside the cell = downstream neuroplasticity and bdnf Due to ph, they get stuck inside, causing long term anti-depressant effect https://t.co/4lAuwwpBf6

Mar 23, 2023 · 5 likes · 49,770 followers View post →
Carolina Isaza
@IsazaCarolina1 · X

@DianaLuna07 Para que le ponga conocimiento a la opinión. https://t.co/reuE8QYgUy

Mar 22, 2023 · 4 likes · 250 followers View post →
Chemgeek@monomoy
@BethdietzLubba · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Mar 18, 2023 · 44 shares · 63 followers View post →
Suzanne Lea
@zydesu · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

Mar 18, 2023 · 44 shares · 2,880 followers View post →
Vern Lewis
@starvingscience · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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Victor Vergara
@vvergaram · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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W
@mushroom_magnum · X

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sciencenews
@Scieducation1 · X

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2bux15cents
@2bux15cents · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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@Margaret_Conde_ · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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Jon Rink
@JarnRink · X

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@A25627211gahueh · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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Aaro Dust
@aaron_dustin · X

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TiTi_12
@ThiTi_Bk · X

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@Rodrigo74080106 · X

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miki fern (covid 1, furious)
@miki_fern · X

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@Fuzzyfunker · X

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@100teafic · X

RT @ScienceMagazine: Some psychedelics achieve their effects by activating intracellular serotonin receptors that are not naturally accessi…

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Lucknow School Of Bio-Musicology
@bio_musicology · X

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BTristess Agent #5396
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CLaE
@leafs_s · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 12, 2023 · 8 shares · 28,091 followers View post →
BillOckham
@BillOccham0 · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 10, 2023 · 8 shares · 588 followers View post →
Dr. Mohita Shrivastava
@MohitaShrivast3 · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 10, 2023 · 8 shares · 209 followers View post →
Leonhard Schilbach
@leoschilbach · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 10, 2023 · 8 shares · 6,742 followers View post →
htw
@heniek_htw · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 10, 2023 · 8 shares · 11,265 followers View post →
Vahid Behzadan
@vbehzadan · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 9, 2023 · 8 shares · 1,127 followers View post →
CLaE
@leafs_s · X

Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/hsFn8yrJa5

Mar 9, 2023 · 36 likes · 8 shares · 28,091 followers View post →
Dániel Barabási
@bdanubius · X

March 7th: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors from @LinTianPhD @johnalangray @DEOlsonLab https://t.co/MWnRQZE8M3

Mar 8, 2023 · 1,977 followers View post →
Dániel Barabási
@bdanubius · X

#64: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors from @LinTianPhD @johnalangray @DEOlsonLab On structural and mechanistic reasons why psychedelics "open your mind"! https://t.co/Lvk3F0TeU6

Mar 8, 2023 · 1,977 followers View post →
Claudia Mar Ruiz
@Claudiaruiz · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors | Science https://t.co/3PunFplwX8

Mar 3, 2023 · 2 likes · 3,446 followers View post →
Michael Ostrolenk, MA, MFT
@mostrolenk · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/mBy9w0j8xY

Mar 3, 2023 · 1 like · 7,062 followers View post →
Researching the Brain
@Brain_Database · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors #brain https://t.co/zphxZmI5vp

Mar 2, 2023 · 1,038 followers View post →
Jaxon Christie
@ParabolSpirit · X

RT @PubTrend: Trending on PubMed: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. https://t…

Feb 28, 2023 · 3 shares · 591 followers View post →
Fábio Fonseca
@FbioFon84085623 · X

RT @PubTrend: Trending on PubMed: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. https://t…

Feb 27, 2023 · 3 shares · 576 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/nDr9qyIFWt

Feb 27, 2023 · 2,240 followers View post →
Manuel
@manusefir · X

RT @PubTrend: Trending on PubMed: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. https://t…

Feb 27, 2023 · 3 shares · 536 followers View post →
PubMed Trending
@PubTrend · X

Trending on PubMed: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. https://t.co/qqhI2O3CHN

Feb 27, 2023 · 3 likes · 3 shares · 5,154 followers View post →
DrRPalmquist
@DrPalmquist · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors - PubMed https://t.co/kFWy7SaC9U

Feb 27, 2023 · 1 like · 3,160 followers View post →
Jeff Robinson, CEO and Chairman of $MRES and $RLAB
@contrariansmind · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/P632u0JKCg @m2bio $MRES

Feb 27, 2023 · 1 like · 56,282 followers View post →
Lifeboat Foundation
@LifeboatHQ · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/9cv8wi0std

Feb 27, 2023 · 31,608 followers View post →
KidMelo_
@KidMelo_ · X

RT @trikomes:

Feb 26, 2023 · 114 shares · 634 followers View post →
Rich Hartman
@HartmanNeuroLab · X

Fascinating target for neuroplasticity modulators https://t.co/FkuyesLEDr

Feb 25, 2023 · 122 followers View post →
wolodya
@wolodya · X

RT @trikomes:

Feb 24, 2023 · 114 shares · 1,074 followers View post →
seal_2020
@seal_2020 · X

RT @trikomes:

Feb 24, 2023 · 114 shares · 456 followers View post →
Niko Bellic
@ComprehendFred · X

RT @trikomes:

Feb 24, 2023 · 114 shares · 182 followers View post →
Irrepress (A
@4cAbel · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 2,872 followers View post →
Christian Jimenez
@christianj024 · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 176 followers View post →
Christopher Conceal
@Christo62429078 · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 547 followers View post →
The Human Builder
@macbrazina · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 1,007 followers View post →
ἀλήθεια
@Ad_Astra93 · X

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Feb 23, 2023 · 114 shares · 443 followers View post →
The Community Urban Shaman
@community_urban · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 1,014 followers View post →
smoothee
@getsmoothee · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 53,747 followers View post →
Álvaro Fernández-Montero
@AlvaroFMontero · X

Really interesting read! Highly recommended Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/cVxviqnyOQ

Feb 23, 2023 · 1 like · 67 followers View post →
Salahudeen
@ThinkivistBlog · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 377 followers View post →
littlespottydog
@littlespottydog · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 1,811 followers View post →
Σόνκια ⭐
@Damien_notic · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 1,028 followers View post →
Lozza
@Laurenlondoner · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 2,870 followers View post →
The Canaanite
@mysticaltech · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 7,742 followers View post →
When Worlds Collide
@Uzumaki777Andre · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 21 followers View post →
Rue
@Ruandav_ · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 969 followers View post →
ashley
@ash_tollner · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 160 followers View post →
sweetleaf
@imsweetleaf · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 2,218 followers View post →
y0Loui / ℱ
@RedPillSoufle · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 1,064 followers View post →
nello
@bltyoga · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 6,027 followers View post →
Natasha L Mason / nlmason.bsky.social
@NL_Mason · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 2,130 followers View post →
Catherine Schuster-Bruce
@drcatherinesb · X

RT @trikomes:

Feb 23, 2023 · 114 shares · 1,150 followers View post →
Kama Atretkhany
@kama_atretkhany · X

RT @trikomes:

Feb 22, 2023 · 114 shares · 129 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/5OVYT4fAsd @Sci…

Feb 22, 2023 · 2 shares · 134 followers View post →
Mar Estarellas
@mar_estarellas · X

RT @trikomes:

Feb 22, 2023 · 114 shares · 379 followers View post →
Panos Bozelos
@BozelosP · X

RT @trikomes:

Feb 22, 2023 · 114 shares · 884 followers View post →
Sommerfieber Regen
@roland_regen · X

RT @trikomes:

Feb 22, 2023 · 114 shares · 36 followers View post →
Daniel Bocic Martinez
@Dan4CA31 · X

RT @trikomes:

Feb 21, 2023 · 114 shares · 4,775 followers View post →
Psy-brarian
@psybrarian · X

RT @trikomes:

Feb 21, 2023 · 114 shares · 68 followers View post →
Creative Bioarray
@CreaBioarray · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/WwNtFTJ9rb Increased global integration in the brain after psilocybin therapy for depression https://t.co/HpBXpxlqPh https://t.co/IGmIsk3tWb

Feb 21, 2023 · 1 like · 514 followers View post →
NirvanaEnElSamsara
@EnSamsara · X

“Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics” https://t.co/cnBjceHT95

Feb 21, 2023 · 588 followers View post →
Jacob
@parsi_val · X

the cite in question: https://t.co/DECfp3abxm

Feb 20, 2023 · 1 like · 11 followers View post →
Luca Iemi - neuroscience
@iemil_neuro · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 20, 2023 · 11 shares · 362 followers View post →
Destiny Carbello
@DestinyCarbello · X

RT @trikomes:

Feb 19, 2023 · 114 shares · 59 followers View post →
Hungerism
@lowhangingpoop · X

RT @trikomes:

Feb 19, 2023 · 114 shares · 53 followers View post →
Gavin Bell
@Gavin_R_Bell · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 19, 2023 · 9 shares · 17 followers View post →
Jochen Metzger
@JochenMetzger1 · X

RT @trikomes:

Feb 19, 2023 · 114 shares · 48 followers View post →
elastic steps
@elasticsteps · X

RT @drmikehart: A new paper suggests that psychedelics promote neuroplasticity (rewiring of the brain) through the 5-HT2A receptor. http…

Feb 19, 2023 · 1 share · 1,779 followers View post →
Jennifer Them
@JenniferThem · X

RT @trikomes:

Feb 19, 2023 · 114 shares · 55 followers View post →
Renzo Lanfranco
@Renzo_Lanfranco · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/4a6V7TiQsm

Feb 19, 2023 · 5 likes · 883 followers View post →
Dr Imran Sheikh
@DrImranSheikh · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/EmTp91VXK1 https://t.co/bLNoCqciH0

Feb 19, 2023 · 1 like · 24,190 followers View post →
Wan-Chen Lin
@WanChenLin2 · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 42 followers View post →
Santiago Guerrero
@sxguerrero · X

RT @KarimMajzoub: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/mwk7S1IR7z

Feb 18, 2023 · 1 share · 2,073 followers View post →
Artlippo
@Artlippo1 · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/eS2B8R1ynj

Feb 18, 2023 · 11 shares · 80 followers View post →
Urth Naturals
@UrthNaturals · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 40 followers View post →
Milad Soltanzadeh
@MiladSlt1 · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 121 followers View post →
Pájaro en el Alambre
@InaniLudibrio · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/eS2B8R1ynj

Feb 18, 2023 · 11 shares · 900 followers View post →
Dr. Sandra Dreisbach (she, her)
@sandradreisbach · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 477 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/eS2B8R1ynj

Feb 18, 2023 · 11 shares · 10,770 followers View post →
Dave Root
@NeuronRoot · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 2,707 followers View post →
Julia Schulte-Strathaus
@JuliaSchulte_S · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 581 followers View post →
Adam
@strivng4balance · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 561 followers View post →
Michael Carmody
@m_carmody · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 188 followers View post →
Sergio SánchezBustos
@llebllo · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 1,393 followers View post →
Johanna Luise Mayer
@JohannaLuiseM · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 102 followers View post →
Meredith Wade
@merebays · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 273 followers View post →
HealthNotes.jpg
@healthnotes_jpg · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 311 followers View post →
CLaE
@leafs_s · X

RT @leafs_s: Science Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/eS2B8R1ynj

Feb 18, 2023 · 11 shares · 28,091 followers View post →
Julie Holland, MD
@BellevueDoc · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 14,447 followers View post →
Karim Majzoub
@KarimMajzoub · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/mwk7S1IR7z

Feb 18, 2023 · 5 likes · 1 share · 1,859 followers View post →
nmixx
@nmixxch · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 243 followers View post →
Moritz Spangemacher
@MoesWisdom · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 141 followers View post →
Sashaina Fanibunda
@SashainaEF · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 664 followers View post →
Agingdoc
@agingdoc1 · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/5OVYT4fAsd @ScienceMagazine

Feb 18, 2023 · 14 likes · 2 shares · 41,340 followers View post →
Ariakas Enoreth
@Aenoreth · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/m5ezPp8LRA

Feb 18, 2023 · 1,010 followers View post →
Jeff W Welsh
@JeffWWelsh · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 18, 2023 · 11 shares · 105 followers View post →
Sebastiano A. Torrisi
@SebTorrisi · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 295 followers View post →
Rosaura Brisuela @roswitta.bsky.social
@Roswitamind · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 18, 2023 · 11 shares · 1,283 followers View post →
Kowshik Kukkemane
@kowshik_k2 · X

RT @trikomes:

Feb 18, 2023 · 114 shares · 186 followers View post →
helium hydride stan account
@organiccarbon · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 18, 2023 · 11 shares · 146 followers View post →
sato sei
@mttsubu · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 18, 2023 · 11 shares · 1,310 followers View post →
Director INMS
@DirectorInms · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/sj7WgM31ge

Feb 18, 2023 · 42 followers View post →
MisoPretty
@IGotGlitterOnMe · X

RT @trikomes:

Feb 17, 2023 · 114 shares · 1,643 followers View post →
Desi(c) Soul Unit
@icarusredux · X

RT @trikomes:

Feb 17, 2023 · 114 shares · 295 followers View post →
I’DEAL
@lafayetteideal · X

RT @trikomes:

Feb 17, 2023 · 114 shares · 33 followers View post →
Pedro Lobos Zambrano
@PLOBOSZQF · X

RT @trikomes:

Feb 17, 2023 · 114 shares · 168 followers View post →
Vidita Vaidya
@ViditaVaidya · X

RT @trikomes:

Feb 17, 2023 · 114 shares · 14,160 followers View post →
CheshireToad
@sneakeroggc · X

https://t.co/ilFaBlXt9C https://t.co/VIALW3xvqt

Feb 17, 2023 · 1 like · 262 followers View post →
Plausaible
@plausaible · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 17, 2023 · 11 shares · 140 followers View post →
Sandra Corvi
@CorviSandra · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 17, 2023 · 9 shares · 121 followers View post →
Sheila Gudgin
@SheilaGudgin · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 17, 2023 · 9 shares · 1,281 followers View post →
Mind Your Science!
@MindYourSci · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 17, 2023 · 11 shares · 134 followers View post →
Kenny Chiarelli Jr
@KennyChiarelli · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 17, 2023 · 9 shares · 434 followers View post →
Wayne State Neuroscience
@WayneStateNeuro · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 17, 2023 · 11 shares · 357 followers View post →
MedChemExpress
@MedChemExpress · X

#Science:#Psychedelics promote #neuroplasticity through the activation of intracellular #5-HT2A receptors. The study reasones that #LocationBias, might explain the difference in cellular signaling elicited by #serotonin and psychedelics. https://t.co/tLbF7YWoNP #MedChemExpress https://t.co/2XRkKMxMBF

Feb 17, 2023 · 1 like · 474 followers View post →
Manu Gupta
@guptam108 · X

RT @Neuro_Skeptic: Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow -…

Feb 17, 2023 · 11 shares · 1,090 followers View post →
Neuroskeptic
@Neuro_Skeptic · X

Intracellular 5-HT2A receptors mediate the plasticity-promoting properties of psychedelics https://t.co/GgCMaWN7KY Wow - serotonin receptors inside cells, I didn't know they existed. https://t.co/SHcx9mCtnr

Feb 17, 2023 · 60 likes · 11 shares · 232,891 followers View post →
kwitschas
@kwitschas · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 17, 2023 · 9 shares · 1,790 followers View post →
NirvanaEnElSamsara
@EnSamsara · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 17, 2023 · 9 shares · 588 followers View post →
Deirdre Walsh
@magicdmw · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 17, 2023 · 9 shares · 6,319 followers View post →
DMT Quest
@dmt_quest · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 16, 2023 · 9 shares · 2,440 followers View post →
Mind Escape Podcast
@MikeEscape · X

RT @APRAresearch: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 16, 2023 · 9 shares · 4,084 followers View post →
Amsterdam Psychedelic Research Association (APRA)
@APRAresearch · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/HbkAjELMl3

Feb 16, 2023 · 45 likes · 9 shares · 4,013 followers View post →
THERADELICS
@theradelics · X

Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors https://t.co/kKXfselDrW https://t.co/DrTqNEljl7

Feb 16, 2023 · 3,390 followers View post →