Nat Commun February 2023 PMID 36806170

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport.

Laura Bojarskaite, Alexandra Vallet, Daniel M Bjørnstad, Kristin M Gullestad Binder, Céline Cunen, Kjell Heuser, Miroslav Kuchta, Kent-Andre Mardal, Rune Enger

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Mentions

24
Peak: 4 in Mar 2023
across 4 sources since Feb 2023

Extended reach

86,132
potential audience

Total likes

33

Video views

17

Mentions per month

Feb 2023 – Jun 2023

Where it's discussed

  • X / Twitter11 posts
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  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions show strong interest and moderate engagement, with comments highlighting the importance of sleep-dependent vascular changes, exemplified by remarks on how vessel dynamics during sleep phases could enhance waste clearance in the brain. The tone indicates appreciation and recognition of the research's potential significance, due to word choices like 'fascinating' and phrases emphasizing the role of sleep in brain health.

AgreementModerate agreement

Most discussions acknowledge the significance of the research findings, indicating a general agreement with the scientific conclusions and potential implications.

InterestHigh interest

The discussions reflect high interest, with commenters emphasizing the importance of sleep in brain health and fluid dynamics, using phrases like 'fascinating' and 'important discovery.'

EngagementModerate engagement

Posts demonstrate moderate engagement by referencing specific aspects of the study, such as vascular changes during sleep phases, showing users are processing the information thoughtfully.

ImpactModerate impact

Participants suggest the research could influence future studies or clinical approaches, implying the findings may have a moderate to high impact on neuroscience and sleep research fields.

Abstract in brief

  • Perivascular spaces in the brain play a crucial role in facilitating fluid and solute transport for waste clearance during sleep, but the mechanisms influencing this flow are not fully understood.
  • In a study with sleeping mice, researchers observed distinct changes in blood vessel dynamics during different sleep phases: slow oscillations during NREM sleep, vasodilation in REM sleep, and vasoconstriction upon waking.
  • Biomechanical modeling suggests that these sleep-dependent changes in blood flow and vessel size enhance the movement of fluids in perivascular spaces, potentially improving waste removal to levels seen during heartbeats.

Top posts

Most liked on X and Bluesky
Hiromasa Funato
@HiromasaFunato · X

睡眠と覚醒では脳の動脈の径や周囲腔のサイズがダイナミックに変わる。でも静脈系では変化が見られない。 クリックすると小動脈(赤いところ)の太さがノンレム睡眠では変動し、レム睡眠で大きくなり、覚醒できゅっと縮まるのが見えます。 https://t.co/eH3cEKXWUP https://t.co/H4At3F0YeN

Mar 11, 2023 · 15 likes · 2 shares · 2,060 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport https://t.co/Kb5c0cVkqZ

Feb 21, 2023 · 9 likes · 1 share · 1,956 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Bojarskaite L, Vallet A, Bjørnstad DM, et al. Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport. Nat Commun. 2023;14(1):953. doi: 10.1038/s41467-023-36643-5 https://t.co/XaYEGTsscb

Apr 1, 2023 · 8 likes · 3 shares · 15,704 followers View post →
Agingdoc
@agingdoc1 · X

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport https://t.co/dD17hz57uY @NatureComms https://t.co/lwkAJDdxlO

Mar 31, 2023 · 1 like · 41,343 followers View post →
ケロ爺
@kero_jiji · X

RT @norionakatsuji: 元論文→ Bojarskaite L, Vallet A, Bjørnstad DM, et al. Sleep cycle-dependent vascular dynamics in male mice and the predict…

Apr 1, 2023 · 3 shares · 8,509 followers View post →
Sleep Research
@SleepResearch_ · X

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport https://t.co/lxIpsUcaXD

Feb 22, 2023 · 7,263 followers View post →

All mentions

あの日、ミッに呼ばれたかもしれない
@anohimihakuseki · X

RT @norionakatsuji: 元論文→ Bojarskaite L, Vallet A, Bjørnstad DM, et al. Sleep cycle-dependent vascular dynamics in male mice and the predict…

Apr 1, 2023 · 3 shares · 1,019 followers View post →
桶屋 猫之介
@diccogiale21 · X

RT @norionakatsuji: 元論文→ Bojarskaite L, Vallet A, Bjørnstad DM, et al. Sleep cycle-dependent vascular dynamics in male mice and the predict…

Apr 1, 2023 · 3 shares · 357 followers View post →
ケロ爺
@kero_jiji · X

RT @norionakatsuji: 元論文→ Bojarskaite L, Vallet A, Bjørnstad DM, et al. Sleep cycle-dependent vascular dynamics in male mice and the predict…

Apr 1, 2023 · 3 shares · 8,509 followers View post →
Norio Nakatsuji
@norionakatsuji · X

元論文→ Bojarskaite L, Vallet A, Bjørnstad DM, et al. Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport. Nat Commun. 2023;14(1):953. doi: 10.1038/s41467-023-36643-5 https://t.co/XaYEGTsscb

Apr 1, 2023 · 8 likes · 3 shares · 15,704 followers View post →
Agingdoc
@agingdoc1 · X

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport https://t.co/dD17hz57uY @NatureComms https://t.co/lwkAJDdxlO

Mar 31, 2023 · 1 like · 41,343 followers View post →
Tatsuhiko Fujimoto
@Tatsu_Fujimoto · X

RT @HiromasaFunato: 睡眠と覚醒では脳の動脈の径や周囲腔のサイズがダイナミックに変わる。でも静脈系では変化が見られない。 クリックすると小動脈(赤いところ)の太さがノンレム睡眠では変動し、レム睡眠で大きくなり、覚醒できゅっと縮まるのが見えます。 https:…

Mar 12, 2023 · 2 shares · 4,819 followers View post →
えばしゅう
@koburouze845 · X

RT @HiromasaFunato: 睡眠と覚醒では脳の動脈の径や周囲腔のサイズがダイナミックに変わる。でも静脈系では変化が見られない。 クリックすると小動脈(赤いところ)の太さがノンレム睡眠では変動し、レム睡眠で大きくなり、覚醒できゅっと縮まるのが見えます。 https:…

Mar 11, 2023 · 2 shares · 2,177 followers View post →
Hiromasa Funato
@HiromasaFunato · X

睡眠と覚醒では脳の動脈の径や周囲腔のサイズがダイナミックに変わる。でも静脈系では変化が見られない。 クリックすると小動脈(赤いところ)の太さがノンレム睡眠では変動し、レム睡眠で大きくなり、覚醒できゅっと縮まるのが見えます。 https://t.co/eH3cEKXWUP https://t.co/H4At3F0YeN

Mar 11, 2023 · 15 likes · 2 shares · 2,060 followers View post →
Sleep Research
@SleepResearch_ · X

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport https://t.co/lxIpsUcaXD

Feb 22, 2023 · 7,263 followers View post →
Vicente Medel
@medelero · X

RT @NeuroPaperBot: Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow…

Feb 21, 2023 · 1 share · 869 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Sleep cycle-dependent vascular dynamics in male mice and the predicted effects on perivascular cerebrospinal fluid flow and solute transport https://t.co/Kb5c0cVkqZ

Feb 21, 2023 · 9 likes · 1 share · 1,956 followers View post →