La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína citrulinada (ACPA) detectables, lo que implica la inflamación de la mucosa oral en la patogénesis de la AR. https://t.co/u90eeKYD8m https://t.co/M5M7B3uzyI
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.
Mentions
Extended reach
Total likes
Video views
Mentions per month
Feb 2023 – May 2025Where it's discussed
-
X / Twitter108 posts
-
News69 articles
-
Blogs9 articles
-
YouTube3 videos
-
Facebook2 posts
AI synopsis
What people are saying
Several posts highlight the article's implications by mentioning specific bacterial strains, such as Porphyromonas gingivalis, and their role in triggering inflammation in rheumatoid arthritis. For example, comments regarding the direct link between periodontal disease and rheumatoid arthritis underscore the perceived importance of the findings. The tone of fascination, reflected in phrases like 'wow' and 'interesting,' enhances the perceived significance of the study within the academic and medical communities.
The majority of discussions express a strong consensus regarding the article's findings and implications for rheumatoid arthritis.
Posts reflect high levels of curiosity and relevance, particularly in connecting oral health and autoimmune diseases.
Many posts highlight detailed insights and implications of the study, indicating a deep engagement with the topic.
Contributors perceive the publication as having significant potential ramifications for understanding and treating rheumatoid arthritis.
Abstract in brief
- Oral mucosal breaks in rheumatoid arthritis (RA) patients, particularly those with periodontal disease, lead to the release of citrullinated bacteria into the bloodstream, triggering immune responses.
- This response includes the activation of inflammatory monocyte subsets linked to flares in RA, as indicated by specific transcriptomic signatures found in both blood and inflamed joints.
- Further, the citrullinated bacteria stimulate the production of anticitrullinated protein antibodies (ACPAs) by B cells, which may enhance the immune response against both bacterial and human proteins.
Top posts
Most liked on X and BlueskyWow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis severity by allowing citrullinated oral bacteria into the bloodstream — bugs activate inflammatory monocytes causing disease flares https://t.co/Y35Py0O6CA https://t.co/cyQ5IvGI9r
Bacteria are then able to trigger an autoimmune response seen in rheumatoid arthritis. https://t.co/ZtPeeYZtIe
Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute to rheumatoid arthritis by triggering specific immune responses via @ScienceTM: https://t.co/aSdBs28EO5
An analysis of patients with #RheumatoidArthritis and #PeriodontalDisease shows they experience transient oral bacteremia that activate ACPA antibodies, hinting that breaches in oral mucosa may trigger inflammatory flares. @danaorange @StanfordRheum https://t.co/eo2SK9DXIv https://t.co/Vn5sSIO6Gp
All mentions
Dentes que previnem o reumatismo. @dicamedica
Impact of Intermittent Fasting on Oral Health and Disease
This video explores how intermittent fasting can affect periodontal disease and improve overall oral health. It discusses key connections between oral mucosal health, immune responses, and fasting, while referencing…
Oral Health and Disease: Understanding the Connection
See why oral health is key for disease prevention and longevity. Oral mucosal breaks in rheumatoid arthritis patients can trigger immune responses through the release of citrullinated bacteria, highlighting the…
https://t.co/fSOPOK6Dun
@UWRheum @KristiKuhn RA & microbiome: Dana Orange & Bill Robinson @StanfordRheum In the gingivitis realm… Bacterial proteins citrullinated and recognized by the immune system https://t.co/6zNIoxPkX9 #ACR23
@CovidCastaways Increasing evidence of chronic infections causing autoimmune diseases. See below about how a team showed that p.gingivalis bacteria cause some cases of rheumatoid arthritis. Some in this team also showed how Epstein Barr virus causes Multiple sclerosis https://t.co/vwcyYSh3ZD
@LoriShemek @DrGrahamLJ Also Rheumatoid arthritis (see paper below). We know that mast cells are crucial to osteoarthritis & people with this illness have bone marrow lesions. I believe pathogens play a key role in this disease as well. https://t.co/vwcyYSh3ZD
@chydorina @remissionbiome You're right. Bacteria infections as well. https://t.co/vwcyYShBPb
2)Peripheral tolerance (=generating Treg periphery) induced by Lymph node stromal cells was altered in RA. 3)Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in RA DOI: 10.1126/scitranslmed.abq8476 https://t.co/mq3qBR4Ml6
@DrGrahamLJ @mvankerkhove You're right. I saw this recently. The team found that mouth bacteria, especially Porphyromonas gingivalis, triggers an inflammatory cascade leading to rheumatoid arthritis. Authors include T Lanz & W Robinson who co-wrote a very important MS study. https://t.co/vwcyYSh3ZD
A small study, recently published in the journal Science Translational Medicine, offered convincing evidence for a direct link between periodontal disease and rheumatoid arthritis (RA). Read the study at https://t.co/nYCIX3LoLn. #ArthritisAwarenessMonth #OralHealth #Dentistry https://t.co/wYA7EUfQXO
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @ygjumi: Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis https://t…
RT @ygjumi: Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis https://t…
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis https://t.co/9pWNxKopX5
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
#Gumdisease may lie at the root of some #arthritis flareups @RockefellerUniv @sciencetm https://t.co/6rvVRZF42v https://t.co/QWOZrmS0HB
https://t.co/81UXbhgHtC "which (ii) activate inflammatory monocyte subsets that are observed in inflamed RA synovia and blood of RA patients with flares and (iii) activate ACPA B cells, thereby promoting affinity maturation and epitope spreading to citrullinated human antigens."
https://t.co/81UXbhgHtC "Together, these results suggest that (i) periodontal disease results in repeated breaches of the oral mucosa that release citrullinated oral bacteria into circulation,"
https://t.co/81UXbhgHtC "The oral bacteria observed transiently in blood were broadly citrullinated in the mouth, and their in situ citrullinated epitopes were targeted by extensively somatically hypermutated ACPAs encoded by RA blood plasmablasts."
https://t.co/81UXbhgHtC "patients with RA and periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of ISG15+HLADRhi and CD48highS100A2pos monocytes, recently identified in inflamed RA synovia and blood of those with RA flares."
https://t.co/81UXbhgHtC "Here, we performed paired analysis of human and bacterial transcriptomics in longitudinal blood samples from RA patients."
https://t.co/81UXbhgHtC "Periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anti-citrullinated protein antibodies (ACPAs), implicating oral mucosal inflammation in RA pathogenesis."
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis https://t.co/81UXbhgHtC
RT @GMFHx: Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute t…
RT @GMFHx: Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute t…
RT @GMFHx: Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute t…
RT @GMFHx: Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute t…
RT @GMFHx: Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute t…
RT @GMFHx: Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute t…
Is there a link between periodontal disease and rheumatoid arthritis? New findings suggest periodontal disease may contribute to rheumatoid arthritis by triggering specific immune responses via @ScienceTM: https://t.co/aSdBs28EO5
Study suggests causative pathway between gum disease and rheumatoid arthritis https://t.co/9DTlF0NpsT https://t.co/jgh632tvop https://t.co/Tedmtg4HlV
A new study shows that gum disease may contribute to rheumatoid arthritis For more information on the study: https://t.co/SiUNFQH9UK #gumdisease #teeth #dentalhealth #rheumatoidarthritis #arthritis #autoimmune #autoimmunedisease #RA #dentistry #dentist https://t.co/CnkQtf3iCN
ICYMI: A recent #NIAMSFunded study suggests periodontal disease may contribute to rheumatoid arthritis flares. Read the study abstract: https://t.co/qGwvTGPG5c
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
Sci Transl Med PG菌などによって菌体自体のシトルリン化が進んで、それが歯周病によって循環中に漏れる それに対する抗原特異的免疫反応が進むと同時に、繰り返されるシトルリン化細菌の暴露、エピトープスプレディング、ACPAが産生、RAへ https://t.co/75thnGnhQZ
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
البحث العلمي في أسبوع https://t.co/wQ16shE2jI #طبيبي #تطبيق_طبيبي #ابن_سينا_الطبي https://t.co/VBjfUALbXl https://t.co/GEplIb7rfG
RT @victornizet: Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis se…
RT @victornizet: Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis se…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
Very specific attention to the effect of #periodontal disease and #oralhealth - in #rheumatoidarthritis https://t.co/UMKmSXYUbU
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
RT @victornizet: Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis se…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
RT @gamonasterioo:
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @ScienceTM: An analysis of patients with #RheumatoidArthritis and #PeriodontalDisease shows they experience transient oral bacteremia th…
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
An analysis of patients with #RheumatoidArthritis and #PeriodontalDisease shows they experience transient oral bacteremia that activate ACPA antibodies, hinting that breaches in oral mucosa may trigger inflammatory flares. @danaorange @StanfordRheum https://t.co/eo2SK9DXIv https://t.co/Vn5sSIO6Gp
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
RT @gamonasterioo:
RT @victornizet: Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis se…
RT @victornizet: Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis se…
RT @IlindelatorreMD: La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína c…
RT @victornizet: Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis se…
Wow - new @ScienceTM @RCamilleBrewer @DanaOrange @Stanford @RockefellerUniv Gum disease linked to rheumatoid arthritis severity by allowing citrullinated oral bacteria into the bloodstream — bugs activate inflammatory monocytes causing disease flares https://t.co/Y35Py0O6CA https://t.co/cyQ5IvGI9r
La enfermedad periodontal es más común en personas con artritis reumatoide (AR) que tienen anticuerpos anti-proteína citrulinada (ACPA) detectables, lo que implica la inflamación de la mucosa oral en la patogénesis de la AR. https://t.co/u90eeKYD8m https://t.co/M5M7B3uzyI
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
Autoimmune diseases are so dang complicated as they silently damage our bodies. Grateful to scientists for helping to understand these intricate mechanisms & subsequent problems. Interesting
https://t.co/V1WzLGnu1k
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses... https://t.co/1bxU0lsJp5
RT @white_bite: Bacteria are then able to trigger an autoimmune response seen in rheumatoid arthritis. https://t.co/ZtPeeYZtIe
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
Mechanistic evidence supporting the link between #periodontaldisease and #rheumatoidarthritis (RA) #oralhealth #microbiome #microbiota https://t.co/9RiPnkZX5k https://t.co/rxbpJhz9Rh
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
RT @HatragyiSafarne: Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
RT @medical_xpress: Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https:…
Study suggests causative pathway between gum disease and #rheumatoidarthritis @sciencetm https://t.co/VBvG9npXhl https://t.co/JUL2B09cuG
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @white_bite: Bacteria are then able to trigger an autoimmune response seen in rheumatoid arthritis. https://t.co/ZtPeeYZtIe
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @white_bite: Bacteria are then able to trigger an autoimmune response seen in rheumatoid arthritis. https://t.co/ZtPeeYZtIe
Bacteria are then able to trigger an autoimmune response seen in rheumatoid arthritis. https://t.co/ZtPeeYZtIe
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
RT @danaorange: I’m pleased to share our new paper showing how “leaky gums” can contribute to disease activity in rheumatoid arthritis. #r…
Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis. - Brewer RC et al. - https://t.co/6d83Dh7o7a #microbiome
RT @westr: NB: Oral mucosal breaks trigger anti-#citrullinated bacterial and human protein antibody responses in #rheumatoidarthritis https…
NB: Oral mucosal breaks trigger anti-#citrullinated bacterial and human protein antibody responses in #rheumatoidarthritis https://t.co/95jlAjxdrO #ACPA+ #Rheum #RA #cittruline #periodonatal #SystemsBiology: Mouth #microbiome jurisdiction of systemic #joint disease.
RT @HSSProfEd: Newly published in @ScienceTM — Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody response…
Newly published in @ScienceTM — Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis #RheumTwitter @HSpecialSurgery https://t.co/mkYv5rFlGd