If you are interesting with bladder cancer check out our new finding ➡️ "FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer" https://t.co/Pz02JNfzUV
FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer.
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Nov 2021 – Jun 2023Where it's discussed
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What people are saying
The overall tone demonstrates strong interest and general agreement, with phrases like 'interesting' and 'drive the transcriptional networks' showing enthusiasm. The decisions to share and promote the article suggest a recognition of its relevance, though detailed critique is limited, leading to moderate scores for engagement and impact.
Most discussions acknowledge the significance of FLI1 and FRA1 in bladder cancer, showing general agreement with the findings.
The discussions indicate high interest, especially among readers involved in cancer research or related fields, as evidenced by enthusiastic phrases like 'interesting' and 'new finding' and the focus on potential therapeutic targets.
Posts actively share and promote the article, with some referencing the publication directly and encouraging others to read it, reflecting a moderate level of engagement.
While the posts highlight the importance of the research and its potential for treatment, they mostly serve as informational shares rather than deep discussions, indicating moderate perceived impact.
Abstract in brief
- The study identifies FRA1 and FLI1 as key transcription factors that regulate gene networks involved in muscle invasive bladder cancer (MIBC), impacting processes like cell migration and junction organization.
- Experimental knockdown of FRA1 and FLI1 in MIBC cells leads to reduced expression of EMT-related genes (such as MAP4K4 and FLOT1) and decreases the cells’ ability to invade muscle tissue.
- Using chromatin binding analysis, the research uncovers the molecular partnerships of FRA1 and FLI1, suggesting these factors could be targeted for developing new therapies for MIBC.
Top posts
Most liked on X and BlueskyIn @Nature: FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer. Click here to read the open-access article: https://t.co/u7eaFjAm5u #MIBC #bladdercancer
All mentions
Transcription Factors FLI1 and FRA1 in Muscle Invasive Bladder Cancer Development
This study identifies FLI1 and FRA1 as key regulators of gene networks involved in muscle invasive bladder cancer, impacting cell migration and junction organization. Knockdown reduces invasiveness, highlighting…
In @Nature: FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer. Click here to read the open-access article: https://t.co/u7eaFjAm5u #MIBC #bladdercancer
If you are interesting with bladder cancer check out our new finding ➡️ "FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer" https://t.co/Pz02JNfzUV
FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer https://t.co/ThuAaGspiq #bioRxiv