Commun Biol February 2023 PMID 36805539

FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer.

Perihan Yagmur Guneri-Sozeri, Gülden Özden-Yılmaz, Asli Kisim, Ece Cakiroglu, Aleyna Eray, Hamdiye Uzuner, Gökhan Karakülah, Devrim Pesen-Okvur, Serif Senturk, Serap Erkek-Ozhan

Mentions

4
Peak: 2 in Nov 2021
across 2 sources since Nov 2021

Extended reach

143,997
potential audience

Total likes

4

Video views

69

Mentions per month

Nov 2021 – Jun 2023

Where it's discussed

  • X / Twitter3 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone demonstrates strong interest and general agreement, with phrases like 'interesting' and 'drive the transcriptional networks' showing enthusiasm. The decisions to share and promote the article suggest a recognition of its relevance, though detailed critique is limited, leading to moderate scores for engagement and impact.

AgreementModerate agreement

Most discussions acknowledge the significance of FLI1 and FRA1 in bladder cancer, showing general agreement with the findings.

InterestHigh interest

The discussions indicate high interest, especially among readers involved in cancer research or related fields, as evidenced by enthusiastic phrases like 'interesting' and 'new finding' and the focus on potential therapeutic targets.

EngagementModerate engagement

Posts actively share and promote the article, with some referencing the publication directly and encouraging others to read it, reflecting a moderate level of engagement.

ImpactModerate impact

While the posts highlight the importance of the research and its potential for treatment, they mostly serve as informational shares rather than deep discussions, indicating moderate perceived impact.

Abstract in brief

  • The study identifies FRA1 and FLI1 as key transcription factors that regulate gene networks involved in muscle invasive bladder cancer (MIBC), impacting processes like cell migration and junction organization.
  • Experimental knockdown of FRA1 and FLI1 in MIBC cells leads to reduced expression of EMT-related genes (such as MAP4K4 and FLOT1) and decreases the cells’ ability to invade muscle tissue.
  • Using chromatin binding analysis, the research uncovers the molecular partnerships of FRA1 and FLI1, suggesting these factors could be targeted for developing new therapies for MIBC.

Top posts

Most liked on X and Bluesky
Gülden Özden Yılmaz
@guldenozdeny · X

If you are interesting with bladder cancer check out our new finding ➡️ "FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer" https://t.co/Pz02JNfzUV

Nov 24, 2021 · 3 likes · 1 share · 129 followers View post →
Bladder Cancer Advocacy Network
@BladderCancerUS · X

In @Nature: FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer. Click here to read the open-access article: https://t.co/u7eaFjAm5u #MIBC #bladdercancer

Feb 24, 2023 · 1 like · 6,412 followers View post →

All mentions

Bladder Cancer Advocacy Network
@BladderCancerUS · X

In @Nature: FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer. Click here to read the open-access article: https://t.co/u7eaFjAm5u #MIBC #bladdercancer

Feb 24, 2023 · 1 like · 6,412 followers View post →
Gülden Özden Yılmaz
@guldenozdeny · X

If you are interesting with bladder cancer check out our new finding ➡️ "FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer" https://t.co/Pz02JNfzUV

Nov 24, 2021 · 3 likes · 1 share · 129 followers View post →
bioRxiv
@biorxivpreprint · X

FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer https://t.co/ThuAaGspiq #bioRxiv

Nov 23, 2021 · 137,385 followers View post →